导师姓名： 贺明 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 200025 邮箱地址： heming@shsmu.edu.cn

研究方向 (点击浏览详细信息)
蛋白质修饰与疾病


社会任职
中国病理生理学会会员、生理学会会员、上海市青年教师联谊会理事、上海交通大学医学院青年联谊会委员。

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** SIRT2抑制酒精性肝病发生发展的机制研究 国家自然科学基金 2021-01~2024-12 55万元 课题负责人
** NAFLD-HCC转化中胆固醇代谢调控机制及作用研究 国家自然科学基金委员会重大研究计划培育项目 2021-01~2023-12 78万元 课题负责人
19ZR** SIRT2在衰老相关胰岛素抵抗中的作用 上海市科委自然科学基金 2019-07~2022-06 20万元 课题负责人
16PJ** SIRT7在非酒精性脂肪肝病发生发展中的作用及机制 浦江人才计划（A类） 2016-07~2018-06 20万元 课题负责人
** SIRT7 抑制非酒精性脂肪肝病发生发展的机制研究 国家自然科学基金 2015-01~2018-12 73万元 课题负责人
** MiR-17和 miR-20a在低氧诱导因子-1a 诱导白血病细胞分化中的作用 国家自然科学基金 2012-01~2015-12 60万元 课题负责人
09YZ96 肾素（原）受体在大鼠肾小球系膜细胞中表达的调节机制的研究 上海市教委 2009-01~2011-12 8万元 课题负责人
** 温度敏感性TRP离子通道在哮喘大鼠气道平滑肌表型转化中的作用 国家自然科学基金 2009-01~2011-12 20万元 课题负责人
001 MicroRNA在白血病细胞分化中的表达和作用 上海交通大学医学院青年教师提升计划 2008-12~2010-11 20万元 课题负责人
jdy07004 温度敏感性TRP 离子通道在高反应性气道组织中表达的变化及意义 上海市教委优秀青年教师科研专项基金 2008-01~2010-12 3万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
He M*, Chiang H*, Luo H*, Zheng Z*, Qiao Q, Wang L, Tan M, Ohkubo R, Mu W, Zhao S, Wu H, Chen D. An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. Cell Metabolism 2020 31(3): 580-591.e5.
Ruan X, Zhang Y, Han K, Lin L, Chen C, Yue M, Wang C, Sun Y, Zhao Q, He M. （通讯作者） SIRT7 protects hepatocytes from LPS or D-GalN/LPS-induced apoptosis by attenuating endoplasmic reticulum stress via inactivation of GRP78. Journal of Shanghai Jiaotong University (Medical Science). 2019 39(8):928-935.
Lin S, Xing H, Zang T, Ruan X, Wo L, He M （通讯作者） Sirtuins in Mitochondrial Stress: Indispensable Helpers behind the Scenes. Ageing Res Rev 2018 44:22-32. doi: 10.1016/j.arr.2018.03.006.
Han K*, Ruan X*, He M. （通讯作者） The roles of SIRT2 in the tumorigenesis and development of hepatocellular carcinoma. Journal of Shanghai Jiaotong University (Medical Science). 2018 10:1247-1251.
Wang QY, Zhou CX, Zhan MN, Tang J, Wang CL, Ma CN, He M, Chen GQ, He JR, Zhao Q. MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer. Cell Death Dis. 2018 9(7):752. doi: 10.1038/s41419-018-0715-6.
Gong X, Yu A, Tang J, Wang C, He J, Chen G, Zhao Q, He M （通讯作者）, Zhou C MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1. Exp Cell Res. 2018 pii: S0014-4827(17)30640-7. doi: 10.1016/j.yexcr.2017.11.039.
Zhan MN, Yu XT, Tang J, Zhou CX, Wang CL, Yin QQ, Gong XF, He M, He JR, Chen GQ, Zhao Q. MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1. Cell Death Dis. 2017 8(1):e2529. doi: 10.1038/cddis.2016.440.
An X, Zhang L, Yao Q, Li L, Wang B, Zhang J, He M （通讯作者）, Zhang J The receptor for advanced glycation endproducts mediates podocyte heparanase expression through NF-κB signaling pathway. Mol Cell Endocrinol. 2017 pii: S0303-7207(17)30252-6. doi: 10.1016/j.mce.2017.05.004.
Huang D, Wo L, Ruan X, Xu Y, Gong Y, Yang L, Li X, Kang Y, He M. （通讯作者） Construction of a new alcoholic liver disease mouse model. Journal of Shanghai Jiaotong University (Medical Science). 2017 37(7):906-913.
Zhang L, An X, Ruan X, Huang D, Zhou L, Xue H, Lu L, He M. （通讯作者） Inhibition of (pro)renin receptor contributes to renoprotective effects of angiotensin II type 1 receptor blockade in diabetic nephropathy. Front. Physiol. 2017 8:758. doi: 10.3389/fphys.2017.00758. eCollection 2017.
Tang J, Zhan MN, Yin QQ, Zhou CX, Wang CL, Wo LL, He M, Chen GQ, Zhao Q. Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition. Oncogenesis 2017 6(10):e387. doi: 10.1038/oncsis.2017.85.
An X, Zhang L, Yuan Y, Wang B, Yao Q, Li L, Zhang J, He M （通讯作者）, Zhang J Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression. Sci Rep. 2017 7(1):6413. doi: 10.1038/s41598-017-06844-2.
Zang T, Liu H, Wo L, Lin S, Xing H, He M. （通讯作者） Roles of SIRT2 in Glucose Lipid Metabolism. Sheng Li Ke Xue Jin Zhan. 2017 48(6): 458-462.
