导师姓名： 邱瑜 专业代码： 100700
性别： 女 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市重庆南路280号三号楼303室，email:yu_qiu@hotmail.com, qiuy@shsmu.edu.cn
邮编： 200025 邮箱地址： yu_qiu@hotmail.com

研究方向 (点击浏览详细信息)
阿尔茨海默病病理生理机制与药物靶标

社会任职
上海市药理学会会员
美国药理学与治疗学学会会员
中国药理学会会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 核糖体蛋白S6激酶p85S6K与AMPA受体GluA1亚基的相互作用及其对学习记忆的调控 国家自然科学基金 2019-01~2022-12 68.1万元 课题负责人
YG2017ZD14 中药有效成分α-倒捻子素抗阿尔茨海默病药理学研究和新药开发 上海交通大学医工交叉重点项目 2018-01~2020-12 50万元 课题负责人
** M1胆碱受体对AMPA受体GluA1亚基的调控及其在突触长时程增强和学习记忆中的作用及机制 国家自然科学基金 2015-01~2018-12 70万元 课题负责人
** FKBP12与μ阿片受体互作在吗啡激动蛋白激酶C信号通路中的调控作用研究 国家自然科学基金 2012-01~2015-12 56万元 课题负责人
2011DFA33180 AMPA受体和M1受体协调调控机制及靶标药物研究 科技部国际科技合作项目 2012-01~2014-12 179万元 课题参与人
11PJ** FKBP12与μ阿片受体互作对吗啡激动蛋白激酶C信号通路的调控及其对吗啡镇痛耐受的影响 上海市科委—浦江人才 2011-10~2013-09 20万元 课题负责人
10ZR141700 脂筏影响μ阿片受体内吞和脱敏的分子机制 上海市科委-自然基金 2010-04~2012-03 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Lan-Xue Zhao, Mu-Wen Chen, Yue Qian, Qian-Hao Yang, Yan-Hui Ge, Hong-Zhuan Chen, Yu Qiu （通讯作者） M1 muscarinic receptor activation rescues β-amyloid-induced cognitive impairment through AMPA receptor GluA1 subunit Neuroscience 2019 408:239-247
Cai-Hong Xiong, Ming-Gang Liu, Lan-Xue Zhao, Mu-Wen Chen, Ling Tang, Ying- Hui Yan, Hong-Zhuan Chen, Yu Qiu （通讯作者） M1 muscarinic receptors facilitate hippocampus-dependent cognitive flexibility via modulating GluA2 subunit of AMPA receptors Neuropharmacology 2019 146: 242-251
Xu J, Tan P, Li H, Cui Y, Qiu Y, Wang H, Zhang X, Li J, Zhu L, Zhou W, Chen H. Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand-binding affinity and signal transduction FASEB J 2019 33(3):3237-3251
Lan-Xue Zhao, Yan-Hui Ge, Jia-Bing Li, Cai-Hong Xiong, Ping-Yee Law, Jian-Rong Xu, Yu Qiu （通讯作者）, Hong-Zhuan Chen M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt FASEB J 2019 33(5): 6622-6631
Lan-Xue Zhao, Yan-Hui Ge, Cai-Hong Xiong, Ling Tang, Ying-Hui Yan, Ping-Yee Law, Yu Qiu （通讯作者）, Hong-Zhuan Chen M1 muscarinic receptor facilitates cognitive function by interplay with AMPA receptor GluA1 subunit FASEB J 2018 32(8):4247-4257
Lan-Xue Zhao, Yan Wang, Ting Liu, Yan-Xia Wang, Hong-Zhuan Chen, Jian-Rong Xu,Yu Qiu （通讯作者） alpha-Mangostin decreases beta-amyloid peptides production via modulation of amyloidogenic pathway CNS Neurosci Ther 2017 23(6): 526-534
Shan Jiang, Ling Tang, Na Zhao, Wanling Yang, Yu Qiu （通讯作者）, Hong-Zhuan Chen A Systems View of the Differences between APOE ε4 Carriers and Non-carriers in Alzheimer's Disease Front Aging Neurosci 2016 8:171
Yan Wang, Yan-Hui Ge, Yan-Xia Wang, Ting Liu, Ping-Yee Law, Horace H. Loh, Hong-Zhuan Chen, Yu Qiu. （通讯作者） Modulation of mTOR activity by mu-opioid receptor is dependent upon the association of receptor and FK506-binding protein 12. CNS Neurosci Ther 2015 2015(7), 21:591-8
Shan Jiang, Wanling Yang, Yu Qiu （通讯作者）, Hong-Zhuan Chen, For The Alzheimer's Disease Neuroimaging Initiative ADNI Identification of Novel Quantitative Traits-Associated Susceptibility Loci for APOE ε 4 Non-Carriers of Alzheimer's Disease Curr Alzheimer Res 2015 12(3):218-27
