导师姓名： 张国花 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： ghzhang2009@shsmu.edu.cn

研究方向 (点击浏览详细信息)
感觉异常的分子调控机制

社会任职
上海生理学会 理事
中国生理学会消化与营养专业委员会 委员
中国生理学会疼痛转化研究专业委员会 委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 5-HT抑制坏死性凋亡信号通路改善糖尿病胃肠神经病变的机制研究 国家自然科学基金 2018-01~2021-12 54万元 课题负责人
** 姜黄素以炎症-TRPV1为靶点治疗内脏痛的机制研究 国家自然科学基金 2013-01~2016-12 65万元 课题负责人
** 外周大麻素CB1受体对子宫内膜异位病灶神经发生及疼痛的调控作用与分子机制研究 国家自然科学基金 2011-01~2013-12 33万元 课题负责人
YG2010MS04 姜黄素及类似多酚类天然药物成分治疗内脏痛的基础研究 上海交通大学 2010-07~2012-06 5万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Han H, Liang X, Wang J, Zhao Q, Yang M, Rong W, Zhang G. （通讯作者） Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation Brain Research 2017 1663:132-40
Yang M, Wang J, Yang C, Han H, Rong W, Zhang G （通讯作者） Oral administration of curcumin attenuates visceral hyperalgesia through phosphorylation of TRPV1 in rat model of ulcerative colitis Molecular Pain 2017 13:1-11
Jiao Y, Li Q, Sun B, Zhang G （通讯作者）, Rong W. Hydrogen sulfide activates the carotid body chemoreceptors in cat, rabbit and rat ex vivo preparations. Respir Physiol Neurobiol 2015 208:15-20.
Dong L, Liang X, Sun B, Ding X,Han H,Zhang G （通讯作者）, Rong W. Impairments of the primary afferent nerves in a rat model of diabetic visceral hyposnesitivity. Mol Pain 2015 11(1):74
Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, kKuang Y, Fei J, Gu MM, Rong WF, Wang ZG. Deletion of Gpr128 results in weight loss and increased intestnal ontraction frequency. World J Gastroenterol. 2014 20(2):498-508.
Zhao Q, Yang Y, Liang X, Du G, Liu L, Lu L, Dong J, Han H, Zhang G. （通讯作者） The clinicopathological significance of neurogenesis in breast cancer. BMC Camcer 2014 14:484
Zhi L, Dong L, Kong D, Sun B, Sun Q, Grundy D, Zhang G （通讯作者）, Rong W. Curcumin acts via transient receptor potential vanilloid-1 receptors to inhibit gut nociception and reverses visceral hyperalgesia. Neurogastroenterol Motil. 2013 115(5):1221-7.
Wang YP, Sun BY, Li Q, Dong L, Zhang GH, Grundy D, Ronf WF#. Hyperpolarization-activated cyclic nucleotide-gated cation channel subtypers differentially modulate the excitability of murine small intestinal afferents. World J Gastroenterol. 2012 18(6):522-31
Han H, Lee K, Rong W, Zhang G （通讯作者） Different roles of peripheral mitogen-activated protein kinases in carrageenan-induced arthritic pain and arthritis in rats Anesthesia & analgesia 2012 115:1221-1227
Chen W, Zhang G （共同第一作者）, Marvizón JC. NMDA receptors in primary afferents require phosphorylation by Src family kinases to induce substance P release in the rat spinal cord. Neuroscience 2010 166:924-34.
Zhang G, Chen W, Marvizón JC. Src family kinases mediate the inhibition of substance P release in the rat spinal cord by μ-opioid receptors and GABA(B) receptors, but not α(2) adrenergic receptors. Eur J Neurosci 2010 32:963-73
Zhang G, Chen W, Lao L, Marvizón JC. Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization. Eur J Neurosci. 2010 31:225-37.
Zhang GH, Min SS Seol GH Lee KS, Han H, Kim YI, Han HC. Inhibition of the N-methyl-d-aspartate receptor unmasks the antinociception of endogenous opioid in the periphery. Pain 2009 31:225-37.
Zhang G, Muhammad H, Raja S, Wilson SP, Sweitzer SM. Enhanced peripheral analgesia using virally mediated gene transfer of the mu opioid receptor in mice. Anesthesiology 2008 108:305-13.
Zhang G, Sweitzer SM. Neonatal morphine enhances nociception and decreases analgesia in young rats. Brain research 2008 1199:82-90
Zhang G, Dmitrieva N, Liu Y, McGinty KA, Berkley KJ. Is endometriosis a neurovascular condition? Estrous variation in innervation, vascularization, and growth factor and cytokines content of ectopic endometrial cysts in the rat. Am J Physiol Regul Integr Comp Physiol 2008 294:162-171