导师姓名： 朱亮 专业代码： 100700
性别： 男 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： Email: zhuliang17@126.com (常用) or jyzhul@shsmu.edu.cn; Phone: or -776941导师寄语：放飞科学梦想 携手学海翱翔
邮编： 200025 邮箱地址： jyzhul@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤/干细胞活性小分子代谢组及其靶向调控药理学
导师寄语：放飞科学梦想 携手学海翱翔
药物新靶点确认及高内涵分析

社会任职
药理学教授、药理学首任首席教师
药理学科实验室主任
国家医学考试/执业医师考试专家委员会委员、上海市药理学会常务理事、上海研发公共服务平台专家
院技术平台专家委员会委员、IACUC委员
药理学与化学生物学系常务副主任
上海转化医学协同创新中心办公室 主任、核心支撑平台主任

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
7 Bcl-2靶向药物重定位克服肺癌多代EGFR-TKI获得性耐药临床前研究 大学生创新训练计划2020国家级项目（指导教师） 2019-07~2021-07 1万元 课题负责人
** ALDH1诱导非小细胞肺癌EGFR-TKI获得性耐药的ROS-RCS代谢重编程机制 国家自然科学基金 2019-01~2022-12 68.4万元 课题负责人
** 非小细胞肺癌三代EGFR-TKIs获得性耐药的Axl相关机制研究 大学生创新训练计划2018国家级项目（指导教师） 2017-07~2019-07 1万元 课题负责人
** 基于靶向代谢组学的肺腺癌干细胞葡萄糖代谢重编程通路分配定量研究 国家自然科学基金 2016-01~2019-12 68.4万元 课题负责人
14YZ032 多能干细胞肾上腺素递质自分泌信号环路机制及其药物小分子调控特征 上海市教委科研创新基金 2014-01~2016-12 8万元 课题负责人
2014ZX**-005 左沙托烷（1.1类）临床前研究 国家“重大新药创制”科技重大专项 2014-01~2016-12 428.56万元 子课题负责人
2013-52 上海高校教师产学研践习计划 上海市教委 2013-09~2015-09 5万元 课题负责人
2013/45 干细胞分化过程递质轮廓分析 教育部留学回国人员科研基金 2013-01~2015-12 2万元 课题负责人
12ZR** 恶性畸胎瘤干细胞非神经源性谷氨酸递质信号系统及其自分泌环路机制 上海市自然科学基金 2012-07~2015-06 10万元 课题负责人
2012ZX09303-003 精神药物新药临床评价研究技术平台精神药物转化医学的代谢组学研究 国家重大新药创制科技重大专项 2012-01~2015-12 266万元 课题参与人
2011DFA33180 AMPA受体和M1受体协同调控机制及靶标药物研究 国家国际合作专项 2012-01~2014-12 179万元 课题参与人
S30201 NSC分化过程经典递质动态轮廓分析 上海市重点学科开放课题 2011-05~2013-05 10万元 课题负责人
2009ZX09301-007 综合性新药研究技术开发大平台 国家“新药创制”科技重大专项 2010-09~2012-03 150万元 子课题负责人
2009ZX09103-077 具有多靶点作用抗老年性痴呆候选药物XQ509的研究 国家“新药创制”科技重大专项 2009-06~2011-06 150万元 课题参与人
2008-16 中法科学与应用基金会（FFCSA）博士后基金 FFCSA 2008-10~2010-04 50万元 课题负责人
** 异位增强M1受体信号偶联效率及其别构作用机制 国家自然基金 2008-01~2010-12 16万元 课题负责人
06BZ012 别构调节胆碱M1受体在阿尔茨海默病体外模型的效应及机制 上海市教委,发展基金 2007-01~2008-12 6万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chun-Shuang MA, Qian-Ming LV, Ke-Ren ZHANG, Ya-bin TANG, Yu-Fei ZHANG, Ying SHEN, Hui-Min LEI, Liang ZHU （通讯作者） NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells Acta Pharmacologica Sinica 2020 Epub
Qian Liang, Wei-ming Gu, Ke Huang, Ming-yu Luo, Jing-hua Zou, Guang-lei Zhuang, Hui-min Lei, Hong-zhuan Chen, Liang Zhu* （通讯作者）, Lu Zhou*, Ying Shen* HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells Acta Pharmacol. Sin 2020 Epub
Yu-Fei ZHANG, Yang WANG, Ke-Ren ZHANG, Hui-Min LEI, Ya-Bin TANG, Liang ZHU （通讯作者） Development and validation of a rapid, robust and sensitive UPLC-QQQ-MS/MS method for simultaneous quantification of GSH metabolism in lung cancer cells J Chromatogr B 2020 1148:122145
Huang K, Liang Q, Zhou Y, Jiang LL, Gu WM, Luo MY, Tang YB, Wang Y, Lu W, Huang M, Zhang SZ, Zhuang GL, Dai Q, Shen QC, Zhang J, Lei HM, Zhu L, Ye DY, Chen HZ, Zhou L, Shen Y A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer Cell Metab 2019 30(6):1107-19
Yang WANG, Cong-Hui WANG, Yu-Fei ZHANG, Liang ZHU（指导）, Hui-Min LEI*, Ya-Bin TANG* UPLC-MS-based metabolomics reveals metabolic dysregulation in ALDH1A1-overexpressed lung adenocarcinoma cells Metabolomics 2019 15(4):52-63
