导师姓名： 徐璐 专业代码： 100700
性别： 女 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： luxupharm@163.com
邮编： 邮箱地址： luxuluxu@yahoo.com

研究方向 (点击浏览详细信息)
肿瘤药理

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** miR-483-3p调控上皮间质转化在非小细胞肺癌EGFR TKI获得性耐药和转移中的作用及机制 国家自然基金 2018-01~2021-12 55万元 课题负责人
** IGF1R信号通路在非小细胞肺癌EGFR TKI 耐药性产生中的作用及调控机制 国家自然基金 2014-01~2017-12 70万元 课题负责人
肺癌动物模型的建立和应用 上海市科委 2012-11~2014-09 40万元 课题负责人
12ZR** IGF1R信号通路在肺腺癌和肺腺癌干细胞对EGFR TKI靶向治疗耐药中的作用及机制 上海市科委 2012-07~2015-06 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Ling Li, Mengdi Hu,Tao Wang, Hongzhuan Chen*, Lu Xu* （通讯作者） Repositioning aspirin to treat lung and breast cancers and overcome acquired resistance to targeted therapy Frontiers in Oncology 2020 14;9:1503
Caiyun Wang, Tao Wang, Dacheng Lv, Ling Li, Jinnan Yue, Hongzhuan Chen*, Lu Xu* （通讯作者） Acquired resistance to EGFR TKIs mediated by TGF-b1/integrinb 3 signaling in EGFR-mutant lung cancer Molecular Cancer Therapeutics 2019 18(12):2357-2367
Yue J,Lv D,Wang C,Li L,Zhao Q, Chen H*, Xu L* （通讯作者） Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin b3 Oncogene 2018 37(31):4300-4312
Li L, Gu X, Yue J, Zhao Q, Lv D, Chen HZ*, Xu L* （通讯作者） Acquisition of EGFR TKI resistance and EMT phenotype is linked with activation of IGF1R/NF-κB pathway in EGFR-mutant NSCLC Oncotarget 2017 8(54): 92240-53
Zhang C, Ding XP, Zhao QN, Yang XJ, An SM, Wang H, Xu L* （通讯作者）, Zhu L*, Chen HZ* Role of a7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells. Oncotarget 2016 7(37): 59199-208
Zhao Q, Yue J, Zhang C, Gu X, Chen H*, Xu L* （通讯作者） Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC) Oncotarget 2015 6(30):29335-46
Zhao Q,Gu X,Zhang C,Lu Q,Chen H*,Xu L* （通讯作者） Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) Cancer Bio Ther 2015 16(4): 634-43
Xu L,Kikuchi E,Xu C,Ebi H,Ercan D,Cheng KA,Padera R, Engelman JA,J?nne PA,Shapiro GI,Shimamura T,Wong KK. Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET. Cancer Res 2012 72(13):3302-331
Xu L, Sterling CR, Tank AW cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3’ untranslated region and poly(C)-binding protein 2. Mol Pharmacol 2009 76(4):872-883
Chen X*, Xu L* （共同第一作者）, Radcliffe P, Sun B, Tank AW. Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. 73(6): 1816-1828. Mol Pharmacol 2008 73(6):1816-1828
Xu L, Chen X, Sun B, Sterling C, Tank AW. Evidence for regulation of tyrosine hydroxylase mRNA translation by stress in rat adrenal medulla. Brain Res 2007 1158():1-10
Sun B, Chen X, Xu L, Sterling C, Tank AW.66(4): 1011-1021. Chronic nicotine treatment leads to induction of tyrosine hydroxylase in locus ceruleus neurons: the role of transcriptional activation. Mol Pharmacol 2004 66(4):1011-1021