导师姓名： 陈红专 专业代码： 100700
性别： 男 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： -778015
邮编： 200025 邮箱地址： yaoli@shsmu.edu.cn

研究方向 (点击浏览详细信息)
神经退行性病、肿瘤等重大疾病新靶点和新药的转化药理学研究

社会任职
全国政协委员; 民盟上海市委副主委；上海市浦东新区人大副主任；国务院学科评议组成员，中国药理学会荣誉理事、上海药理学会名誉理事长、上海市药学会副理事长兼药理专业委员会主任。Mol Pharmacol、CNS Neurosci & Therapy、Acta Pharmacol Sin、 Transl Neurodegener等SCI杂志编委。

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** M1受体选择性激活和Gαq-PKC信号偏好的变构新位点发掘 国家自然科学基金面上项目 2019-01~2022-12 60万元 课题负责人
** 乙酰胆碱酯酶新基序AChE7-20非酶活性依赖的海马神经元毒性调控机制 国家自然科学基金面上项目 2016-01~2019-12 72万元 课题负责人
2012ZX09303-003 精神药物新药临床评价研究技术平台-精神药物转化医学研究 国家“新药创制”科技重大专项 2012-01~2015-12 50万元 课题负责人
** 乙酰胆碱受体及亚型在肺腺癌干细胞中的信号网络调控和代谢组学研究 国家自然科学基金面上项目 2012-01~2015-12 55万元 课题负责人
2011DFA33180 AMPA受体和M1受体协同调控机制及靶标药物研究 科技部国际合作专项(中美合作) 2012-01~2014-12 180万元 课题负责人
2012ZX09303-003 精神药物新药临床评价研究技术平台-精神药物转化医学研究 国家“新药创制”科技重大专项 2012-01~2015-12 50万元 课题负责人
** 乙酰胆碱受体及亚型在肺腺癌干细胞中的信号网络调控和代谢组学研究 国家自然科学基金面上项目 2012-01~2015-12 55万元 课题负责人
基于老年性痴呆早期诊疗的仿生高密度脂蛋白纳米载体构建和药理学研究 上海市科委（中加合作） 2011-01~2013-12 50万元 课题负责人
** 分子伴侣AChE诱导Aβ寡聚体形成的动力学和膜离子通道改变的研究 国家自然基金面上项目 2010-01~2012-12 32万元 课题负责人
2010CB529806 重要药用前景动物多肽毒素的临床应用基础研究 国家重点基础研究（973计划子项目） 2010-01~2014-12 427万元 课题负责人
2009ZX09103-077 具有多靶点作用抗老年性痴呆候选药物XQ509的研究 国家“新药创制”科技重大专项 2009-06~2011-06 150万元 课题负责人
8 具有多靶点作用抗老年性新型美普他酚系列双配基衍生物治疗阿尔茨海默病的化学生物学研究 教育部博士点基金 2009-01~2010-12 8万元 课题负责人
** 新型双配基AChE抑制剂的结构、性质和效应的关系 国家自然基金委面上项目 2008-01~2010-12 37万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhao LX, Ge YH, Li JB, Xiong CH, Law PY, Xu JR, Qiu Y, Chen HZ. （通讯作者） M1 muB3:O5scarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 33(5):6622-6631.
Hu YB, Ren RJ, Zhang YF, Huang Y, Cui HL, Ma C, Qiu WY, Wang H, Cui PJ, Chen HZ （通讯作者）, Wang G. Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology. Aging Cell. 2019 18(5):e13001
Xu J, Tan P, Li H, Cui Y, Qiu Y, Wang H, Zhang X, Li J, Zhu L, Zhou W, Chen H. （通讯作者） Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand-binding affinity and signal transduction FASEB J. 2019 33(3):3237-3251.
Yu Z, Dou F, Wang Y, Hou L, Chen H. （通讯作者） Ca2+-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling. J Neuroinflammation. 2018 15(1):316.