Hui-Min Lei, Ke-Ren Zhang, Cong-Hui Wang, Yang Wang, Guang-Lei Zhuang, Li-Ming Lu, Jian Zhang, Ying Shen, Hong-Zhuan Chen, Liang Zhu* （通讯作者） ALDH1A1 confers erlotinib resistance via facilitating the ROS–RCS metabolic pathway in lung adenocarcinomas Theranostics 2019 9(24):7122-39
张义朋（#）, 黄华艳（#）, 仰昳婕（#）, 徐懂懂（#）, 张可人*, 朱亮（审校作者）, （#二年级科创本科生） 受体酪氨酸激酶AXL在肿瘤耐药中的作用研究进展 上海交通大学学报医学版 2018 38(07): 819-824
Liu X, Zhang F, Zhang Y, Li X, Chen C, Zhou M, Yu Z, Liu Y, Zhao Y, Hao T, Tang Y, Zhu L, Xie L, Gu H, Shao H, Xia F, Yin C, Tao M, Xie J, Zhang CC, Ynag Y, Sun H, Chen GQ, Zheng JK. PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21 Cell Rep 2018 23: 1461-75
Dong JK, Lei HM, Liang Q, Tang YB, Wang Y, Zhang SZ, Li WB, Tong YG, Zhuang GL, Zhang L, Chen HZ*, Zhu L* （通讯作者）, Shen Y* Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase Theranostics 2018 8: 1808-23
Ma PF, Fu YJ, Cai MC, Yan J, Jing Y, Zhang SZ, Chen MJ, Wu J, Shen Y, Zhu L, Chen HZ, Gao WQ, Wang MZ, Gu ZY, Bivona TG, Zhao XJ, Zhuang GL Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer Nature Commun 2017 8(1):823-829
孟爽,汪洋,雷绘敏,唐亚斌,朱亮 基于液相色谱-高分辨质谱技术的厄洛替尼获得性耐药肺腺癌细胞代谢轮廓分析 上海交通大学学报 2017 37(5):571-577
Liang Zhang, Lin Zhang, Jianfeng Xiao, Jianrong Xu, Tianran Fu, Zhiwei Cao, Liang Zhu, Hong-Zhuan Chen, Xu Shen, and Hualiang Jiang Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis Cell Res 2016 26(12):1330-1344
Song Y, Yu P, Lu JJ, Lu HZ, Zhu L, Yu ZH, Chen HZ, Cui YY A mucoactive drug carbocisteine ameliorates steroid resistance in rat COPD model Pulm Pharmacol Ther 2016 39:38-47
Lu JJ, Xu GN, Yu P, Song Y, Wang XL, Zhu L, Chen HZ, Cui YY The activation of M3 mAChR in airway epithelial cells promotes IL-8 and TGF-beta1 secretion and airway smooth muscle cell migration Respir Res 2016 17:25
Zhang C, Ding XP, Zhao QN, Yang XJ, An SM, Wang H, Xu L, Zhu L （通讯作者）, Chen HZ Role of α7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells Oncotarget 2016 7(37):59199-59208
Lin Teng, Hui-Min Lei, Fan Sun, Shi-Min An, Ya-Bin Tang, Shuang Meng, Cong-Hui Wang, Ying Shen, Hong-Zhuan Chen, Liang Zhu （通讯作者） Autocrine glutamatergic transmission for the regulation of embryonal carcinoma stem cells Oncotarget 2016 7(31):49552-49564
安世民,丁旭苹,朱亮 （通讯作者） 基于多能干细胞的高内涵筛选平台在药物研发中的应用 中国新药杂志 2015 24(2):171-176
安世民,丁旭苹,朱亮 （通讯作者） 非小细胞肺癌分子分型与信号调控网络 中国新药杂志 2015 24(24):40-45
Song Y, Lu HZ, Xu JR, Wang XL, Zhou W, Hou LN, Zhu L, Yu ZH, Chen HZ, Cui YY Carbocysteine restores steroid sensitivity by targeting histone deacetylase 2 in a thiol/GSH-dependent manner Pharmacol Res 2015 91:88-98
Fan Sun, Xu-Ping Ding, Shi-Min An, Ya-Bin Tang, Xin-Jie Yang, Lin Teng, Chun Zhang, Ying Shen, Hong-Zhuan Chen, Liang Zhu （通讯作者） Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling Sci Rep 2015 5:15950
Song FF, Xia LL, Ji P, Tang YB, Huang ZM, Zhu L, Zhang J, Wang JQ, Zhao GP, Ge HL, Zhang Y, Wang Y Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation Oncogenesis 2015 4:e159
Fan Sun, Xin-Jie Yang, Hao-Yu Lv, Ya-Bin Tang, Shi-Min An, Xu-Ping Ding, Wen-Bin Li, Lin Teng, Ying Shen, Hong-Zhuan Chen, Liang Zhu （通讯作者） Beta2-adrenoreceptor-mediated proliferation inhibition of embryonic pluripotent stem cells J Cell Physiol 2015 230(1):2640-6