Zhang L, An XF, Wang QY, He M. （通讯作者） Activation of cold-sensitive channels TRPM8 and TRPA1 inhibits the proliferative airway smooth muscle cell phenotype. Lung. 2016 194(4):595-603. doi: 10.1007/s00408-016-9901-4.
Zhou CX, Wang CL, Yu AL, Wang QY, Zhan MN, Tang J, Gong XF, Yin QQ, He M, He JR, Chen GQ, Zhao Q. MiR-630 suppresses breast cancer progression by targeting metadherin. Oncotarget. 2016 7(2):1288-99.
Zhou CX, Wang CL, Yu AL, Wang QY, Zhan MN, Tang J, Gong XF, Yin QQ, He M, He JR, Chen GQ, Zhao Q. MiR-630 suppresses breast cancer progression by targeting metadherin. Oncotarget 2015 16. doi: 10.18632/oncotarget.6339.
Zhang L, He M. （通讯作者） Roles of Sirtuins in occurrence and development of chronic kidney disease. Journal of Shanghai Jiaotong University (Medical Science). 2015 35(4):594-600.
Shin J, He M （共同第一作者）, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep 2013 5: 654-665.
He M, Wang QY, Yin QQ, Tang J, Lu Y, Zhou CX, Duan CW, Hong DL, Tanaka T, Chen GQ, Zhao Q. HIF-1? down-regulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation. Cell Death Differ. 2013 20(3):408-418.
Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR, Zhao Q. MiR-124 Targets Slug to Regulate Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer. Carcinogenesis. 2013 34(3):713-722.
Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, He M, Chen GQ, He JR, Zhao Q. MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11. FEBS Lett. 2011 585(9):1363-1367.
Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q. Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis. 2011 32(1):2-9.
Han X, Yan M, An XF, He M, Yu JY. Central administration of kisspeptin-10 inhibits natriuresis and diuresis induced by blood volume expansion in anesthetized male rats. Acta Pharmacol Sin. 2010 31(2):145-149.
He M, Zhang L, Shao Y, Zhou L, Wang XF, Yao T, Lu LM. Angiotensin II type 2 receptor mediated angiotensin II and high glucose induced decrease in renal renin/prorenin receptor expression. Mol Cell Endocrinol. 2010 315(1-2):188-194.
Ten SC, Gu SY, Niu YF, An XF, Yan M, He M. Central administration of kisspeptin-10 inhibits water and sodium excretion of anesthetized male rats and the involvement of arginine vasopressin. Endocr Res. 2010 35(3):128-136.
Chen L, He M, Wang WQ. High-frequency rotation sensation function damage of the crista of the horizontal semicircular canal induced by gentamicin and its morphological basis. Acta Physiologica Sinica. 2009 61(6):559-566.
He M, Zhang L, Shao Y, Wang X, Huang Y, Yao T, Lu L. Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 2009 606(1-3):155-161
Chen L, He M, Wang WQ. High-frequency rotation sensation function damage of the crista of the horizontal semicircular canal induced by gentamicin and its morphological basis. Acta Physiologica Sinica. 2009 61(6):559-566.
An XF, He M, Feng Y, Feng H, Yu JY. Central administration of Orphanin FQ inhibits GnRH secretion by ORL1 receptor in the median eminence of freely moving ovariectomized rats. Neurosci Bull. 2009 25(1):1-6.
He M, Huang YL, Zhang L, Yao T, Lu LM. Expression of renin/prorenin receptor in rat kidney and cultured mesangial cells. Acta Physiologica Sinica. 2008 59 (6): 796-804.
Shao Y, He M, Zhou L, Yao T, Lu LM. Chronic Angiotensin (1-7) injection accelerated STZ-induced diabetic renal injure. Acta Pharmacol Sin. 2008 29(7):829-837.
An XF, Niu YF, Ten SC, Liu JS, Feng H, He M, Shen XJ. Orphanin FQ and glutamate connection in the regulation of gonadotropin-releasing hormone secretion in the preoptic area of conscious male rats. Neurosci Lett. 2008 440(2):109-112.
He M, Lu LM, Yao T. Effects of renin-angiotensin system on the regulation of renal function and chronic renal insufficiency. Sheng Li Ke Xue Jin Zhan. 2004 35(2):188-192.