导师姓名： 周虎臣 专业代码： 100700
性别： 女 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： hczhou@sjtu.edu.cn
邮编： 200240 邮箱地址： hczhou@sjtu.edu.cn

研究方向 (点击浏览详细信息)
生物有机化学；化学生物学

社会任职
J. Med. Chem., Eur. J. Med. Chem., MedChemComm, BMC, BMCL, FEBS Letter审稿人
中国药学会药物化学专业委员会委员
美国化学会(ACS) 会员
中国化学会会员
上海高校E-化学生物学研究院特聘研究员
上海药学会药物化学专业委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** SENPs选择性抑制剂的设计、合成、以及抗肿瘤活性研究 国家自然科学基金面上项目 2016-01~2019-12 71.4万元 课题负责人
** 药物化学和化学生物学 国家自然科学基金优秀青年基金 2013-01~2015-12 100万元 课题负责人
2012CB518000 重大心血管疾病相关GPCR新药物靶点的基础研究 国家重大科学研究计划 2012-01~2016-12 30万元 课题参与人
YG2009MS01 利用小分子化合物SSMU11研究RARa降解的分子机制 医工（理）交叉研究基金 2009-06~2011-06 5万元 课题参与人
2009CB918404 蛋白质翻译后修饰的发生与调控机制及其生理病理效应 重大科学研究计划973 2009-01~2013-12 40万元 课题参与人
07SG15 蛋白质-蛋白质间相互作用的小分子干扰剂的设计与合成 上海教委曙光**** 2008-01~2009-12 15万元 主要责任人
** 疟疾和血吸虫病的新药设计,合成及构效关系 自然科学基金 2008-01~2010-12 20万元 主要责任人
07pj14095 锥虫病和血吸虫病治疗新药物的设计,合成及构效关系 上海科委浦江计划 2007-09~2009-09 20万元 主要责任人
抗感染药物的药物化学研究和计算机辅助药物设计 横向国际合作 2007-04~2010-03 120万元 主要责任人