Yabin Tang, Fan Sun, Lin Teng, Wenbin Li, Shimin An, Chun Zhang, Xinjie Yang, Haoyu Lv, Xuping Ding, Liang Zhu （通讯作者）, Hongzhuan Chen Simultaneous determination of the repertoire of classical neurotransmitters released from embryonal carcinoma stem cells using online microdialysis coupled with hydrophilic interaction chromatography-tandem mass spectrometry Anal Chim Acta 2014 849:70-79
L ZHU, B DERIJARD, K CHAKRABANDHU, BS WANG, HZ CHEN, AO HUEBER Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death Cancer Lett 2014 354(2):355-64
王申捷（科创本科生）,孙凡,朱亮（审校作者） 选择性5-羟色胺再摄取抑制剂的临床应用 现代医学进展 2014 (3):571-574
孙楷（科创本科生）,孙凡,朱亮（审校作者） 单胺氧化酶抑制剂在临床方面的应用 现代生物医学进展 2014 (6):1180-1182
安世民,丁旭苹,朱亮 （通讯作者） 肺癌干细胞生物学特性研究进展 生命科学 2014 26(8):790-97
Lin Teng, Ya-Bin Tang, Fan Sun, Shi-Min An, Chun Zhang, Xin-Jie Yang, Hao-Yu Lv, Qin Lu, Yong-Yao Cui, Jin-Jia Hu, Liang Zhu （通讯作者）, Hong-Zhuan Chen Nonneuronal release of GABA by embryonic pluripotent stem cells Stem Cells Dev 2013 22:2944-53
Yumei Cheng, Yongzhen Liu, Hao Wang, Juan Li, Jin Ren, Liang Zhu （通讯作者）, Likun Gong 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats J Ethnopharmacol 2013 145(1):85-93
Xu GN, Yang K, Xu ZP, Zhu L, Hou LN, Qi H, Chen HZ and Cui YY Protective effects of anisodamine on cigarette smoke extract-induced airway smooth muscle cell proliferation and tracheal contractility Toxicol Appl Pharmacol 2012 262(1):70-79
TANG Ya-Bin, TENG Lin, SUN Fan, WANG Xiao-Lin, PENG Liang, Cui Yong-Yao, HU Jin-Jia, LUAN Xin, ZHU Liang （通讯作者）, CHEN Hong-Zhuan Determination of glycine in biofluid by hydrophilic interaction chromatography coupled with tandem mass spectrometry and its application to the quantification of glycine released by embryonal carcinoma stem cells J Chromatogr B 2012 15:61-6
Xu Z.P., Yang K., Xu G.N., Zhu L., Hou L.N., Zhang W.H., Chen H.Z. and Cui, Y.Y Role of M3 mAChR in in vivo and in vitro models of LPS-induced inflammatory response Int Immunopharmacol 2012 14(3):320-7
Xu ZP, Devillier P, Xu GN, Zhu L, Zhou W, Hou LN, Tang YB, Yang K, Yu ZH, Chen HZ, Cui YY TNF-α-induced CXCL8 production by A549 cells: Involvement of the non-neuronal cholinergic system Pharmacol Res 2012 68(1):16-23
Xu ZP, Wang H, Hou LN, Xia Z, Zhu L, Chen HZ, Cui YY Modulatory effect of anisodamine on airway hyper-reactivity and eosinophilic inflammation in a murine model of allergic asthma Int Immunopharmacol 2011 11(2):260-5
Gao X, Yao L, Song Q, Zhu L, Xia Z, Xia H, Jiang X, Chen J, Chen H The association of autophagy with polyethylenimine-induced cytotoxicity in nephritic and hepatic cell lines Biomaterials 2011 32(33):8613-25
Zheng J, Feng X, Hou L, Cui Y, Zhu L, Ma J, Xia Z, Zhou W, Chen H Latanoprost Promotes Neurite Outgrowth in Differentiated RGC-5 Cells via the PI3K-Akt-mTOR Signaling Pathway Cell Mol Neurobiol 2011 31(4):597-604
Song MK, Cui YY, Zhang WW, Zhu L, Lu Y, Chen H Z. The facilitating effect of systemic administration of Kv7/M channel blocker XE991 on LTP induction in the hippocampal CA1 area independent of muscarinic activation. Neurosci Lett 2010 461(1):25-9.
