导师姓名： 张良 专业代码： 100700
性别： 男 专业名称： 药学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 邮件: liangzhang2014@sjtu.edu.cn, zhangliang1980@gmail.com. 电话: -776942.
邮编： 200025 邮箱地址： liangzhang2014@sjtu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤相关化学修饰酶的分子机制研究
肿瘤相关修饰酶的新型抗肿瘤靶向药物发现

社会任职
中国药理学会会员
中国化学会会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** DNA去甲基化途径关键酶Tet2的先导化合物发现及其化学干预 国家自然科学基金委重大研究计划（培育） 2019-01~2021-12 60万元 课题负责人
** 基于化学生物学修饰的药物酶靶标功能研究和新药发现 国家自然科学基金委 (优秀青年科学基金项目) 2018-01~2020-12 130万元 课题负责人
** 白血病PRPS2耐药机制研究以及抗耐药先导物发现和优化 上海市教委 2016-01~2017-12 35万元 课题参与人
** 胸腺嘧啶DNA转葡糖基酶的催化机制及功能调控研究 国家自然科学基金委 (面上项目) 2016-01~2019-12 65万元 课题负责人
** 985新药平台队伍配套 上海交通大学 2015-03~2018-12 30万元 课题参与人
BJ** 海外人才引进项目 上海交通大学 2015-01~2019-12 200万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Siqi Shen, Xudong Hang, Jingjing Zhuang, Lin Zhang, Hongkai Bi, Liang Zhang （通讯作者） A back-door Phenylalanine coordinates the stepwise hexameric loading of ACP by the fatty acid biosynthesis enzyme β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) International Journal of Biological Macromolecules 2019 128, 5-11
Xiao Zhang, Lian-Huan Wei, Yuxin Wang, Yu Xiao, Jun Liu, Wei Zhang, Ning Yan, Gubu Amu, Xinjing Tang, Liang Zhang （通讯作者）, Guifang Jia Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates PNAS 2019 116(8):2919-2924
Tianran Fu, Liping Liu, Qing-Lin Yang, Yuxin Wang, Pan Xu,Lin Zhang, Shien Liu, Qing Dai, Quanjiang Ji, Guo-Liang Xu, Chuan He,Cheng Luo, Liang Zhang （通讯作者） Thymine DNA glycosylase recognizes the geometry alteration of minor groove induced by 5-formylcytosine and 5-carboxylcytosine Chemical Science 2019 10, 7407-7417
Yihong Zhang, Xiuqun Zou, Wenli Qian, Xiaoling Weng, Lin Zhang, Liang Zhang, Shuang Wang, Xuan Cao, Li Ma, Gang Wei, Yingjie Wu, Zhaoyuan Hou Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis Cell Death Differ 2018 26, 565-579
Jason Karpus, Michael Bosscher, Ifedayo Ajiboye, Liang Zhang, Chuan He Chromate Binding and Removal by the Molybdate-Binding Protein ModA Chembiochem 2017 18, 633
Lin Zhang, Jianfeng Xiao, Jianrong Xu, Tianran Fu, Zhiwei Cao, Liang Zhu, Hong-Zhuan Chen, Xu Shen, Hualiang Jiang, Liang Zhang （通讯作者） Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis Cell Research 2016 26(12),1330-1344
Changliang Shan, Shannon Elf, Quanjiang Ji, Hee-Bum Kang, Lu Zhou, Taro Hitosugi, Lingtao Jin, Ruiting Lin, Liang Zhang, JaeHo Seo, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Jessica Sudderth, Lei Jiang, Ralph J.De Berardinis, Shaoxiong Wu, Yuancheng Li, Hui Mao, Peng R.Chen, Dongsheng Wang, GeorgiaZhuo Chen, Sagar Lonial, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Daniel J. Brat, Keqiang Ye, Titus J. Boggon, Chuan He, Sumin Kang, Jun Fan, Jing Chen Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth Molecular Cell 2014 55(4):552-65
