导师姓名： 高小玲 专业代码： 100700
性别： 女 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： **-776580
邮编： 200025 邮箱地址： shellygao1@sjtu.edu.cn

研究方向 (点击浏览详细信息)
脑靶向药物递送和神经退行性疾病新药研发
生物大分子药物递释技术
纳米药物载体的生物学效应及其机制研究

社会任职
中国药学会会员
上海市药学会药理学专业委员会委员
Acta Pharmaceutica Sinica B青年编委
中国药理学会会员
Bioconjugate Chemistry编委
美国药学会会员
国际控释协会会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 小胶质细胞介导的纳米递药系统脑内转运及其机制研究 国家自然科学基金委 2020-01~2023-12 55万元 课题负责人
** 卟啉脂蛋白纳米诊疗系统实现精准清除脑胶质瘤残余灶的研究 上海市科委 2019-04~2023-03 50万元 课题负责人
** 药剂学 国家自然科学基金（优秀青年科学基金） 2018-01~2020-12 130万元 课题负责人
2018 ****青年拔尖人才 中组部 2018-01~2020-12 170万元 课题负责人
15SG14 曙光计划 上海市教委 2016-01~2018-12 15万元 课题负责人
** 重组高密度脂蛋白纳米递药系统的脑内清除机制研究 国家自然科学基金 2016-01~2019-12 83.28万元 课题负责人
** 基于beta淀粉样蛋白清除的仿生纳米生物结构优化及其细胞生物学机制研究 上海市科委国际合作 2015-09~2018-09 30万元 课题负责人
** 具有Aβ寡聚体触发释药特性的仿生纳米载药系统构建及其针对阿尔茨海默病的分子靶向递药研究 国家自然科学基金 2014-01~2017-12 65万元 课题负责人
12nm** 基于脑内药物递送的重组高密度脂蛋白纳米药物传递系统的可控制备关键技术及其生物安全性评价 上海市科委纳米专项 2012-10~2015-06 30万元 课题负责人
12ZR** 超声联合微泡介导功能化纳米粒实现脑内病灶靶向递药研究 上海市科委自然科学基金 2012-07~2015-06 10万元 课题负责人
12ZZ107 基于老年性痴呆早期诊疗的仿生高密度脂蛋白纳米技术研究 上海市教委科研创新重点项目 2012-01~2014-12 16万元 课题负责人
10QA** 聚酯纳米载药系统的胞吞转运途径及其分子机制研究 上海市青年科技启明星计划项目 2010-04~2012-03 15万元 课题负责人
** 凝集素修饰纳米粒的胞吞转运途径及其Rab蛋白介导机制 国家自然基金项目 2009-01~2011-12 20万元 课题负责人
2009ZX09103-077 具有多靶点作用抗老年性痴呆候选药物XQ509的研究 国家“新药创制”科技重大专项 ~ 150万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Songlei Zhou,Yukun Huang,Yu Chen,Shanshan Liu,Minjun Xu,Tianze Jiang,Qingxiang Song,Gan Jiang,Xiao Gu,Xiaoling Gao* （通讯作者）,Jun Chen* Engineering ApoE3-incorporated biomimetic nanoparticle for efficient vaccine delivery to dendritic cells via macropinocytosis to enhance cancer immunotherapy Biomaterials 2020 235:119795
Chen YX, Wei CX1, Lyu YQ, Chen HZ, Jiang G*, Gao XL* （通讯作者） Biomimetic drug-delivery systems for the management of brain diseases Biomater Sci 2020 8(4):1073-1088
Jingxian Feng,Minjun Xu,Jiahao Wang,Songlei Zhou,Yipu Liu,Shanshan Liu,Yukun Huang,Yu Chen,Liang Chen,Qingxiang Song,Jingru Gong,Huiping Lu,Xiaoling Gao* （通讯作者）,Jun Chen* Sequential delivery of nanoformulated α-mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer Biomaterials 2020 241:119907
Xiao Gu, Qingxiang Song, Qian Zhang,Meng Huang,Mengna Zheng,Juan Chen,Dan Wei,Jun Chen,Xunbin Wei,Hongzhuan Chen*,Gang Zheng*,Xiaoling Gao* （通讯作者） Clearance of two organic nanoparticles from the brain via the paravascular pathway Journal of Controlled Release 2020 322:31-41
Yukun Huang,Yu Chen,Songlei Zhou,Liang Chen,Jiahao Wang,Yuanyuan Pei,Minjun Xu,Jingxian Feng,Tianze Jiang,Kaifan Liang,Shanshan Liu,Qingxiang Song,Gan Jiang,Xiao Gu,Qian Zhang,Xiaoling Gao* （通讯作者）,Jun Chen* Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors Nature Communications 2020 11(4):622