Luan X, Guan YY, Liu HJ, Lu Q, Zhao M, Sun D, Lovell JF, Sun P, Chen HZ （通讯作者）, Fang C. A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem that Induces and Exploits Hypoxia Adv Sci 2018 5(8):**.
Yue J, Lv D, Wang C, Li L, Zhao Q, Chen H （通讯作者）, Xu L. Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin β3 Oncogene. 2018 37(31):4300-4312.
Song H, Ma X, Xu J, Song Q, Hu M, Gu X, Zhang Q, Hou L, Chen L, Huang Y, Yu P, Wang D, Jiang G, Huang M, Chen J, Chen H （通讯作者）, Gao X The shape effect of reconstituted high-density lipoprotein nanocarriers on brain delivery and Aβ clearance Nano Research 2018 11, 5615–5628
Zhao LX, Ge YH, Xiong CH, Tang L, Yan YH, Law PY, Qiu Y, Chen HZ. （通讯作者） M1 muscarinic receptor facilitates cognitive function by interplay with AMPA receptor GluA1 subunit FASEB J. 2018 32(8):4247-4257.
Dong JK, Lei HM, Liang Q, Tang YB, Zhou Y, Wang Y, Zhang S, Li WB, Tong Y, Zhuang G, Zhang L, Chen HZ （通讯作者）, Zhu L, Shen Y. Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase. Theranostics. 2018 8(7):1808-1823.
Kang T, Zhu Q, Wei D, Feng J, Yao J, Jiang T, Song Q, Wei X, Chen H, Gao X, Chen J Nanoparticles Coated with Neutrophil Membranes Can Effectively Treat Cancer Metastasis ACS Nano 2017 11(2): 1397~1411
Huang JL, Jiang G, Song QX, Gu X, Hu M, Wang XL, Song HH, Chen LP, Lin YY, Jiang D, Chen J, Feng JF, Qiu YM, Jiang JY, Jiang XG, Chen HZ （通讯作者）, Gao XL. Lipoprotein-Biomimetic Nanostructure Enables Efficient Targeting Delivery of siRNA to Ras-Activated Nature Communications 2017 8:15144.
Yi M, Wei T, Wang Y, Lu Q, Chen G, Gao X, Geller HM, Chen H （通讯作者）, Yu Z. The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke J Neuroinflammation. 2017 14(1):203.
Teng L, Lei HM, Sun F, An SM, Tang YB, Meng S, Wang CH, Shen Y, Chen HZ （通讯作者）, Zhu L. Autocrine glutamatergic transmission for the regulation of embryonal carcinoma stem cells. Oncotarget 2016 7(31):49552-49564.
Wang Y, Wang H, Chen HZ. （通讯作者） AChE Inhibition-based Multi-target-directed Ligands, a Novel Pharmacological Approach for the Symptomatic and Disease-modifying Therapy of Alzheimer's Disease. Curr Neuropharmacol. 2016 14(4):364-75.
Zhang L, Xiao J, Xu J, Fu T, Cao Z, Zhu L, Chen HZ, Shen X, Jiang H, Zhang L. Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis. Cell Res. 2016 26(12):1330-1344.
Zhang C, Ding XP, Zhao QN, Yang XJ, An SM, Wang H, Xu L, Zhu L, Chen HZ. （通讯作者） Role of α7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells. Oncotarget. 2016 7(37):59199-59208.
Yao L, Gu X, Song Q, Wang X, Huang M, Hu M, Hou L, Kang T, Chen J, Chen H （通讯作者）, Gao X. Nanoformulated alpha-mangostin ameliorates Alzheimer's disease neuropathology by elevating LDLR expression and accelerating amyloid-beta clearance. J Control Release. 2016 226:1-14.