W. Z. Chen, L. Zhang, G. Q. Zheng, Y. Fu, Q. J. Ji, F. G. Liu, H. Chen, C. He. Crystal structure of the RNA demethylase ALKBH5 from zebrafish FEBS Lett 2014 588, 892
Liang Zhang, Weizhong Chen, Lakshminarayan M. Iyer, Jennifer Hu, Gloria Wang, Ye Fu, Miao Yu, Qing Dai, L. Aravind§, Chuan He A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-Methylcytosine to 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine J. Am. Chem. Soc. 2014 136(13):4801-4804
L. Zhou, M. Bosscher, C. S. Zhang, S. ozcubukcu, L. Zhang, W. Zhang, C. J. Li, J. Z. Liu, M. P. Jensen, L. H. Lai, C. He A protein engineered to bind uranyl selectively and with femtomolar affinity Nat. Chem 2014 6, 236
F. K. Deng, L. Zhang, Y. T. Wang, O. Schneewind, S. B. H. Kent. Total chemical synthesis of the enzyme Sortase AΔN59 with full catalytic activity Angew. Chem. Int. Ed. Engl. 2014 53, 4662
Q. J. Ji, L. Zhang, M. B. Jones, F. Sun, X. Deng, H. H. Liang, P. Brugarolas, N. Gao, S. N. Peterson, L. F. Lan, T. Bae, C. He. Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR Proc. Natl. Acad. Sci. USA 2013 110, 9183
Liang Zhang, Keith E. Szulwach, Gary C. Hon, Chun-Xiao Song, Beomseok Park, Miao Yu, Xingyu Lu, Qing Dai, Xiao Wang, Craig R. Street, Huiping Tan, Jung-Hyun Min, Bing Ren, Peng Jin, Chuan He Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing Nature Communications 2013 4:1517-1526
J. J. Liu, Y. N. Yue, D. L. Han, X. Wang, Y. Fu, L. Zhang, G. F. Jia, M. Yu, Z. K. Lu, X. Deng, Q. Dai, W. Z. Chen, C. He A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation Nat. Chem. Biol 2013 10, 93
22.T. Hitosugi, L. Zhou, J. Fan, S.Elf, L. Zhang, J. Xie, Y. Wang, T. L. Gu, M. Ale?kovi?, G. LeRoy, Y. Kang, H. B. Kang, J. H. Seo, C. Shan, P. Jin, W. Gong, S. Lonial, M. L. Arellano, H. J. Khoury, G. Z. Chen, D. M. Shin, F. R. Khuri, T. J. Boggon, S. Kang, C. He, J. Chen Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation Nat. Commun. 2013 4. 1790
C. Q. Yi,B. Chen, B. Qi, W. Zhang, G. F. Jia, L. Zhang, C. J. Li, A. R. Dinner, C. G. Yang, C. He Duplex interrogation by a direct DNA repair protein in search of base damage Nat. Struct. Mol. Biol 2012 19, 671
Quanjiang Ji, Liang Zhang （共同第一作者）, Fei Sun, Xin Deng, Haihua Liang, Taeok Bae, Chuan He Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response J. Biol. Chem 2012 287(25):21102-21109
T. Hitosugi, L. Zhou, S. Elf, J. Fan, H. B. Kang, J. H. Seo, C. L. Shan, Q. Dai, L. Zhang, J. X. Xie, T. L. Gu, P. Jin, M. Ale?kovi?, G. LeRoy, Y. B. Kang, J. A. Sudderth, R. J. DeBerardinis, C. H. Luan, G. Z. Chen, S. Muller, D. M. Shin, T. K. Owonikoko, S. Lonial, M. L. Arellano, H. J. Khoury, F. R. Khuri, Benjamin, H. Lee, K. Q. Ye, T. J. Boggon, S. Kang, C. He, J. Chen Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth Cancer Cell 2012 22, 585
Liang Zhang, Miao Yu, Chuan He Mouse Tet1 Protein can Oxidize 5mC to 5hmC and 5caC on Single-stranded DNA Acta Chim. Sinica. 2012 70:2123-2126.
