导师姓名： 邵荣 专业代码： 100700
性别： 男 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： rongshao@sjtu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤分子生物学，转化医学，靶向新药研发

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 面上项目 中国自然科学基金 2018-01~2021-12 58万元 课题负责人
N/A 首席科学家启动计划 上海交通大学附属新华医院 2017-06~2020-05 80万元 课题负责人
N/A YKL-40在子宫癌的作用 泰国研究基金会 2015-05~2017-03 12万元 课题负责人
N/A YKL-40在脑肿瘤发展中的机制 马萨诸塞州约翰?亚当斯创新研究所 2012-03~2013-02 21万元 课题负责人
DE-FOA-** PVLSI转化生物医学研究 美国能源部(DoE) 2010-06~2011-05 245万元 课题负责人
R01CA120659 血管生成因子YKL-40在乳腺癌进展的作用 美国国立卫生研究院(NIH)R01 2008-05~2014-04 790万元 课题负责人
** PVLSI乳腺癌研究项目：生物标志物和化学预防 美国国防部(DoD) 2006-01~2010-12 317万元 课题负责人
DAMD17-00-1-0228 TPF在乳房癌血管生成的机制 美国国防部(DoD) 2000-06~2003-05 105万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
YP. Hu, YP. Jin, XS. Wu , Y. Yang, YS. Li, HF. Li, SS. Xiang, XL. Song, L. Jiang, YJ. Zhang, W. Huang, Sl. Chen, FT. Liu, C. Chen, Q. Zhu, HZ. Chen, R. Shao （通讯作者）, YB Liu. LncRNA-HGBC promotes gallbladder cancer metastasis via removing miR-503p from target gene SAT Mol. Cancer. 2019 18: 167
N. Xu, J. Liang, R. Shao, Q. Bo, Y. Zhai, S. Yang, X. Luo, X.Sun Chitinase 3-like-1 promotes M1 to M2 macrophage differentiation and coordinates with VEGF to induce choroidal neovascularization in age-related macular degeneration. Invest. Ophth. Vis. Sci. 2019 60: 4596-4605
N. Ngernyuang, W. Yan, LM. Schwartz, D. Oh, Y-B Liu, H. Chen, R. Shao （通讯作者） A heparin binding motif rich in arginine and lysine is the functional domain of angiogenic factor YKL-40. Neoplasia 2018 20: 182-192
N. Ngernyuang, K. Suwannarurk, R. Shao, T. Limpaiboon. Chitinase 3 like 1 （YKL-40）promotes vasculogenic mimicry formation in cervical cancer Pathology 2018 50: 293-297
R. Shao （通讯作者） Secreted glycoprotein YKL-40: A potential cancer biomarker and therapeutic target Integr Cancer Sci Ther 2018 5:1
A. Shenoy, Y. Jin, H. Luo, M. Tang, C. Pampo, R. Shao, D.Siemann, L. Wu, C. Heldermon, B. Law, L. Chang, J. Lu. Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells. J. Clin. Invest. 2016 126:4174-4186
R. Shao （通讯作者）, S. Taylor, D. Oh, L. Schwartz. Vascular heterogeneity: role of YKL-40 in glioblastoma vascularization Oncotarget 2015 6: 40507-40518
N. Ngernyuang, R. Francescone, P. Jearanikoon, J. Daduang, A. Supoken, W. Yan, R. Shao, T.Limpaiboon Limpaiboon. Chitinase 3 like 1 (YKL-40) is associated with tumor angiogenesis in cervical cancer. Int. J. Biochem. Cell Bio. 2014 51:45-52,
R. Shao （通讯作者）, R. Francescone, N. Ngernyuang, B. Bentley, S. Taylor, L. Moral, W. Yan. Anti-YKL-40 antibody and ionizing irradiation synergistically inhibit tumor vascularization and malignancy in glioblastoma Carcinogenesis 2014 35:373-382
R. Francescone, N. Ngernyuang, W. Yan, B. Bentley, R. Shao. （通讯作者） Tumor-derived mural-like cells coordinate with endothelial cells: role of YKL-40 in mural cell-mediated angiogenesis. Oncogene 2014 33: 2100-2122
R. Shao. （通讯作者） YKL-40 acts as an angiogenic factor to promote tumor angiogenesis. Front. Physiol. 2013 4: 122, 1-9
R. Shao （通讯作者）, S. Scully, W. Yan, B. Bentley, J. Mueller, C. Brown, C. Bigelow, L. Schwartz. The novel lupus antigen protein Acheron enhances the development of human breast cancer. Inter. J. Cancer 2012 130: 544-554
S. Scully, R. Francescone, M. Faibish, B. Bentley, S. L. Taylor, D. Oh, R. Schapiro, L. Moral, W. Yan, R. Shao. （通讯作者） Transdifferentiation of glioblastoma stem-like cells into mural cells drives vasculogenic mimicry in glioblastomas. J. Neurosci. 2012 32: 12950-12960
R. Francescone, S. Scully, B. Bentley, W. Yan, S. Taylor, D. Oh, L. Moral, R. Shao. （通讯作者） Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 activation. J. Biol. Chem. 2012 287: 24821-24831,