Lepei Chen, Qingxiang Song, Yaoxing Chen, Shuang Meng, Mengna Zheng, Jialin Huang, Qian Zhang, Jiyao Jiang, Junfeng Feng, Hongzhuan Chen, Gan Jiang*, Xiaoling Gao* （通讯作者） Tailored Reconstituted Lipoprotein for Site-Specific and Mitochondria-Targeted Cyclosporine A Delivery to Treat Traumatic Brain Injury ACS Nano 2020 doi: 10.1021/acsnano.9b09186
Gan Jiang, Huan Chen, Jialin Huang,Qingxiang Song,Yaoxing Chen,Xiao Gu,Zhenhuan Jiang,Yukun Huang,Yingying Lin,Junfeng Feng,Jiyao Jiang,Yinghui Bao,Gang Zheng,Jun Chen*,Hongzhuan Chen*,Xiaoling Gao*. （通讯作者） Tailored Lipoprotein‐Like miRNA Delivery Nanostructure Suppresses Glioma Stemness and Drug Resistance through Receptor‐Stimulated Macropinocytosis Advanced Science 2020 7(5):**
Pei Y, Chen L, Huang Y, Wang J, Feng J, Xu M, Chen Y, Song Q, Jiang G, Gu X, Zhang Q, Gao X* （通讯作者）, Chen J*. Sequential Targeting TGF-beta Signaling and KRAS Mutation Increases Therapeutic Efficacy in Pancreatic Cancer SMALL 2019 15(24):e**
Jiang T, Chen L, Huang Y, Wang J, Xu M, Zhou S, Gu X, Chen Y, Liang K, Pei Y, Song Q, Liu S, Ma F, Lu H, Gao X* （通讯作者）, Chen J*. Metformin and Docosahexaenoic Acid Hybrid Micelles for Premetastatic Niche Modulation and Tumor Metastasis Suppression. NANO LETT 2019 19(6):3548-3562
Zheng M, Huang M, Ma X, Chen H, Gao X* （通讯作者） Harnessing Exosomes for the Development of Brain Drug Delivery Systems Bioconjug Chem 2019 30(4):994-1005
Wei D, Pang K, Song Q, Suo Y, He H, Weng X, Gao X* （通讯作者）, Wei X* Noninvasive monitoring of nanoparticle clearance and aggregation in blood circulation by in vivo flow cytometry J Control Release 2018 278:66-73.
Ma X, Song Q, Gao X* （通讯作者） Reconstituted high-density lipoproteins novel biomimetic nanocarriers for drug delivery Acta Pharmaceutica Sinica B 2018 8(1):51–63
Huang J, Chen H, Gao X* （通讯作者） Lipid-coated calcium phosphate nanoparticle and beyond: a versatile platform for drug delivery J Drug Target 2018 26(5-6):398-406.
Song H, Ma X, Xu J, Song Q, Hu M, Gu X, Zhang Q, Hou L, Chen L, Huang Y, Yu P, Wang D, Jiang G, Huang M, Chen J, Chen H*, Gao X* （通讯作者） The shape effect of reconstituted high-density lipoprotein nanocarriers on brain delivery and Aβ clearance Nano Research 2018 11(10): 5615–5628
Kang T, Huang Y, Zhu Q, Cheng H, Pei Y, Feng J, Xu M, Jiang G, Song Q, Jiang T, Chen H, Gao X* （通讯作者）, Chen J* Necroptotic cancer cells-mimicry nanovaccine boosts anti-tumor immunity with tailored immune-stimulatory modality Biomaterials 2018 164:80-97.
