导师姓名： 宋明柯 专业代码： 100700
性别： 男 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： mksong@sjtu.edu.cn —— 读书和接受教育使我们懂得如何做选择和面对挑战，要在对社会和人生有意义的事情上培养兴趣、树立信心，然后在这个职业道路上保持耐心、努力坚持，相信你会抓住机遇和获得满满的回报。选择学医，也就选择了一份造福人民健康的事业。千里之行，始于足下，你我的健康事业从第一门医学专业课程开始，从第一项医学研究课题开始。欢迎新同学来到我的课题组！
邮编： 200025 邮箱地址： mk_song@hotmail.com

研究方向 (点击浏览详细信息)
神经退行性疾病的分子药理学和神经再生研究

社会任职
美国神经科学学会会员, 2009-2014
美国心脏协会会员, 2012-2015
中国生物化学与分子生物学会会员，2017年起
美国埃默里大学第二届科研论文写作研讨会评委（2014）
美国埃默里大学DSAC学生研究论坛特邀评委，2012-2015

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 应用活体成像技术研发... 国家自然科学基金 —— 重大研究计划（培育项目） 2020-01~2022-12 68万元 课题负责人
** 光遗传学刺激促进iPSC神经分化和移植后的功能性整合研究 国家自然科学基金 2019-01~2022-12 56万元 课题负责人
** 阿尔茨海默病新型体液生物标志物的发现和研究 国家自然科学基金 2017-01~2020-12 57万元 课题负责人
12POST** Optogenetic stimulation of the SVZ combined with administration of BMSCs to repair ischemia-damaged neuronal circuits 美国心脏协会（American Heart Association） 2012-06~2014-06 65万元 课题负责人
** 胆碱系统对气道上皮-间质转化的作用及其信号调控研究 国家自然科学基金 2011-01~2013-12 33万元 课题参与人
** 分子伴侣AChE诱导Aβ寡聚体形成的动力学和膜离子通道改变的研究 国家自然科学基金 2010-01~2012-12 32万元 课题参与人
** 新型选择性K+通道阻滞剂Talatisamine对Kv2.1亚型的调制作用及机制 国家自然科学基金 2010-01~2012-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Mingke Song （通讯作者） Psychological Stress Responses to COVID-19 and Adaptive Strategies in China World Development 2020 (136),105107
Hu HJ, Wang SS, Wang YX, Liu Y, Feng XM, Shen Y, Zhu L, Chen HZ, Song M （通讯作者） Blockade of the forward Na+/Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+‐mediated cell death British Journal of Pharmacology 2019 2019 Aug;176(15):2691-2707
Ping Yu S, Tung JK, Wei ZZ, Chen D, Berglund K, Zhong W, Zhang JY, Gu X, Song M, et al. Optochemogenetics Stimulation of Transplanted iPS-NPCs Enhances Neuronal Repair and Functional Recovery after Ischemic Stroke J Neurosci 2019 doi: 10.1523/JNEUROSCI.2010-18.2019
Zhang Z, Li XG, Wang ZH, Song M, et al. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Mol Psychiatry 2018 doi: 10.1038/s41380-018-0286-z
Hui-Jie Hu, Mingke Song （通讯作者） Disrupted Ionic Homeostasis in Ischemic Stroke and New Therapeutic Targets Journal of Stroke and Cerebrovascular Diseases 2017 26(12) 2706-2719
Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M,et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease Nat Commun 2017 doi: 10.1038/ncomms14740
Song Mingke, Yu SP, Mohamad O, et al. Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice. Neurobiology of Disease. 2017 2017 Feb;98:9-24
Ban K, Wile B, Cho KW, Kim S, Song MK, et al. Non-genetic Purification of Ventricular Cardiomyocytes from Differentiating Embryonic Stem Cells through Molecular Beacons Targeting IRX-4. Stem Cell Reports 2015 Dec 8;5(6):1239-1249
Zhang Z, Song Mingke, Liu X, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease Nature Communications. 2015 2015 Nov 9; 6:8762.
Zhang Z, Song Mingke, Liu X, et al. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. Nature Medicine 2014 2014; 20(11):1254-62
Chau M, Deveau TC, Song M, Gu X, Chen D, Wei L iPS Cell Transplantation Increases Regeneration and Functional Recovery after Ischemic Stroke in Neonatal Rats Stem Cells 2014 Dec;32(12):3075-87.
Mohamad O, Yu SP, Chen D, Ogle M, Song M, Wei L. Efficient neuronal differentiation of mouse ES and iPS cells using a rotary cell culture protocol. Differentiation. 2014 Jan 27. pii: S0301-4681(13)00084-4.
Song M, Yu SP. Ionic regulation of cell volume changes and cell death after ischemic stroke Translational Stroke Research 2014 Feb;5(1):17-27
Zhang Z, Liu X, Schroeder JP, Chan CB, Song M,et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease Neuropsychopharmacology 2014 Feb;39(3):638-50
Song Mingke, Chen D, Yu SP. The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na+/Ca2+ exchanger and increasing intracellular Ca2+ British Journal of Pharmacology. 2014 2014 Jul;171(14):3432-3447