A. Bourdiec, R. Shao, C.V. Rao, A. Akoum. Human chorionic gonadotropin triggers angiogenesis via the modulation of endometrial stromal cell responsiveness to interleukin 1: a new possible mechanism underlying embryo implantation. Biol. Reprod. 2012 87 (3) 66: 1-10,
R. Francescone, S. Scully, M. Faibish, S. Taylor, D. Oh, L. Moral, W. Yan, B. Bentley, R. Shao. （通讯作者） The role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. J. Biol. Chem. 2011 286: 15332-15343
S. Scully, W. Yan, B. Bentley, Q.J. Cao, R. Shao. （通讯作者） Inhibitory activity of YKL-40 in mammary epithelial cell differentiation and polarization induced by lactogenic hormones: a role in mammary tissue involution. PLoS ONE 2011 6: e25819
R. Shao （通讯作者）, Q.J. Cao, R. B. Arenas, C. Bigelow, B. Bentley, W. Yan. Breast cancer expression of YKL-40 correlates with tumor grade, poor differentiation and other cancer markers. Br. J. Cancer 2011 105: 1203-1209
R. Francescone, M. Faibish, R. Shao. （通讯作者） A Matrigel-based tube formation assay to assess the vasculogenic activity of tumor cells. J. Vis. Exp. 2011 55: 3040
M. Faibish, R. Francescone, B. Bentley, W. Yan, R. Shao. （通讯作者） A YKL-40 neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancers Mol. Cancer Ther. 2011 10: 742-751
W. Yan, J. Cao, R. Arenas, B. Bentley, R. Shao. （通讯作者） GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition. J. Biol. Chem. 2010 285: 14042-14051
R. Shao （通讯作者）, K. Hamel, L. Petersen, J. Cao, R. B. Arenas, C. Bigelow, B. Bentley, W. Yan. YKL-40, a secreted glycoprotein, promotes tumor angiogenesis. Oncogene 2009 28: 4456-4468
P. Apopa, Y. Qian, R. Shao, N. Guo, D. Schwegler-Berry, M. Pacurari, D. Porter, X. Shi, V. Vallyathan, V. Castranova, D. Flynn. Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling. Particle Fibre Toxicol. 2009 6: 1-14
A. Khimji, R. Shao, D. C. Rockey. Divergent Transforming Growth Factor-β Signaling in Hepatic Stellate Cells after Liver Injury. Am. J. Pathol. 2008 173: 716-727,
W. Yan, B. Bentley, R. Shao. （通讯作者） Distinct angiogenic mediators are required for bFGF and VEGF-induced angiogenesis: the role of cytoplasmic tyrosine kinase c-Abl in tumor angiogenesis. Mol. Biol. Cell 2008 19: 2278-2288
W. Yan, R. Shao. （通讯作者） Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation. J. Biol. Chem. 2006 281: 19700-19708
R. Shao （通讯作者）, Xing Guo. Human microvascular endothelial cells immortalized with hTERT: a model for the study of in vitro angiogenesis. Biochem. Bioph. Res. Co. 2004 321, 788-794
S. Bao, G. Ouyang, X. Bai, H. Zhi, C. Ma, M. Liu, R. Shao, R. Anderson, J. N. Rich, X-F. Wang. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell 2004 5: 329-339
R. Shao, S. Bao, X. Bai, C. Blanchette, R. Anderson, J. R. Mark, X-F. Wang. Acquired expression of periostin by breast cancers promotes tumor progression via enhancement of angiogenesis. Mol. Cell. Biol. 2004 24: 3992-4003
R. Shao, Z. Shi, P.J. Gotwals, V.E. Koteliansky, D.C.Rockey. Cell and molecular regulation of endothelin-1 production during hepatic wound healing. Mol. Biol. Cell 2003 14: 2327-2341
R. Shao, D.C. Rockey. Effects of endothelins on hepatic stallate cell synthesis of endothelin-1 during hepatic wound healing. J. Cell. Physiol. 2002 191: 342-350
C. Hubbert, A. Guardiola, R. Shao, Y. Kawaguchi, A. Ito, A. Nixon, M. Yoshida, X-F. Wang, T-P. Yao. HDAC6 is a microtubule-associated deacetylase. Nature 2002 417: 455-458
Q. Yu, R. Shao, H.S. Qian, S.E. George, D.C. Rockey. Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension. J. Clin. Invest. 2000 105: 741-748
R. Shao, W. Yan, D. C. Rockey. Endothelin production is regulated by endothelin converting enzyme-1 in hepatic wound healing. J. Biol. Chem. 1999 274: 3228-3234