导师姓名： 王昊 专业代码： 100700
性别： 女 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海交通大学医学院药理学与化学生物学系
邮编： 200025 邮箱地址： angela_wanghao@hotmail.com

研究方向 (点击浏览详细信息)
抗阿尔茨海默病胆碱能创新靶点和创新药物的研究

社会任职
上海市青年联合会第十届委员会委员
上海市药学会第十一届理事会药理学专业委员会委员
上海市黄浦区妇女联合会第二届执行委员会委员
上海交通大学女教师女医生学术交流协会副会长
上海交通大学医学院少数民族联合会常务副会长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** α7烟碱型乙酰胆碱受体介导的中枢抗炎通路的转录后调节新机制 国家自然科学基金 2020-01~2023-12 55万元 课题负责人
19JC** 基于HDX-MS技术的M1胆碱受体与Gαq/11蛋白偶联障碍的分子机制研究 上海市“科技创新行动计划”基础研究领域重点项目 2019-11~2022-10 78万元 课题负责人
** M1受体选择性激活和Gαq-PKC信号偏好的变构新位点发掘及调控机制 国家自然科学基金 2019-01~2022-12 60万元 课题参与人
ZH2018ZDA23 抗老年痴呆中药有效成分的大数据挖掘及多靶点活性的药理学研究 上海交通大学“医学转化交叉基金” 2019-01~2021-12 50万元 课题负责人
ZH2018ZDA23 抗老年痴呆中药有效成分的大数据挖掘及多靶点活性的药理学研究 上海交通大学“转化医学交叉研究基金”重点项目 2019-01~2021-12 50万元 课题负责人
** 乙酰胆碱酯酶新基序AChE7-20非酶活性依赖的海马神经元毒性调控机制 国家自然科学基金 2016-01~2019-12 86.4万元 课题参与人
** 多靶点抗阿尔茨海默病创新药物XQ509的临床前研究 上海市科委“科技创新行动计划”生物医药领域科技支撑项目 2014-07~2017-09 50万元 课题负责人
** 基于MT7生物毒素的M1受体高选择性先导物的改造及其药理活性研究 国家自然科学基金 2014-01~2017-12 65万元 课题负责人
新型多靶点抗老年性痴呆候选化合物(-)-苯氨甲酸美普他酚酯的成药性研究 上海市科委生物医药重点科技攻关项目 2010-07~2013-09 30万元 课题负责人
2010CB529806 重要药用前景动物多肽毒素的临床应用基础研究 国家重点基础研究（973计划）课题 2010-01~2014-12 247万元 课题参与人
2009ZX09103-077 具有多靶点作用抗老年性痴呆候选药物XQ509的研究 科技部 2009-01~2010-12 150万元 课题参与人
08QA** 具有AChE和AB双重抑制作用的AChEI的化学生物学研究 上海市科委启明星 2008-07~2010-07 15万元 课题负责人
** 胃食管反流性气道神经源性炎症中M胆碱受体及其亚型介导机制 国家自然基金委面上项目 2007-01~2009-12 21万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chen LK, Zhang SF, Tian WT, Huang LL, Jiang XL, Chen XM, Wang H （通讯作者）, Su DS Cerebral spinal fluid cholinergic biomarkers predict postoperative cognitive dysfunction in aged patients – A prospective, observational, single center study Journal of Clinical Anesthesia 2020 109743
He Xuan, Yang Shuangshuang, Zhang Rui, Hou Lina, Xu Jianrong, Hu Yaer, Xu Rang, Wang Hao （通讯作者）, Zhang Yongfang Smilagenin protects dopaminergic neurons in chronic MPTP/probenecid-lesioned Parkinson’s Disease models Frontiers in Cellular Neuroscience 2019 13:18
Wang Yu, Xia Jia, Shen Mengjun, Zhou Yifan, Wu Zhe, Shi Yuhuan, Xu Jianrong, Hou Lina, Zhang Rui, Qiu Zhuibai, Xie Qiong, Chen Hongzhuan, Zhang Yongfang, Wang Hao （通讯作者） Effects of BIS-MEP on reversing amyloid plaque deposition and spatial learning and memory impairments in a mouse model of β-amyloid peptide- and ibotenic acid-induced Alzheimer's disease Frontiers in Aging Neuroscience 2019 11:3
Hu YB, Zhang YF, Wang H （通讯作者）, Ren RJ, Cui HL, Huang WY, Cheng Q, Chen HZ, Wang G. miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson’s disease Cell Death Dis 2019 10(8):589
Xu J, Tan P, Li H, Cui Y, Qiu Y, Wang H, Zhang X, Li J, Zhu L, Zhou W, Chen H Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand-binding affinity and signal transduction FASEB J 2019 33(3):3237-3251
Hu YB, Ren RJ, Zhang YF, Huang Y, Cui HL, Ma C, Qiu WY, Wang H, Cui P, Chen HZ, Wang G. Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology Aging Cell 2019 e13001. doi: 10.1111/acel.13001. [Epub ahead of print]