Cui Y, Devillier P, Kuang X, Wang H, Zhu L, Xu Z, Xia Z, Zemoura L, Advenier C, Chen H. Tiotropium reduces lung inflammation in a model of chronic gastro-oesophageal reflux. Eur Respir J. 2010 35(6):1370-6
Zhu X, Zhou W, Cui Y, Zhu L, Li J, Feng X, Shao B, Qi H, Zheng J, Wang H, Chen H. Pilocarpine protects cobalt chloride-induced apoptosis of RGC-5 cells: involvement of muscarinic receptors and HIF-1 alpha pathway Cell Mol Neurobiol 2010 30(3):427-35
Zhu X, Zhou W, Cui Y, Zhu L, Li J, Xia Z, Shao B, Wang H, Chen H. Muscarinic activation attenuates abnormal processing of beta-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells. Biochem Biophys Res Commun.? 2009 384(1):110-3.
Cui YY, Zhu L, Wang H, Advenier C, Chen HZ and Devillier P. Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux. Life Sci 2008 82:949-955.
Zhang WW, Song MK, Cui YY, Wang H, Zhu L, Niu YY, Yang LM, Lu Y, Chen HZ. Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine. Neurosci Lett. 2008 443(3):241-5
Niu YY, Zhu L （共同第一作者）, Cui YY, Liu HZ, Chen HZ, Lu Y. The absolute configuration plays an important role in muscarinic activity of BGT-A and its analogs Bioorg Med Chem 2008 16(24):10251-6.
Zhu L, Yang LM, Cui YY, Zheng PL, Niu YY, Wang H, Lu Y, Ren QS, Wei PJ and Chen HZ. Stereoselectivity of satropane, a novel tropane analogue, on iris muscarinic receptor activation and intraocular hypotension. Acta Pharmacol Sin 2008 29(2):177-184
Wei Zhou, Xu Zhu, Liang Zhu, Yongyao Cui, Hao Wang, Hong Qi, Qiushi Ren, Hongzhuan Chen. Neuroprotection of muscarinic receptor agonist pilocarpine against glutamate-induced apoptosis in retinal neurons. Cell Mol Neurobiol 2008 28(2):263-75
Li J, Shao B, Zhu, L, Cui Y, Dong C, Miezan Ezoulin J M, Gao X, Ren Q, Heymans F, Chen H. PMS777, A Bis-interacting Ligand for PAF Receptor Antagonism and AChE Inhibition, Attenuates PAF-induced Neurocytotoxicity in SH-SY5Y Cells. Cell Mol Neurobiol. 2008 28:125-136
Niu YY, Yang LM, Deng KM, Yao JH, Zhu L, Chen CY, Zhang M, Zhou JE,?Shen TX, Chen HZ and Lu Y. Quantitative structure-selectivity relationship for M2 selectivity between M1 and M2 of piperidinyl piperidine derivatives as muscarinic antagonists. Bioorg Med Chem Lett. 2007 2007 17(8):2260-6
Zhu L, Cui YY, Feng JM, Wu XJ, Chen HZ. Aceclidine and pilocarpine interact differently with muscarinic receptor in isolated rabbit iris muscle. Life Sci. 2006 78(14):1617-32