Wang Y, Ge YH, Wang YX, Liu T, Law PY, Loh HH, Chen HZ （通讯作者）, Qiu Y. Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12. CNS Neurosci Ther 2015 21(7):591-8
Jiang S, Yang W, Qiu Y, Chen HZ （通讯作者）, Alzheimer's Disease Neuroimaging Initiative (ADNI) Identification of Novel Quantitative Traits-Associated Susceptibility Loci for APOE ε 4 Non-Carriers of Alzheimer's Disease Curr Alzheimer Res 2015 12(3):218-27
Wang Y, Wang YX, Liu T, Law PY, Loh HH, Qiu Y, Chen HZ （通讯作者） μ-Opioid receptor attenuates Aβ oligomers-induced neurotoxicity through mTOR signaling. CNS Neurosci Ther 2015 21(1):8-14
Song Y, Lu HZ, Xu JR, Wang XL, Zhou W, Hou LN, Zhu L, Yu ZH, Chen HZ （通讯作者）, Cui YY. Carbocysteine restores steroid sensitivity by targeting histone deacetylase 2 in a thiol/GSH-dependent manner Pharmacol Res 2015 91:88-98
Zhao Q, Gu X, Zhang C, Lu Q, Chen H （通讯作者）, Xu L Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) Cancer Biol Ther 2015 16(4):634-43
Guan YY, Liu HJ, Luan X, Xu JR, Lu Q, Liu YR, Gao YG, Zhao M, Chen HZ （通讯作者）, Fang C. Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human colorectal tumor by inhibiting VEGFR2 signaling Phytomedicine 2015 22(1):103-10
Yu DH, Liu YR, Luan X, Liu HJ, Gao YG, Wu H, Fang C, Chen HZ （通讯作者） Nanoparticles with IF7-conjugated annexin 1 targets tumor vasculature against P-gp mediated multidrug resistance Bioconjug Chem 2015 26(8):1702-12
Zhao Q, Yue J, Zhang C, Gu X, Chen H （通讯作者）, Xu L Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC) Oncotarget 2015 6(30):29335-46
Yu F, Gong P, Hu Z, Qiu Y, Cui Y, Gao X, Chen H （通讯作者）, Li J. Cu (II) enhances the effect of Alzheimer’s amyloid-β peptide on microglial activation J Neuroinflammation 2015 12:122
Xu J, Zhao H, Zheng Z, Wang Y, Niu Y, Wang H, Xu J, Lu Y, Chen H. （通讯作者） Structural determinants for the interactions between muscarinic toxin 7 and muscarinic acetylcholine receptors J Mol Recognit 2015 28(4):239-52
Liu YR, Guan YY, Luan X, Lu Q, Wang C, Liu HJ, Gao YG, Yang SC, Dong X, Chen HZ （通讯作者）, Fang C. Delta-like ligand 4-targeted nanomedicine for antiangiogenic cancer therapy Biomaterials 2015 42:161-71
Gong Y, Li X, Kang L, Xie Y, Rong Z, Wang H, Qi H, Chen H. （通讯作者） Simultaneous determination of endocannabinoids in murine plasma and brain substructures by surrogate-based LC–MS/MS: Application in tumor-bearing mice J Pharm Biomed Anal 2015 111:57-63
Li B, Li H, Bai Y, Kirschner-Schwabe R, Yang JJ, Chen Y, Lu G, Tzoneva G, Ma X, Wu T, Li W, Lu H, Ding L, Liang H, Huang X, Yang M, Jin L, Kang H, Chen S, Du A, Shen S, Ding J, Chen H, Chen J, von Stackelberg A, Gu L, Zhang J, Ferrando A, Tang J, Wang S, Zhou BB Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL Nat Med 2015 21(6):563-71
Wang X, Gu X, Song H, Song Q, Gao X, Lu Y, Chen H. （通讯作者） Phenylmethanesulfonyl fluoride pretreatment stabilizes plasma lipidome in lipidomic and metabolomic analysis Anal Chim Acta 2015 893:77-83
Sun F, Ding XP, An SM, Tang YB, Yang XJ, Teng L, Zhang C, Shen Y, Chen HZ （通讯作者）, Zhu L Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling. Sci Rep 2015 5:15950
Sun F, Yang XJ, Lv HY, Tang YB, An SM, Ding XP, Li WB, Teng L, Shen Y, Chen HZ （通讯作者）, Zhu L β2‐adrenoreceptor–mediated proliferation inhibition of embryonic pluripotent stem cells J Cell Physiol 2015 230(11):2640-6