Hu YB, Ren RJ, Zhang YF, Huang Y, Cui HL, Ma C, Qiu WY, Wang H （通讯作者）, Cui PJ, Chen HZ, Wang G Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology Aging Cell 2019 9:e13001
Shi Yuhuan, Huang Wanying, Wang Yu, Zhang Rui, Hou Lina, Xu Jianrong, Qiu Zhuibai, Xie Qiong, Chen Hongzhuan, Zhang Yongfang, Wang Hao （通讯作者） Bis(9)-(-)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice Translational Neurodegeneration 2018 7:21
Wang Ling, Wang Yu, Tian Yiguang, Shang Jinling, Sun Xiaoou, Chen Hongzhuan, Wang Hao （通讯作者）, Tan Wen Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors Bioorganic & Medicinal Chemistry 2017 25(1): 360-371
Xie Qiong, Zheng Zhaoxi, Shao Biyun, Fu Wei, Xia Zheng, Li Wei, Sun Jian, Zheng Wei, Zhang Weiwei, Sheng Wei, Zhang Qihong, Chen Hongzhuan, Wang Hao （通讯作者）, Qiu Zhuibai Pharmacophore-based design and discovery of (-)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis Journal of Enzyme Inhibition and Medicinal Chemistry 2017 32(1): 659-671
Wang Yu, Wang Hao （通讯作者）, Chen Hongzhuan. AChE inhibition-based multi-target-directed ligands, a novel pharmacological approach for the symptomatic and disease-modifying therapy of Alzheimer's disease Current Neuropharmacology 2016 14(4):364~475
Cui L, Wang Y, Liu Z, Chen H, Wang H （通讯作者）, Zhou X, Xu J. Discovering New Acetylcholinesterase Inhibitors by Mining the Buzhongyiqi Decoction Recipe Data J Chem Inf Model 2015 55(11):2455-63
Xu J, Zhao H, Zheng Z, Wang Y, Niu Y, Wang H （通讯作者）, Xu J, Lu Y, Chen H. Structural determinants for the interactions between muscarinic toxin 7 and muscarinic acetylcholine receptors. J Mol Recognit 2015 28(4):239-52
Zheng Z, Tang Y, Lv H, Xu J, Zhao H, Xie Q, Qiu Z, Chen H, Wang H. Determination of Meserine, a new candidate for Alzheimer's disease in mice brain by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic and tissue distribution study Anal Bioanal Chem 2014 406(14):3451-8
Shao BY, Xia Z, Xie Q, Ge XX, Zhang WW, Sun J, Jiang P, Wang H, Le WD, Qiu ZB, Lu Y, Chen HZ. Meserine, a novel carbamate AChE inhibitor, ameliorates scopolamine-induced dementia and alleviates amyloidogenesis of APP/PS1 transgenic mice. CNS Neurosci Ther 2014 20(2):165-71
Hou LN, Xu JR, Zhao QN, Gao XL, Cui YY, Xu J, Wang H （通讯作者）, Chen HZ. A new motif in the N-terminal of acetylcholinesterase triggers amyloid-β aggregation and deposition CNS Neurosci Ther 2014 20(1):59-66
Xie Y, Jiang P, Ge X, Wang H （通讯作者）, Shao B, Xie Q, Qiu Z, Chen H. Determination of a novel carbamate AChE inhibitor meserine in mouse plasma, brain and rat plasma by LC-MS/MS: Application to pharmacokinetic study after intravenous and subcutaneous administration J Pharm Biomed Anal 2014 96C:156-61
Liu T, Xia Z, Zhang WW, Xu JR, Ge XX, Li J, Cui Y, Qiu ZB, Xu J, Xie Q, Wang H （通讯作者）, Chen HZ. Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice Pharmacol Biochem Behav 2013 104:138-43
Liu Y, Wang H （共同第一作者）, Cheng Y, Sun J, Qian J, Lu H, Zhu L, Gong L, Ren J. A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats Drug Chem Toxicol 2013 36(4): 443-50