学术论文 作者论文标题期刊名出版年卷期页码
G. Gao, Y. Yao, K. Li, D. Mashausi, D. Li, H. Negi, S. Kamle, H. Chen, Z. Wu, H. Zhou （通讯作者）, D. Li A human leucyl-tRNA synthetase as an anticancer target OncoTargets Ther. 2015 8: 2933-2942.
Y. Zhao, Q. Meng, L. Bai, H. Zhou （通讯作者） In silico discovery of aminoacyl-tRNA synthetase inhibitors Int. J. Mol. Sci. 2014 15: 1358-1373.
P. Wu, J. Zhang, Q. Meng, B. Nare, R.T. Jacobs, H. Zhou （通讯作者） Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei Eur. J. Med. Chem. 2014 81: 59-75.
Q. Hu, R. Liu, Z. Fang, J. Zhang, Y. Ding, M. Tan, M. Wang, W. Pan, H. Zhou （通讯作者）, E. Wang Discovery of a potent benzoxaborole-based anti-pneumococcal agent Sci. Rep. 2013 3: 2475.
A. Friesland, Y. Zhao, Y. Chen, L. Wang, H. Zhou （通讯作者）, Q. Lu A small molecule targeting cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility Proc. Natl. Acad. Sci. 2013 110: 1261-1266.
Q. Yin, C. Liu, Y. Wu, S. Wu, Y. Wang, X. Zhang, X. Hu, J. Pu, Y. Lu, H. Zhou, H. Wang, H. Nie, H. Sun, G. Chen Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-kB signaling J. Immunol. 2013 191: 2115-2125.
C. Liu, H. Zhou, Q. Yin, Y. Wu, G. Chen Targeting peroxiredoxins against leukemia Exp. Cell Res. 2013 319: 170-176.
Y. Zhao, F. Zhou, H. Zhou （通讯作者）, H. Su The structural and bonding evolution in cysteine-gold cluster compleses Phys. Chem. Chem. Phys. 2013 15: 1690-1698.
J. Zhang, M. Zhu, Y. Lin, H. Zhou （通讯作者） The synthesis of benzoxaboroles and their applications in medicinal chemistry Sci. China Chem. 2013 56: 1372-1381.
F. Zhang, J. Du, Q. Wang, Q. Hu, J. Zhang, D. Ding, Y. Zhao, F. Yang, E. Wang, H. Zhou （通讯作者） Discovery of N-(4-sulfamoylphenyl)thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors Org. Biomol. Chem. 2013 11: 5310-5324.
H. He, D. Liao, Z. Wang, Z. Wang, H. Zhou, M. Wang, R. Ye Functional characterization of three mouse formyl peptide receptors Mol. Pharmacol. 2013 83: 389-398.
J. Zhang, H. Zhou （通讯作者） The application of small molecule bioactive probes in the identification of cellular targets. Yaoxue Xuebao 2012 47(1):299-306.
Y. Zhang, J. Plattner, Y. Freund, E. Easom, Y. Zhou, L. Ye, H. Zhou, D. Waterson, F. Gamo, L. Sanz, M. Ge, Z. Li, L. Li, H. Wang, H. Cui Benzoxaborole antimalarial agents. 2. Discovery of fluoro-substituted 7-(2-carbozyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles. Bioorg. Med. Chem. Lett. 2012 22(1):1299-1307.
C. Liu, Q. Yin, H. Zhou （共同第一作者）, Y. Wu, J. Pu, L. Xia, W. Liu, X. Huang, T. Jiang, M. Wu, L. He, Y. Zhao, X. Wang, W. Xiao, H. Chen, Q. Zhao, A. Zhou, L. Wang, H. Sun, G. Chen Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nature Chem. Biol. 2012 8(1):486-493.
Z. Qiao, Q. Wang, F. Zhang, Z. Wang, T. Bowling, B. Nare, R. Jacobs, J. Zhang, D. Ding, Y. Liu, H. Zhou （通讯作者） Chalcone-benzoxaborole hybrid molecules as potent antitrypanosomal agents. J. Med. Chem. 2012 55(1):3553-3557.
Y. Zhao, Q. Wang, Q. Meng, D. Ding, H. Yang, G. Gao, D. Li, W. Zhu, H. Zhou （通讯作者） Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis. Bioorg. Med. Chem. 2012 20(1):1240-1250.
D. Ding, Q. Meng, G. Gao, Y. Zhao, Q. Wang, B. Nare, R. Jacobs, F. Rock, M. Alley, J. Plattner, G. Chen, D. Li, H. Zhou （通讯作者） Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents. J. Med. Chem. 2011 54(1):1276-1287.
Z. Qiao, W. Wang, L. Wang, D. Wen, Y. Zhao, Q. Wang, Q. Meng, G. Chen, Y. Wu, H. Zhou （通讯作者） Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors. Bioorg. Med. Chem. Lett. 2011 21(1):6389-6392.
Z. Gu, C. Liu, S. Wu, M. Zhao, H. Xu, W. Liu, H. Zhou, G. Chen, Y. Wu PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells. FEBS Lett. 2011 585(1):375-380.
M. Wu, Q. Meng, M. Ge, L. Bai, H. Zhou （通讯作者） 2,3,6-Trideoxy sugar nucleotides: synthesis and stability. Tetrahedron Lett. 2011 52(1):5799-5801.
P. Wu, Q. Meng, H. Zhou （通讯作者） Synthesis of novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride. Chin. Chem. Lett. 2011 22(1):1411-1414.
D. Ding, Y. Zhao, Q. Meng, D. Xie, B. Nare, D. Chen, C. Bacchi, N. Yarlett, Y. K. Zhang, V. Hernandez, Y. Xia, Y. Freund, M. Abdulla, K. H. Ang, J. Ratnam, J. H. McKerrow, R. T. Jacobs, H. Zhou （通讯作者）, J. J. Plattner Discovery of novel benzoxaborole-based potent antitrypanosomal agents. ACS Med. Chem. Lett. 2010 1, 165-169.
Y. Wu, H. Zhou, G. Chen Molecular mechanisms of leukemia-associated protein degradation. Front. Med. China 2010 4(1):363-370.
W. Chen, T. Huang, X. He, Q. Meng, D. You, L. Bai, J. Li, M. Wu, R. Li, Z. Xie, H. Zhou, X. Zhou, H. Tan, Z. Deng Charaterization of the polyoxin biosynthesis gene cluster from Streptomyces cacaoi and engineered production of polyoxin H. J. Biol. Chem. 2009 284, 10627-10638.
L. Ye, D. Ding, Y. Feng, D. Xie, P. Wu, H. Guo, Q. Meng, H. Zhou （通讯作者） Convenient and versatile synthesis of formyl-substituted benzoxaboroles. Tetrahedron 2009 65, 8738-8744
T. Akama, S. J. Baker, Y. K. Zhang, V. Hernandez, H. Zhou, V. Sanders, Y. Freund, R. Kimura, K. R. Maples, J. J. Plattner Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg. Med. Chem. Lett. 2009 19, 2129-2132.
Q. Lu, F. M. Longo, H. Zhou, S. M. Massa, Y. Chen Signaling through Rho GTPase pathway as viable drug target. Curr. Med. Chem. 2009 16, 1355-1365.
Y. Zhou, Q. Meng, D. You, J. Li, S. Chen, D. Ding, X. Zhou, H. Zhou （通讯作者）, L. Bai, Z. Deng Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in streptomyces sp. strain FR-008. Appl. Environ. Microbiol. 2008 74, 7235-7242.
F. L. Rock, W. Mao, A. Yaremchuk, M. Tukalo, T. Crepin, H. Zhou, Y. K. Zhang, V. Hernandez, T. Akama, S. J. Baker, J. J. Plattner, L. Shapiro, S. A. Martinis, S. J. Benkovic, S. Cusack, M. R. K. Alley An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science 2007 316, 1759-1761.
H. Zhou, L. Baldini, J. Hong, A. Wilson, A. D. Hamilton Pattern-recognition of proteins based on an array of functionalized porphyrins J. Am. Chem. Soc. 2006 128, 2421-2425.
H. Zhou, L. Baldini, E. Ennis, R. Jain, S. M. Sebti, D. A. Wang, M. A. Blaskovich, A. D. Hamilton Structure-Activity studies of a library of potent calix[4]arene based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation Org. Biomol. Chem. 2006 4, 2376-2386.
S. J. Baker, Y. K. Zhang, T. Akama, A. Lau, H. Zhou, V. Hernandez, W. Mao, M. R. K. Alley, V. Sanders, J. J. Plattner Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis. J. Med. Chem. 2006 49, 4447-4450.