导师姓名： 钮晓音 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 200025 邮箱地址： niuxiaoyin@163.com

研究方向 (点击浏览详细信息)
自身免疫病发病机制及免疫调节

社会任职
上海市免疫学会会员
中国医药教育协会毕业后与继续医学教育指导委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 前列腺素E2经MEKK2信号通路对Tfh细胞分化的调控作用及其在类风湿关节炎中的致病机制研究 国家自然科学基金 2019-01~2022-12 57万元 课题负责人
人源化抗-CD277抗体对类风湿关节炎中Th17/Treg亚群的调控作用研究 上海市卫生和计划生育委员会 2017-01~2019-12 5万元 课题负责人
YG2014MS77 MEKK2对炎症性肠病的作用机制及其肠道菌群诊断芯片的研究 上海交通大学医工交叉项目 2015-01~2017-12 10万元 课题负责人
** MEKK2/3对类风湿关节炎Th17细胞中IL-21信号通路的影响和作用机制研究 国家自然科学基金 2014-01~2016-12 23万元 课题负责人
14YZ042 MEKK2/3对Th17细胞IL-21信号通路的影响及其在类风湿关节炎中作用 上海市教育委员会 2014-01~2016-12 8万元 课题负责人
** 类风湿关节炎中诱导Tfh向Treg分化的可塑性机制研究 上海市卫生局 2013-01~2015-12 3万元 课题负责人
12ZR** Tfh向Treg分化的可塑性及其在类风湿关节炎中的调控作用 上海市科委 2012-10~2015-09 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhao Q, Cheng W, Xi Y, Cao Z, Xu Y, Wu T, Li C, Niu X （通讯作者）, Chen G. IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis Mol Immunol. 2018 93:20-30
Song J, Liu H, Zhu Q, Miao Y, Wang F, Yang F, Cheng W, Xi Y, Niu X, He D, Chen G. T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-κB. Biomed Res Int. 2018 2018:**
Xu D, Yao M, Wang Y, Yuan L, Hoeck JD, Yu J, Liu L, Yeap YYC, Zhang W, Zhang F, Feng Y, Ma T, Wang Y, Ng DCH, Niu X, Su B, Behrens A, Xu Z. MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. PLoS Biol. 2018 16(12):e**
Guo C, Wu N, Niu X, Wu Y, Chen D, Guo W. Comparison of T Helper Cell Patterns in Primary Open-Angle Glaucoma and Normal-Pressure Glaucoma. Med Sci Monit. 2018 24:1988-1996
Niu X （共同第一作者）, Deng S, Li S, Xi Y, Li C, Wang L, He D, Wang Z, Chen G. Therapeutic effect of ergotope peptides on CIA by down-regulation of inflammatory and Th1/Th17 responses and induction of regulatory T cells. Mol Med. 2016 22:608-620
Zhou L, Cao T, Wang Y, Yao H, Du G, Chen G, Niu X, Tang G. Frequently Increased but Functionally Impaired CD4+CD25+ Regulatory T Cells in Patients with Oral Lichen Planus. Inflammation. 2016 39(3):1205-15
Cheng W, Zhao Q, Xi Y, Li C, Xu Y, Wang L, Niu X （通讯作者）, Wang Z, Chen G. IFN-β inhibits T cells accumulation in the central nervous system by reducing the expression and activity of chemokines in experimental autoimmune encephalomyelitis. Mol Immunol. 2015 64(1):152-62
Xu Y, Zhu Q, Song J, Liu H, Miao Y, Yang F, Wang F, Cheng W, Xi Y, Niu X, He D, Chen G. Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis. Mediators Inflamm. 2015 2015:356040
Li C, Xi Y, Li S, Zhao Q, Cheng W, Wang Z, Zhong J, Niu X （通讯作者）, Chen G. Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation. Mol Immunol. 2015 67(2 Pt B):444-54
Niu X, Chen G. Clinical biomarkers and pathogenic-related cytokines in rheumatoid arthritis. J Immunol Res. 2014 2014:698192
Xiaoyin Niu, Guangjie Chen. IL-21 and Related Diseases. J Clin Cell Immunol. 2013 2013:1-008
Shan Li, Xiaoyin Niu, Yebin Xi, Shaohua Deng, Chengzhen Li, Qing Zhao, Guangjie Chen. T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis. Clinical and Developmental Immunology. 2013 2013:967301
Yang XO, Zhang H, Kim BS, Niu X, Peng J, Chen Y, Kerketta R, Lee YH, Chang SH, Corry DB, Wang D, Watowich SS, Dong C. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol. 2013 14(7):732-40
Tong Z, Yang XO, Yan H, Liu W, Niu X, Shi Y, Fang W, Xiong B, Wan Y, Dong C. A protective role by interleukin-17F in colon tumorigenesis. PLoS One. 2012 7(4):e34959
Niu X, He D, Deng S, Li W, Xi Y, Xie C, Jiang T, Zhang JZ, Dong C, Chen G. Regulatory immune responses induced by IL-1 receptor antagonist in rheumatoid arthritis. Mol Immunol. 2011 49(1-2):290-6
Deng S, Xi Y, Wang H, Hao J, Niu X, Li W, Tao Y, Chen G. Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis. Cell Immunol. 2010 265(2):105-10
Deng S, Xi Y, Wang H, Hao J, Niu X, Li W, Tao Y, Chen G. Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis. Cell Immunol. 2010 265(2):105-10
Niu X, He D, Zhang X, Yue T, Li N, Zhang JZ, Dong C, Chen G. IL-21 regulates Th17 cells in rheumatoid arthritis. Hum Immunol. 2010 71(4):334-41
Chen G, Zhang X, Li R, Fang L, Niu X, Zheng Y, He D, Xu R, Zhang JZ. Role of osteopontin in synovial Th17 differentiation in rheumatoid arthritis. Arthritis Rheum. 2010 62(10):2900-8
Chen M, Chen G, Nie H, Zhang X, Niu X, Zang YC, Skinner SM, Zhang JZ, Killian JM, Hong J. Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS. Eur J Immunol. 2009 39(9):2525-36