Huang J, Jiang G, Song Q, Gu X, Hu M, Wang X, Song H, Chen L, Lin Y, Jiang D, Chen J, Feng J, Qiu Y, Jiang J, Jiang X, Chen H*, Gao X* （通讯作者） Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis Nat Commun 2017 8: 15144
Kang T, Zhu Q, Wei D, Feng J, Yao J, Jiang T, Song Q, Wei X, Chen H, Gao X* （通讯作者）, Chen J* Nanoparticles coated with neutrophil membranes can effectively treat cancer metastasis ACS Nano 2017 11(2):1397-1411
Kang T, Zhu Q, Jiang D, Feng X, Feng J, Jiang T, Yao J, Jing Y, Song Q, Jiang X, Gao X* （通讯作者）, Chen J* Synergistic targeting tenascin C and neuropilin-1 for specific penetration of nanoparticles for anti-glioblastoma treatment Biomaterials 2016 101:60-75
Yao L, Gu X, Song Q, Wang X, Huang M, Hu M, Hou L, Kang T, Chen J, Chen H, Gao X. （通讯作者） Nanoformulated alpha-mangostin ameliorates Alzheimer's disease neuropathology by elevating LDLR expression and accelerating amyloid-beta clearance J Control Release 2016 226:1-14
Feng X, Jiang D, Kang T, Yao J, Jing Y, Jiang T, Feng J, Zhu Q, Song Q, Dong N, Gao X* （通讯作者）, Chen J*. Tumor-Homing and Penetrating Peptide-Functionalized Photosensitizer-Conjugated PEG-PLA Nanoparticles for Chemo-Photodynamic Combination Therapy of Drug-Resistant Cancer ACS Appl Mater Interfaces 2016 8(28):17817-32
Huang J, Jiang G, Song Q, Gu X, Song H, Wang X, Jiang D, Kang T, Feng X, Jiang X, Chen H*, Gao X* （通讯作者） High-density lipoprotein-biomimetic nanocarriers for glioblastoma-targeting delivery: the effect of shape Pharmazie 2016 71(12)：709-714
Song Q, Song H, Xu J, Huang J, Hu M, Gu X, Chen J, Zheng G, Chen H*, Gao X*. （通讯作者） Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood-Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery Mol Pharm 2016 13(11):3976-3987
Gu X, Chen H, Gao X*. （通讯作者） Nanotherapeutic strategies for the treatment of Alzheimer's disease Therapeutics delivery 2015 6(2):177-95.
Huang M, Hu M, Song Q, Song H, Huang J, Gu X, Wang X, Chen J, Kang T, Feng X, Jiang D, Zheng G, Chen H*, Gao X*. （通讯作者） GM1-Modified Lipoprotein-like Nanoparticle: Multifunctional Nanoplatform for the Combination Therapy of Alzheimer's Disease ACS Nano 2015 9(11):10801-16.
Wang X, Gu X, Song H, Song Q, Gao X* （通讯作者）, Lu Y*, Chen H*. Phenylmethanesulfonyl fluoride pretreatment stabilizes plasma lipidome in lipidomic and metabolomic analysis Anal Chim Acta. 2015 893:77-83.
Miao D, Jiang M, Liu Z, Gu G, Hu Q, Kang T, Song Q, Yao L, Li W, Gao X* （通讯作者）, Sun M, Chen J* Co-administration of Dual-Targeting Nanoparticles with Penetration Enhancement Peptide for Antiglioblastoma Therapy. Mol Pharm 2014 11(1):90-101
Yao L, Song Q, Bai W, Zhang J, Miao D, Jiang M, Wang Y, Shen Z, Hu Q, Gu X, Huang M, Zheng G, Gao X* （通讯作者）, Hu B*, Chen J*, Chen H* Facilitated brain delivery of poly (ethylene glycol)-poly (lactic acid) nanoparticles by microbubble-enhanced unfocused ultrasound Biomaterials 2014 35(10):3384-95
Song Q, Huang M, Yao L, Wang X, Gu X, Chen J, Chen J, Huang J, Hu Q, Kang T, Rong Z, Qi H, Zheng G*, Chen H*, Gao X* （通讯作者） Lipoprotein-Based Nanoparticles Rescue the Memory Loss of Mice with Alzheimer's Disease by Accelerating the Clearance of Amyloid-Beta ACS Nano 2014 8(3):2345-2359
Song Q, Wang X, Hu Q, Huang M, Yao L, Qi H, Qiu Y, Jiang X, Chen J*, Chen H*, Gao X* （通讯作者） Cellular internalization pathway and transcellular transport of pegylated polyester nanoparticles in Caco-2 cells Int J Pharm 2013 445: 58-68
Gu G, Xia H, Hu Q, Liu Z, Jiang M, Kang T, Miao D, Tu Y, Pang Z, Song Q, Yao L, Chen H, Gao X* （通讯作者）, Chen J* PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy Biomaterials 2013 34(1):196-208
Hu Q, Gu G, Liu Z, Jiang M, Kang T, Miao D, Tu Y, Pang Z, Song Q, Yao L, Xia H, Chen H, Jiang X, Gao X* （通讯作者）, Chen J* F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery Biomaterials 2013 34(4):1135-1145
Xia H, Gu G, Hu Q, Liu Z, Jiang M, Kang T, Miao D, Song Q, Yao L, Tu Y, Chen H, Gao X* （通讯作者）, Chen J* Activatable cell penetrating peptide-conjugated nanoparticles with enhanced permeability for site-specific targeting delivery of anticancer drug Bioconjug Chem 2013 24(3):419-430
Liu Z, Jiang M, Kang T, Miao D, Gu G, Song Q, Yao L, Hu Q, Tu Y, Pang Z, Chen H, Jiang X, Gao X* （通讯作者）, Chen J* Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration Biomaterials 2013 34(15):3870-3881
Xia H, Gao X （共同第一作者）, Gu G, Liu Z, Hu Q, Tu Y, Song Q, Yao L, Pang Z, Jiang X, Chen J, Chen H. Penetratin-functionalized PEG-PLA nanoparticles for brain drug delivery. Int J Pharm. 2012 15;436(1-2):840-50
Song Q, Yao L, Huang M, Hu Q, Lu Q, Wu B, Qi H, Rong Z, Jiang X, Gao X （通讯作者）, Chen J, Chen H. Mechanisms of transcellular transport of wheat germ agglutinin-functionalized polymeric nanoparticles in Caco-2 cells. Biomaterials 2012 33:6769-82.