Huang M, Hu M, Song Q, Song H, Huang J, Gu X, Wang X, Chen J, Kang T, Feng X, Jiang D, Zheng G, Chen H （通讯作者）, Gao X. GM1-Modified Lipoprotein-like Nanoparticle: Multifunctional Nanoplatform for the Combination Therapy of Alzheimer's Disease. ACS Nano. 2015 9(11):10801-16
Zhao WS, Wang J, Ma XJ, Yang Y, Liu Y, Huang LD, Fan YZ, Cheng XY, Chen HZ, Wang R, Yu Y Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation Nat Commun 2014 5:4189-5189
Song Q, Huang M, Yao L, Wang X, Gu X, Chen J, Chen J, Huang J, Hu Q, Kang T, Rong Z, Qi H, Zheng G, Chen H （通讯作者）, Gao X. Lipoprotein-based nanoparticles rescue the memory loss of mice with Alzheimer's disease by accelerating the clearance of amyloid-beta. ACS Nano 2014 8(3):2345-59
Hu Z, Yu F, Gong P, Qiu Y, Zhou W, Cui Y, Li J, Chen H （通讯作者） Subneurotoxic copper(II)-induced NF-κB-dependent microglial activation is associated with mitochondrial ROS Toxicol Appl Pharmacol 2014 276(2):95-103
Yao L, Song Q, Bai W, Zhang J, Miao D, Jiang M, Wang Y, Shen Z, Hu Q, Gu X, Huang M, Zheng G, Gao X, Hu B, Chen J, Chen H. （通讯作者） Facilitated brain delivery of poly (ethylene glycol)-poly (lactic acid) nanoparticles by microbubble-enhanced unfocused ultrasound Biomaterials 2014 35(10):3384-95
Tan PP, Yuan HH, Zhu X, Cui YY, Li H, Feng XM, Qiu Y, Chen HZ （通讯作者）, Zhou W. Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models CNS Neurosci Ther 2014 20(3):227-36
Hou LN, Xu JR, Zhao QN, Gao XL, Cui YY, Xu J, Wang H, Chen HZ （通讯作者） A New Motif in the N-Terminal of Acetylcholinesterase Triggers Amyloid-β Aggregation and Deposition CNS Neurosci Ther 2014 20(1):59-66
Shao BY, Xia Z, Xie Q, Ge XX, Zhang WW, Sun J, Jiang P, Wang H, Le WD, Qiu ZB, Lu Y, Chen HZ. （通讯作者） Meserine, a novel carbamate AChE inhibitor, ameliorates scopolamine-induced dementia and alleviates amyloidogenesis of APP/PS1 transgenic mice CNS Neurosci Ther 2014 20(2):165-71
Teng L, Tang YB, Sun F, An SM, Zhang C, Yang XJ, Lv HY, Lu Q, Cui YY, Hu JJ, Zhu L, Chen HZ. （通讯作者） Non-neuronal release of gamma-aminobutyric Acid by embryonic pluripotent stem cells. Stem Cells Dev 2013 22(22):2944-53
Song Q, Wang X, Hu Q, Huang M, Yao L, Qi H, Qiu Y, Jiang X, Chen J, Chen H （通讯作者）, Gao X Cellular internalization pathway and transcellular transport of pegylated polyester nanoparticles in Caco-2 cells Int J Pharm 2013 445(1-2):58-68
Liu T, Xia Z, Zhang WW, Xu JR, Ge XX, Li J, Cui Y, Qiu ZB, Xu J, Xie Q, Wang H, Chen HZ （通讯作者） Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice Pharmacol Biochem Behav 2013 104:138-43
Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zhao Q, Zhou AW, Wang LS, Sun HD, Chen GQ Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells Nat Chem Biol 2012 8(5):486-93
Ge XX, Wang XL, Jiang P, Xie Y, Jiang T, Rong ZX, Zhang QZ, Xie Q, Qiu ZB, Wang H, Chen HZ. （通讯作者） Determination of Bis(9)-(-)-Meptazinol, a bis-ligand for Alzheimer's disease, in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetics study J Chromatogr B 2012 881-882:126-30
Wang Y, Xia Z, Xu JR, Wang YX, Hou LN, Qiu Y, Chen HZ. （通讯作者） α-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation. Neuropharmacology 2012 62(2):871-81
Xia H, Gao X, Gu G, Liu Z, Hu Q, Tu Y, Song Q, Yao L, Pang Z, Jiang X, Chen J, Chen H. （通讯作者） Penetratin-functionalized PEG-PLA nanoparticles for brain drug delivery. Int J Pharm 2012 436(1-2):840-50.
