导师姓名： 肖泽宇 专业代码： 100700
性别： 女 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： (021)** ext.776415
邮编： 邮箱地址： xiaozeyu@shsmu.edu.cn

研究方向 (点击浏览详细信息)
纳米医学与生物工程

社会任职
美中医药协会会员
美国癌症研究协会会员
中国化学会会员
Bridge Medicine 编辑
美国化学会会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2020YFA** 多模块可编程纳米药物的活体动态可视化研究 国家重点研发计划 2020-11~2025-10 212万元 课题负责人
2020 新型冠状病毒核酸现场快速检测设备及试剂的研发 国家重点研发计划 2020-02~2020-04 100万元 课题参与人
2020 家庭简易式新型冠状病毒感染自查技术与试剂盒 上海交通大学医工交叉研究基金重点项目 2020-02~2021-01 100万元 课题参与人
** 拉曼纳米探针用于活性氧异常疾病的医学分析研究 国家自然科学基金 2019-01~2022-12 64万元 课题负责人
** SP-A核酸适体拉曼纳米探针用于胎肺发育及异常的产前诊断研究 国家自然科学基金 2018-01~2018-12 20万元 课题负责人
** 核酸识体纳米药物在组织脏器的三维精准分布及靶向识别 国家自然科学基金 2017-01~2020-12 62万元 课题负责人
** DNA自主装纳米诊疗系统：构建及术中成像介导下前列腺癌细胞清除的问题研究 国家自然科学基金 2015-01~2018-12 73万元 课题负责人
2014 上海市高层次人才计划 上海市教委 2015-01~2017-12 100万元 课题负责人
2014 国家高层次青年人才计划 中组部 2015-01~2017-12 200万元 课题负责人
2014 课题启动经费 上海交大医学院 2014-08~2019-12 200万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Gao S, Wei G, Zhang S, Zheng B, Xu J, Chen G, Li M, Song S, Fu W, Xiao Z* （通讯作者）, Lu W* Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics. Nat Commun. 2019 10(1):2206
Gu X, Qiu Y, Lin M, Cui K, Chen G, Chen Y, Fan C, Zhang Y, Xu L, Chen H, Wan JB, Lu W, Xiao Z* （通讯作者） CuS Nanoparticles as a Photodynamic Nanoswitch for Abrogating Bypass Signaling To Overcome Gefitinib Resistance. Nano Lett. 2019 19(5):3344-3352
Xu J, Yu S, Wang X, Qian Y, Wu W, Zhang S, Zheng B, Wei G, Gao S, Cao Z, Fu W, Xiao Z* （通讯作者）,Lu W* High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy. ACS Nano 2019 13,10242-10260
Qiu Y, Lin M, Chen G, Fan C, Li M, Gu X, Cong S, Zhao Z, Fu L, Fang X, Xiao Z* （通讯作者） Photodegradabl CuS SERS probes for intraoperative residual tumor detection, ablation and self-clearance. ACS Appl Mater Interfaces 2019 11(26):23436-23444
Zheng B, Xu J, Chen G, Zhang S, Xiao Z* （通讯作者）, Lu W* Bacterium-Mimicking Vector with Enhanced Adjuvanticity for Cancer Immunotherapy and Minimized Toxicity. Adv. Func. Mater. 2019 29(33),**
Wu W, Xiao Z* （通讯作者） A deep learning “ticket” for single-molecule analysis of protein stoichiometry Sci China Chem 2019 62，1269-1270
Qiu Y, Zhang Y, Li M, Chen G, Fan C, Cui K, Wan J, Han A, Ye J*, Xiao Z* （通讯作者） Intraoperative detection and eradication of residual microtumors with gap-enhanced Raman tags. ACS Nano 2018 12(8):7974-7985
Cui K, Fan C, Chen G, Qiu Y, Li M, Lin M, Wan JB, Cai C, Xiao Z* （通讯作者） para-Aminothiophenol Radical Reaction-Functionalized Gold Nanoprobe for One-to-All Detection of Five Reactive Oxygen Species in Vivo. Anal Chem 2018 90, 12137-12144
Li M, Qiu Y, Fan C, Cui K, Zhang Y, Xiao Z* （通讯作者） Design of SERS nanoprobes for Raman imaging: materials, critical factors and architectures. Acta Pharm Sin B. 2018 8(3):381-389
Zhang Y, Qiu Y, Lin L, Gu H, Xiao Z* （通讯作者）, Ye J* Ultraphotostable Mesoporous Silica-Coated Gap-Enhanced Raman Tags (GERTs) for High-Speed Bioimaging. ACS Appl Mater Interfaces 2017 9(4):3995-4005
Qi Q, Lu L, Li H, Yuan Z, Chen GX, Lin M, Ruan Z, Ye X*, Xiao Z* （通讯作者）, Zhao Q* Spatiotemporal delivery of nanoformulated liraglutide for cardiac regeneration after myocardial infarction. Int J Nanomedicine 2017 12:4835-4848
Lu L, Chen G, Qiu Y, Li M, Liu D, Hu D, Gu X, Xiao Z （通讯作者） Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies. Sci Bull 2016 61(9):670-681
Xiao Z （通讯作者） CuS Nanoparticles: clinically favorable materials for photothermal therapy Nanomedicine 2014 9(3):373-5