Zeng N, Gao X （共同第一作者）, Hu Q, Song Q, Xia H, Liu Z, Gu G, Jiang M, Pang Z, Chen H, Chen J, Fang L. Lipid-based liquid crystalline nanoparticles as oral drug delivery vehicles for poorly water-soluble drugs: cellular interaction and in vivo absorption. Int J Nanomed 2012 7:3703-18.
Gao X, Yao L, Song Q, Zhu L, Xia Z, Xia H, Jiang X, Chen J, Chen H The association of autophagy with polyethylenimine-induced cytotoxity in nephritic and hepatic cell lines Biomaterials 2011 32(33):8613-25
Guo J, Gao X （共同第一作者）, Su L, Xia H, Gu G, Pang Z, Jiang X, Yao L, Chen J, Chen H Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery Biomaterials 2011 32(31):8010-20
Xia H, Gao X （共同第一作者）, Gu G, Liu Z,Zeng N,Hu Q, Song Q, Yao L,Pang Z, Jiang X, Chen J, Chen H Low molecular weight protamine-functionalized nanoparticles for brain drug delivery after intranasal administration Biomaterials 2011 32(36):9888-98
Zhang XY, Chen J, Zheng YF, Gao XL Follicle-stimulating hormone peptide can facilitate paclitaxel nanoparticles to target ovarian carcinoma in vivo Cancer Res 2009 69(16):6506-6514
Hu K, Li J, Shen Y, Lu W, Gao X, Zhang Q, Jiang X Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations J Control Release 2009 134(1):55-61
Xu F, Lu W, Wu H, Fan L, Gao X, Jiang X Brain delivery and systemic effect of cationic albumin conjugated PLGA nanoparticles J Drug Target 2009 17(6):423-34
Gao X, Wang T, Wu B, Chen J, Chen J, Yue Y, Dai N, Chen H, Jiang X Quantum dots for tracking cellular transport of lectin-functionalized nanoparticles Biochem Biophys Res Commun 2008 377(1): 35-40
Chen J, Gao X, Hu K, Pang Z, Cai J, Li J, Wu H, Jiang X Galactose-poly(ethylene glycol)-polyethylenimine for improved lung gene transfer Biochem Biophys Res Commun 2008 375(3):378-83
Gao X, Chen J, Chen J, Wu B, Chen H, Jiang X. Quantum dots bearing lectin-functionalized nanoparticles as a platform for in vivo brain imaging Bioconjug Chem 2008 19(11):2189-2195
Pang Z, Lu W, Gao H, Hu K, Chen J, Zhang C, Gao X, Jiang X, Zhu C Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26 J Control Release 2008 128(2):120-7
Gao X, Wu B, Zhang Q, Chen J, Zhu J, Zhang W, Rong Z, Chen H, Jiang X Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration J Control Release 2007 121:156-167
Gao X, Chen J, Tao W, Zhu J, Zhang Q, Chen H, Jiang X UEA I-bearing nanoparticles for brain delivery following intranasal administrationadministration Int J Pharm 2007 340:207-215
Gao X, Tao W, Lu W, Zhang Q, Zhang Y, Jiang X, Fu S Lectin-conjugated PEG-PLA nanoparticles: Preparation and brain delivery after intranasal administration Biomaterials 2006 27:3482-3490
Gao X, Chen J, Mei N, Tao W, Jiang W, Jiang X HPLC Determination and pharmacokinetic study of indapamide in human whole blood Chromatographia 2005 61:581-585