Song Q, Yao L, Huang M, Hu Q, Lu Q, Wu B, Qi H, Rong Z, Jiang X, Gao X, Chen J, Chen H （通讯作者） Mechanisms of transcellular transport of wheat germ agglutinin-functionalized polymeric nanoparticles in Caco-2 cells Biomaterials 2012 33(28):6769-82
Zheng W, Li J, Qiu Z, Xia Z, Li W, Yu L, Chen H, Chen J, Chen Y, Hu Z, Zhou W, Shao B, Cui Y, Xie Q, Chen H. （通讯作者） Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property. Toxicol Appl Pharmacol 2012 264(1):65-72.
Peng L, Jiang T, Rong Z, Liu T, Wang H, Shao B, Ma J, Yang L, Kang L, Shen Y, Li H, Qi H, Chen H. （通讯作者） Surrogate based accurate quantification of endogenous acetylcholine in murine brain by hydrophilic interaction liquid chromatography-tandem mass spectrometry. J Chromatogr B 2011 879(32):3927-31
Qiu Y, Wang Y, Law PY, Chen HZ （通讯作者）, Loh HH. Cholesterol regulates micro-opioid receptor-induced beta-arrestin 2 translocation to membrane lipid rafts. Mol Pharmacol. 2011 80(1):210-8
Gao X, Yao L, Song Q, Zhu L, Xia Z, Xia H, Jiang X, Chen J, Chen H. （通讯作者） The association of autophagy with polyethylenimine-induced cytotoxity in nephritic and hepatic cell lines. Biomaterials 2011 32(33):8613-25.
Jiang T, Rong Z, Peng L, Chen B, Xie Y, Chen C, Sun J, Xu Y, Lu Y, Chen H. （通讯作者） Simultaneous determination of citalopram and its metabolite in human plasma by LC-MS/MS applied to pharmacokinetic study. J Chromatogr 2010 878(5-6):615-9
Cui Y, Devillier P, Kuang X, Wang H, Zhu L, Xu Z, Xia Z, Zemoura L, Advenier C, Chen H. （通讯作者） Tiotropium reduces lung inflammation in a model of chronic gastro-oesophageal reflux. Eur Respir J. 2010 35(6):1370-6
Yu DH, Lu Q, Xie J, Fang C, Chen HZ. （通讯作者） Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature Biomaterials 2010 31(8):2278-2292
Liu F, Fang C, Ye X, Lu Q, Yu DH, Zhang WW, Qi H, Xie J, Lieber A, Chen HZ （通讯作者） Anti-4-1BB scFv immunogene therapy and low dose cyclophosphamide exhibit a synergistic antitumor effect in established murine lung tumors Cancer Biol Ther 2009 8(8):707-713
Qi H, Ma J, Liu YM, Yang L, Peng L, Wang H, Chen HZ （通讯作者） Allostatic tumor-burden induces depression-associated changes in hepatoma-bearing mice. J Neurooncol 2009 94(3):367-372
Zhu X, Zhou W, Cui YY, Zhu L, Li J, Xia Z, Shao B, Wang H, Chen H （通讯作者） Muscarinic activation attenuates abnormal processing of beta-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells Biochem Biophys Res Commun 2009 384(1):110-113
Lu Q, Yu DH, Fang C, Liu F, Ye X, Zhao Y, Qin J, Guo XK, Liang M, Hu F, Chen HZ （通讯作者） Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells. Cancer Biol Ther 2009 8(12):1125-1132