Wu J, Kamaly N, Shi J, Zhao L, Xiao Z, Hollett G, John R, Ray S, Xu X, Zhang X, Kantoff PW, Farokhzad OC Development of multinuclear polymeric nanoparticles as robust protein nanocarriers Angew Chem Int Ed Engl 2014 53(34):8975-9
Xiao Z, Farokhzad OC Aptamer-functionalized nanoparticles for medical applications: challenges and opportunities ACS Nano 2012 6(5):3670-3676
Xiao Z, Ji C, Shi J, Pridgen E, Frieder J, Wu J, Farokhzad OC DNA self-assembly of targeted near infrared-responsive gold nanoparticles for cancer thermo-chemotherapy Angew Chem Int Ed Engl 2012 51(47):11853-11857
Xiao Z, Levy-Nissenbaum E, Alex F, Luptak A, Teply B, Chan J, Shi J, Diggar E, Cheng J, Langer R, et al. Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection ACS Nano 2012 6 (1):696-704
Kamaly N, Xiao Z (co-first author) （共同第一作者）,Valencia PM, Radovic-Moreno AF, Farokhzad OC Targeted polymeric therapeutic nanoparticles: design, development and clinical translation Chem Soc Rev 2012 41(7):2971-3010
Shi J, Xiao Z, Kamaly N, Farokhzad OC Self-assembled Targeted Nanoparticles: Evolution of Technologies and Bench to Bedside Translation Acc Chem Res 2011 44(10):1123-34
Shi J, Xiao Z, Votruba AR, Viols C, Farokhzad OC Differently Charged Hollow Core/shell Lipid-polymer-lipid Hybrid Nanoparticles for Small Interfering RNA Delivery Angew Chem Int Ed Engl 2011 50(31):7027-7031
Gao W, Xiao Z, Radovic-Moreno A, Shi J, Langer R, Farokhzad OC Progress in siRNA Delivery: A Multifunctional Approach by Polymeric Nanoparticles Methods in Mol Biol 2010 629(1):53-67
Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X, Chen Y Single Molecule Imaging Reveals Transforming Growth Factor-β-induced Type II Receptor Dimerization Proc Natl Acad Sci U S A 2009 106(37):15679-15683
Liu Q, Chen B, Wang Q, Shi X, Xiao Z, Lin J, Fang X Carbon Nanotubes as Molecular Tansporters for Walled Plant Cells Nano Lett 2009 9(3):1007-1010
Xiao Z, Shangguan D, Cao ZC, Fang X, Tan W Cell-specific Internalization Study of an Aptamer from Whole Cell Selection Chemistry 2008 14(6):1769-1775
Yang R, Jin J, Chen Y, Shao N, Kang H, Xiao Z, Tang Z, Wu Y, Zhu Z, Tan W. Identification of Liver Cancer-Carbon Nanotube-Quenched Fluorescent Oligonucleotides: Probes that Fluoresce upon Hybridization J.Am.Chem.Soc 2008 130(26):8351–8358
Xiao Z, Zhang W, Yang Y, Xu L, Fang X Single-molecule diffusion study of activated EGFR implicates its endocytic pathway Biochem Biophys Res Commun 2008 369(2):730-734
Xiao Z, Ma X, Jiang Y, Liao J, Yue J, Fang X Single-Molecule Study of Lateral Mobility of Epidermal Growth Factor Receptor 2/HER2 on Activation J Phys Chem B 2008 112(13):4140-4145
Shangguan D, Meng L, Cao Z, Xiao Z, Fang X, Li Y, Cardona D, Witek RP, Liu C, Tan W. Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells Anal Chem 2008 80(3):721-728
Shangguan D, Tang Z, Mallikaratchy P, Xiao Z, Tan W Optimization and Modifications of Aptamers Selected from Live Cancer Cell Lines Chembiochem 2007 8(6):603-606
Ma X, Wang Q, Jiang Y, Xiao Z, Fang X, Chen Y Optimization and Modifications of Lateral Diffusion of TGF-? Type I Receptor Studied by Single-Molecule Imaging Biochem Biophys Res Commun 2007 356(1):67–71
Xu W, Xiao Z, Zhang T Mechanical Properties of Silicone Elastomer on Temperature in Biomedical Application Materials Letters 2005 59(17):2153-2155