Yan Wang, Yan-Xia Wang, Ting Liu, Ping-Yee Law, Horace H. Loh, Yu Qiu （通讯作者）, Hong-Zhuan Chen μ-Opioid Receptor Attenuates Aβ Oligomers-Induced Neurotoxicity Through mTOR Signaling CNS Neurosci Ther 2015 21:8-14
Zhuqin Hu, Fengxiang Yu, Ping Gong, Yu Qiu, Wei Zhou, Yongyao Cui, Juan Li, Hongzhuan Chen Subneurotoxic copper(II)-induced NF-κB-dependent microglial activation is associated with mitochondrial ROS Toxicol Appl Pharmacol 2014 276(2):95-103
Yu Qiu, Wei Zhao, Yan Wang, Jian-Rong Xu, Eddie Huie, Shan Jiang, Ying-Hui Yan, Horace H. Loh#, Hong-Zhuan Chen#, Ping-Yee Law K506 Binding Protein 12 Modulates mu Opioid Receptor Phosphorylation and PKCε-dependent Signaling by its Direct Interaction with the Receptor Mol Pharmacol 2014 85(1):37-49
Ying-Hui Yan, Yan Wang, Lan-Xue Zhao, Shan Jiang, Horace H. Loh, Ping-Yee Law, Hong-Zhuan Chen, Yu Qiu （通讯作者） Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization Neurosci lett 2014 566:231-5
Pan-Pan Tan, Hai-Hong Yuan, Xu Zhu, Yong-Yao Cui, Hui Li, Xue-Mei Feng, Yu Qiu, Hong-zhuan Chen, Wei Zhou Activation of Muscarinic Receptors Protects against Retinal Neurons Damage and Optic Nerve Degeneration In Vitro and In Vivo Models CNS Neurosci Ther 2014 20(3):227-36
Yan Wang, Zheng Xia, Jian-rong Xu, Yan-Xia Wang, Li-na Hou, Yu Qiu （通讯作者）, Hong-Zhuan Chen α-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation neuropharmacology 2012 62:871-881
Hong Qi, Wei Li, Yu Qiu （通讯作者）, Yong-yao Cui, Jian Ma, Xiao-ling Gao, Yi-bin Zeng, Jie Yang, Yun Tang, Xing-hai Wang, Wei Sheng, Qiong Xie, Jing-geng Liu, Zhui-bai Qiu, Hong-zhuan Chen Synthesis and evaluation of κ-opioid receptor agonistic activity and antinociceptive effect of novel morphine analogues, 7α-phenyl-6α, 14α-endo-etheno-tetrahydrothebaine with substituted o-, m- and p- amino group Med Chem Res 2011 20:1364-1370
Yu Qiu, Yan Wang, Ping-Yee Law, Hong-Zhuan Chen, and Horace H. Loh Cholesterol regulates μ-opioid receptor induced beta-arrestin 2 translocation to membrane lipid rafts Mol Pharmacol 2011 80(1):210-8
Jian Ma, Yu Qiu, Lan Yang, Liang Peng, Zheng Xia, Li-Na Hou, Cao Fang, Hong Qi, Hong-Zhuan Chen Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway J Neurooncol 2011 101(1):41-8
Xin Ge, Yu Qiu, Horace H. Loh and Ping-Yee Law Grin1 facilitates translocation of activated m opioid receptor into lipid raft to induce neurite outgrowth J Biol Chem 2009 284(52):36521-34
Lei Zhang, Hui Zhao,Yu Qiu, Horace H. Loh, Ping-Yee Law Src phosphorylation of mu-receptor is responsible for switching from an inhibitory to a stimulatory signal J Biol Chem 2009 284(4):1990-2000
Hui Zheng, Ji Chu, Yu Qiu, Horace H. Loh, and Ping-Yee Law α-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation Proc Natl Acad Sci U S A 2008 105(27):9421-6
Yu Qiu （通讯作者）, Horace H. Loh, and Ping-Yee Law Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization J Biol Chem 2007 282(31):22315-23