Liang Zhang, Xingyu Lu, Junyan Lu, Haihua Liang, Qing Dai, Guo-Liang Xu, Cheng Luo, Hualiang Jiang, Chuan He Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA Nature Chemical Biology 2012 8(4):328-330
F. Sun, Y. Ding, Q. J. Ji, Z. J. Liang, X. Deng, C. C. L. Wong, C. Q. Yi, L. Zhang, S. Xie, S. Alvarez, L. M. Hicks, C. Luo, H. L. Jiang, L. F. Lan, C. He Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance Proc. Natl. Acad. Sci. USA 2012 109, 15461
Q. Dai, X. Y. Lu, L. Zhang, C. He. Synthesis of DNA oligos containing 2’-deoxy-2’-fluoro-d-arabinofura-nosyl-5-carboxylcytosine as hTDG inhibitor Tetrahedron 2012 68, 5145
M. Yu, G. C. Hon, K. E. Szulwach, C. X. Song, L. Zhang, A. Kim, X. K. Li, Q. Dai, Y. Shen, B. Park, J. H. Min, P. Jin, B. Ren, C. He. Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome Cell 2012 149, 1368
Jing Chen, Liang Zhang （共同第一作者）, Yu Zhang, Haitao Zhang, Jiamu Du, Jianping Ding, Yuewei Guo, Hualiang Jiang, Xu Shen Emodin targets the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization BMC Microbiol. 2009 9:91-102
Lingyan He, Liang Zhang （共同第一作者）, Xiaofeng Liu, Xianghua Li, Mingyue Zheng, Honglin Li, Kunqian Yu, Kaixian Chen, Xu Shen, Hualiang Jiang, Hong Liu Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination J. Med. Chem. 2009 52(8):2465-2481
Y. Feng, L. Zhang, T. C. Hu, X. Shen, K. X. Chen, H. L. Jiang, D. X. Liu A conserved hydrophobic core at Bcl-xL mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein Arch. Biochem. Biophys 2009 484, 46
Y. H. Kong, L. Zhang, Z. Y. Yang, C. Han, L. H. Hu, H. L. Jiang, X. Shen The natural product Juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization Acta Pharm. Sinicn 2008 29, 870
D. L. Wu, T. C. Hu, L. Zhang, J. Chen, J. M. Du, J. P. Ding, H. L. Jiang, X. Shen Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis Protein Sci 2008 17, 1066
D. L. Wu, L. Zhang, Y. H. Kong, J. M. Du, S. Chen, J. Chen, J. P. Ding, H. L. Jiang, X. Shen. Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori Proteins 2008 72, 1148
Liang Zhang, Yunhua Kong, Dalei Wu, Haitao Zhang, Jian Wu, Jing Chen, Jianping Ding, Lihong Hu, Hualiang Jiang, Xu Shen Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay Protein Science 2008 17(11):1971-1978
Liang Zhang, Weizhi Liu, Tiancen Hu, Li Du, Cheng Luo, Kaixian Chen, Xu Shen, Hualiang Jiang Structural basis for catalytic and inhibitory mechanisms of β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) J. Biol. Chem 2008 283(9):5370-5379
Liang Zhang, Weizhi Liu, Jianfeng Xiao, Tiancen Hu, Jing Chen, Kaixian Chen, Hualiang Jiang, Xu Shen Malonyl-CoA: acyl carrier protein transacylase from Helicobacter pylori: Crystal structure and its interaction with acyl carrier protein Protein Science 2007 16(6):1184-1192
W. Z. Liu, L. Du, L. Zhang, J. Chen, X. Shen, H. L. Jiang Helicobacter pylori acyl carrier protein: expression, purification, and its interaction with beta-hydroxyacyl-ACP dehydratase Protein Expr. Purif 2007 52, 74
C. Y. Yu, C. S. Gui, H. B. Luo, L. L. Chen, L. Zhang, H. Yu, S. Yang, W. H. Jiang, J. H. Shen, X. Shen, H. L. Jiang Folding of the SARS Coronavirus Spike Glycoprotein Immunological Fragment (SARS_S1B): Thermodynamic and Kinetic Investigation Correlating with Three-Dimensional Structural Modeling Biochemistry 2005 44, 1453
B. Wen, H. Li, D. R. Lu, X. F. Song, F. Zhang, Y. G. He, F. Li, Y. Gao, X. Y. Mao, L. Zhang, J. Qian, J. Z. Tan, J. Z. Jin, W. Huang, R. J. Deka, B. Su, R. Chakraborty, L. Jin Genetic evidence supports demic diffusion of Han culture Nature 2004 431, 302