Chen D, Song M, Mohamad O, Yu SP. Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells. BMC Cancer 2014 Sep 26;14:716
Song M, Mohamad O, Gu X, Wei L, Yu SP Restoration of intracortical and thalamocortical circuits after transplantation of bone marrow mesenchymal stem cells into the ischemic brain of mice. Cell Transplantation 2013 22(11):2001-15
Song M, Mohamad O, Chen D, Yu SP Coordinated development of voltage-gated Na+ and K+ currents regulates functional maturation of forebrain neurons derived from human induced pluripotent stem cells. Stem Cells Dev 2013 May 15;22(10):1551-63
Mingke Song, Anna Woodbury, Shan Ping Yu White Matter Injury and Potential Treatment in Ischemic Stroke Book chapter. Springer-Verlag New York 2013 Volume 4, pp 39-52
Mohamad O, Song M （共同第一作者）, Wei L, Yu SP. Regulatory roles of the NMDA receptor GluN3A subunit in locomotion, pain perception and cognitive functions in adult mice. The Journal of physiology 2013 Jan 1;591(1):149-68
Mohamad O, Drury-Stewart D, Song M, et al. Vector-Free and Transgene-Free Human iPS Cells Differentiate into Functional Neurons and Enhance Functional Recovery after Ischemic Stroke in Mice PLoS One 2013 May 23;8(5):e64160
Drury-Stewart D, Song M, Mohamad O, et al Highly efficient differentiation of neural precursors from human embryonic stem cells and benefits of transplantation after ischemic stroke in mice Stem Cell Research & Therapy 2013 Aug 8;4(4):93
Xu Q, Huang S, Song M, Wang CE,et al. Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms The Journal of cell biology 2013 Sep 30;202(7):1123-38
Wang Y, Song M （共同第一作者）, Hou L, Yu Z, Chen H The newly identified K+ channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons Neuroscience Letters 2012 Jun 19;518(2):122-7
Hong Y, Chan CB, Kwon IS, Li X, Song M,et al. SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease The Journal of Neuroscience 2012 Nov 28; 32(48):17262-72
Zhou X, Wei J, Song M, Francis K, Yu SP. Novel role of KCNQ2/3 channels in regulating neuronal cell viability. Cell Death & Differentiation 2011 Mar;18(3):493-505.
Zhou X, Song M, Chen D, Wei L, Yu SP. Potential role of KCNQ/M-channels in regulating neuronal differentiation in mouse hippocampal and embryonic stem cell-derived neuronal cultures. Experimental Neurology 2011 Jun;229(2):471-83
Li J, Li Y, Ogle M, Zhou X, Song M, Yu SP, and Wei L DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway Brain Res 2010 Nov 4;1359: 216-26
Song MK, Cui YY, Zhang WW, et al The facilitating effect of systemic administration of Kv7/M channel blocker XE991 on LTP induction in the hippocampal CA1 area independent of muscarinic activation Neuroscience Letters 2009 Sep 11;461(1):25-9
Zhang WW, Song MK （共同第一作者）, Cui YY, et al. Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine Neuroscience Letters 2008 Oct 10;443(3):241-5
Song MK, Liu H, Jiang HL, Yue JM, Hu GY, Chen HZ. Discovery of talatisamine as a novel specific blocker for the delayed rectifier K+ channels in rat hippocampal neurons Neuroscience 2008 ug 13;155(2):469-75
Song MK, Liu H, Jiang HL, Yue JM, Hu GY Electrophysiological characterization of 14-benzoyltalatisamine, a selective blocker of the delayed rectifier K+ channel found in virtual screening. European Journal of Pharmacology 2006 Feb 15;531(1-3):47-53
Liu H, Li Y, Song MK （共同第一作者）, Tan X, Cheng F, et al Structure-based discovery of potassium channel blockers from natural products: virtual screening and electrophysiological assay testing Chemistry & Biology. 2003 Nov;10(11):1103-13
Song GL(曾用名), Tang M, Liu CJ, et al. Developmental changes in functional expression and beta-adrenergic regulation of I(f) in the heart of mouse embryo Cell Research 2002 Dec;12(5-6):385-94.