Xu JR, Wang H, Chen HZ. Muscarinic acetylcholine receptor modulators derived from natural toxins and diverse Science China Chemistry 2013 56 (10): 1333-43
Ge XX, Wang XL, Jiang P, Xie Y, Jiang T, Rong ZX, Zhang QZ, Xie Q, Qiu ZB, Wang H （通讯作者）, Chen HZ. Determination of Bis(9)-(-)-Meptazinol, a bis-ligand for Alzheimer's disease, in rat plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics study J Chromatogr B Analyt Technol Biomed Life Sci 2012 881-882:126-30
Wang H, Chen XY, Wang BS, Rong ZX, Qi H, Chen HZ. The efficacy and safety of arsenic trioxide with or without all-trans retinoic acid for the treatment of acute promyelocytic leukemia: a meta-analysis Leuk Res 2011 35(9):1170-7
Song YY, Wang H （共同第一作者）, Wang BS, Qi H, Rong ZX, Chen HZ. Atropine in ameliorating the progression of myopia in children with mild to moderate myopia: a meta-analysis of controlled clinical trials J Ocul Pharmacol Ther 2011 27(4):361-8
Xu ZP, Wang H （共同第一作者）, Hou LN, Xia Z, Zhu L, Chen HZ, Cui YY. Modulatory effect of anisodamine on airway hyper-reactivity and eosinophilic inflammation in a murine model of allergic asthma Int Immunopharmacol 2011 11(2):260-5
Wang BS, Wang H （共同第一作者）, Song YY, Qi H, Rong ZX, Wang BS, Zhang L, Chen HZ. Effectiveness of standardized ginkgo biloba extract on cognitive symptoms of dementia with a six-month treatment: a bivariate random effect meta-analysis Pharmacopsychiatry. 2010 43(3):86-91.
Wei ZH, Wang H （共同第一作者）, Chen XY, Wang BS, Rong ZX, Wang BS, Su BH, Chen HZ. Time and dose dependent effect of psyllium on serum lipids in mild to moderate hypercholesterolemia: a meta-analysis of controlled clinical trials Eur J Clin Nutr. 2009 63(7):821-7.
Wang H, Boissel JP, Nony P. Revisiting the relationship between baseline risk and risk under treatment Emerg Themes Epidemiol. 2009 6:1-4
Wang BS, Wang H （共同第一作者）, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis J Neural Transm. 2009 116(4):457-65.
Wang H, Qi H, Wang BS, Cui YY, Zhu L, Rong ZX, Chen HZ. Is acupuncture beneficial in depression: A meta-analysis of 8 randomized controlled trials? J Affect Disord J Affect Disord. 2008 111(2-3):125-34.
Xie Q, Wang H （共同第一作者）, Xia Z, Lu MY, Zhang WW, Wang XH, Fu W, Sheng W, Li W, Zhou W, Zhu X, Qiu ZB, Chen HZ. Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on Amyloid-β aggregation J Med Chem. 2008 51(7):2027-36.
Wang H, Wu XJ, Cui YY, Zhu L, Lu Y, Chen HZ. Up-regulation of M1 muscarinic receptors expressed in CHOm1 cells by panaxynol via cAMP pathway Neurosci Lett. 2005 383(1-2):121-6.
Wang H （共同第一作者）, Lu Y, Chen HZ. Differentiating effects of anisodamine on cognitive amelioration and peripheral muscarinic side effects induced by pilocarpine in mice Neurosci Lett. 2003 344(3):173-6.
Wang H （共同第一作者）,Guo ZD, Li Z. Effects of various muscarinic ligands on M2-Gia fusion protein expressed SF9 insect cells Acta Pharmacol Sin. 2002 23:230-6