Miezan Ezoulin JM, Shao BY, Xia Z, Xie Q, Li J, Cui YY, Wang H, Dong CZ, Zhao YX, Massicot F, Qiu ZB, Heymans F, Chen HZ （通讯作者） Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice Int J Neuropsychopharmacol 2009 12(10):1409-1419
Fu J, Feng X, Yuan H, Yan L, Kuang X, Xia Z, Gao X, Yu C, Lu Y, Chen HZ. （通讯作者） Study of ocular pharmacokinetics of in situ gel system for S(-)-satropane evaluated by microdialysis J Pharm Biomed Anal 2008 48(3):840-843
Xie Q, Wang H, Xia Z, Lu MY, Zhang WW, Wang XH, Fu Wei, Tang Y, Sheng W, Li W, Zhou W, Zhu X, Qiu ZB, Chen HZ. （通讯作者） Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on Amyloid-β aggregation. J Med Chem 2008 51(7):2027-2036
Ren Z, Ye X, Fang C, Lu Q, Zhao Y, Liu F, Liang M, Hu F, Chen HZ （通讯作者） Intratumor injection of oncolytic adenovirus expressing HSP70 prolonged survival in melanoma B16 bearing mice by enhanced immune response.immunocompetent mice. Cancer Biol Ther. 2008 7(2):191-195
Song MK, Liu H, Jiang HL, Yue JM, Hu GY, Chen HZ. （通讯作者） Discovery of talatisamine as a novel specific blocker for the delayed rectifier K(+) channels in rat hippocampal neurons. Neuroscience. 2008 155(2):469-475
Liu F, Lu Q, Ye X, Fang C, Zhao Y, Liang M, Hu F, Lieber A, Chen HZ. （通讯作者） Cancer gene therapy of adenovirus-mediated anti-4-1BB scFv in immunocompetent mice. Cancer Biol Ther. 2008 7(3):448-453
Gao X, Chen J, Chen J, Wu B, Chen H （通讯作者）, Jiang X. Quantum dots bearing lectin-functionalized nanoparticles as a platform for in vivo brain imaging Bioconjug Chem. 2008 19(11):2189-2195
Gao X, Wang T, Wu B, Chen J, Chen J, Yue Y, Dai N, Chen H （通讯作者）, Jiang X Quantum dots for tracking cellular transport of lectin-functionalized nanoparticles. Biochem Biophys Res Commun 2008 377(1):35-40
Fang C, Liu Y, Ye X, Rong ZX, Feng XM, Jiang CB, Chen HZ. （通讯作者） Synergistically enhanced transdermal permeation and topical analgesia of tetracaine gel containing menthol and ethanol in experimental and clinical studies. Eur J Pharm Biopharm. 2008 68(3):735-740
Li J, Shao B, Zhu L, Cui Y, Dong C, Miezan Ezoulin JM, Gao X, Ren Q, Heymans F, Chen HZ. （通讯作者） PMS777, A Bis-interacting Ligand for PAF Receptor Antagonism and AChE Inhibition, Attenuates PAF-induced Neurocytotoxicity in SH-SY5Y Cells. Cell Mol Neurobiol 2008 28(1):125-136
Zhou W, Zhu X, Zhu L, Cui YY, Wang H, Qi H, Ren QS, Chen HZ. （通讯作者） Neuroprotection of Muscarinic Receptor Agonist Pilocarpine Against Glutamate-induced Apoptosis in Retinal Neurons Cell Mol Neurobiol 2008 28(2):263-275