导师姓名： 蔡蓉 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： ccairong@126.com

研究方向 (点击浏览详细信息)
蛋白质修饰、代谢与肿瘤和肿瘤干细胞
蛋白质修饰、代谢与心血管疾病

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** Nrf2 的SUMO1修饰应答丝氨酸饥饿通过ROS-PHGDH轴调控肝癌生长 国家自然科学基金面上项目 2019-01~2022-12 53万元 课题负责人
** SENP1调控磷酸戊糖途径抑制肿瘤细胞生长及其分子机制 国家自然科学基金面上项目 2016-01~2019-12 62万元 课题负责人
2015CB910403 代谢应激过程中蛋白质修饰的调控机制及其生理病理效应 国家重点基础研究发展计划（973计划）-子课题 2015-01~2019-12 60万元 课题参与人
13ZR** SUMO特异性蛋白酶1在心衰中的作用及分子基础 上海市自然基金 2013-07~2016-06 10万元 课题负责人
** 核基质结合区共存性增强子活化PI3Kγ基因转录的调控机制 国家自然科学基金青年项目 2009-01~2011-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang Y, Tian J, Huang C, Ma J, Hu G, Chen Y, Wang T, Cai R, Zuo Y, Tan H, Fan Q, Dong B, Xue W, Yi J, Chen G, Tu J, Cheng J. P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint. Cell Discovery 2020 6:21
Jiaqian Xu, Haoyan Gu, Zhengcao Xing, Wenlong Zhang, Jianli He, Jinke Cheng, Rong Cai （通讯作者） Mild oxidative stress reduces NRF2 SUMOylation to promote Kras/Lkb1/Keap1 mutant lung adenocarcinoma cell migration and invasion Oxidative Medicine and Cellular Longevity 2020 ID **
Jiao Ma, Bin Liu, Dan Yu, Yong Zuo, Rong Cai, Jianmin Yang,Jinke Cheng. SIRT3 deacetylase activity confers chemoresistance in AML via regulation of mitochondrial oxidative phosphorylation Br J Haematol 2019 187(1): 49-64
Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Jing Yi, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism Mol Cell 2019 75(4): 823-834
Haoyan Guo, Jiaqian Xu, Quan Zheng, Jianli He, Wei Zhou, Kezhou Wang, Xia Huang,Qiuju Fan, Jiao Ma, Jinke Cheng, Wenhan Mei, Rong Xing, Rong Cai （通讯作者） NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis Cancer Lett 2019 466: 39-48
Bin Chen, Jie Luo, Yirui Zhou, Xin Xu, Rong Cai （通讯作者）, Chunhua Ling PIASy antagonizes Ras-driven NSCLC survival by promoting GATA2 SUMOylation J Cancer 2018 9(9): 1689-1697
Tingting Yu,Yong Zuo,Rong Cai （共同第一作者）,Xian Huang,Shuai Wu,Chenxi Zhang,Y.Eugene Chin,Dongdong Li,Zhening Zhang,Nansong Xia,Qi Wang,Hao Shen,Xuebiao Yao,Zhong-Yin Zhang,Song Xue,Lei Shen,Jinke Cheng SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop J Mol Cell Biol 2017 9(2):144-153
Kezhou Wang,Wei Zhou,Qi Cai,Jinke Cheng,Rong Cai* （通讯作者）,Rong Xing* SUMOylation of KLF4 promotes IL-4 induced macrophage M2 polarization. Cell Cycle 2017 16(4):374-381
J Cai, Y Zuo, T Wang, Y Cao, R Cai, F-L Chen, J Cheng, and J Mu. A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppresive activity Oncogene 2016 35(37): 4949-56
Rong Cai, Jianmin Gu, Haipeng Sun, Xiaobing Liu,, Wenhan Mei, Yitao Qi, Song Xue, Shuxun Ren, Joseph E. Rabinowitz, Yibin Wang, Edward T.H. Yeh, and Jinke Cheng. Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy J Mol Cell Cardiol 2015 79(2):115-122
Bingting Liu, Tianshi Wang, Wenhan Mei, Dongdong Li, Rong Cai, Yong Zuo, Jinke Cheng. SUMO-specific protease 1 de-SUMOylates Sharp-1 and controls adipocyte differentiation J Biol Chem 2014 289(32):2235-864
Jianmin Gu, Yuqi Fan, Xiaobing Liu, Lihuang Zhou, Jinke Cheng, Rong Cai* （通讯作者）, Xue S* SENP1 protects against myocardial ischemia/reperfusion injury via a HIF1α-dependent pathway Cardiovasc Res 2014 104(1):83-92
Rong Cai, Tingting Yu, Chao Huang, Xuefeng Xia, Xiaobing Liu, Jianmin Gu, Song Xue, Edward T.H. Yeh, Jinke Cheng SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC1α J Biol Chem 2012 287(53):4446-470
Zhou Jiang, Qiuju Fan, Zhening Zhang, Yanqiong Zou, Rong Cai, Qi Wang, Yong Zuo, Jinke Cheng SENP1 Deficiency Promotes ER Stress-Induced Apoptosis by Increasing XBP1 SUMOylation Cell Cycle 2012 11(6):1118-22