导师姓名： 支建明 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： jyzhijm@shsmu.edu.cn

研究方向 (点击浏览详细信息)
心血管受体与心血管疾病

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** miR-1和miR-21在先兆子痫发病早期AT1受体自身抗体诱导心肌细胞凋亡中作用及机制研究 国家自然基金 2017-01~2018-12 25万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang J, Yue J, Xia Q, Jiao XY, Zhi JM （通讯作者） Angiotensin II type 1 receptor agonistic autoantibodies induces apoptosis of cardiomyocytes by downregulating miR21 in preeclampsia: a mechanism study. Am J Transl Res 2019 11(4):2339-2349
Liu F, Yang L, Zheng YQ, Zhang WH, Zhi JM （通讯作者） Effects and molecular mechanisms of AT1-AA in retinopathy of preeclampsia Acta Biochim Biophys Sin 2019 51(1):51-58
Bu SR, Wang YX, Sun SQ, Zheng YQ, Jin Z, Zhi JM （通讯作者） Role and mechanism of AT1-AA in the pathogenesis of HELLP syndrome Sci Rep 2018 8:279
Xia Q, Zhao TN, Wang M, Chen B, Zhi JM （通讯作者） Roles and possible mechanisms of autoantibodies against the angiotensin AT1 receptor in vascular calcification of rats Int J Clin Exp Pathol 2018 11(5):2314-2322
Sun SQ, Li KP, Zhi JM （通讯作者） Multiple cardiac arrests induced by pulmonary embolism in a traumatically injured patient Medicine 2017 96:49
Liu F, Wang YX, Wang XF, Zheng YQ, Jin Z, Zhi JM （通讯作者） Role of agonistic autoantibodies against type-1 angiotensin II receptor in the pathogenesis of retinopathy in preeclampsia Sci Rep 2016 6; 29036
Liu F, Zhang PP, Wang KS, Wang F, Zhi JM （通讯作者） The role of CD40 and CD40L in the pathogenesis of an experimental model of choroidal neovascularization Int J Clin Exp Pathol 2016 9(3):2960-2969
Zhang WH, Wang XF, Zheng YQ,Jin Z,Liu F, Zhi JM （通讯作者） Study of Mechanism of Agonistic Angiotensin II type-1 receptor autoantibody amplified contractile response to Ang II Acta Biochim Biophys Sin 2015 47(12):851-856
Wang HP, Zhang WH, Wang XF, Jin Z, Zheng YQ, Qin X, Zhi JM （通讯作者） Exposure to AT1 Receptor Autoantibodies during Pregnancy Increases Susceptibility of the Maternal Heart to Postpartum Ischemia-Reperfusion Injury in Rats Int J Mol Sci 2014 15;11495-11509
Jin Z, Zhang WH, Chai WR, Zheng QY, Zhi JM （通讯作者） Antibodies against AT1 Receptors Are Associated with Vascular Endothelial and Smooth Muscle Function Impairment: Protective Effects of Hydroxysafflor Yellow A PLOS ONE 2013 8(6):e67020
Jin Z, Zhang WH, Yang HL, Wang XF, Zheng YQ, Zhang QY, Zhi JM （通讯作者） Maternal treatment with agonistic autoantibodies against type-1 angiotensin II receptor in late pregnancy increases apoptosis of myocardial PLOS ONE 2013 8(10):e80709
Nie PH, Zhang L, Zhang WH, Rong WF, Zhi JM （通讯作者） The effect of hydroxy safflor yellow A on blood pressure and cardiac function J Ethnopharmacol 2012 139(3):746-750
Chai WR, Zhang WH, Jin Z, Feng YP, Kuang YP, Zhi JM （通讯作者） Angiotensin II type I receptor agonistic autoantibody-induced apoptosis in neonatal rat cardiomyocytes is dependent on the generation of tumor necrosis factor-a Acta Biochim Biophys Sin 2012 44(12):984-990
Chai WR, Zhang WH, Jin Z, Zheng YQ, Jin PY, Zhang QY. Zhi JM Hydroxysafflor yellow A attenuates renal ischemia- reperfusion injury in a rat model Lett Drug Des Discov, 2012 9(10):967-972
Jin Z, Wang J, Zhang WH, Zhang GH, Jiao XY, Zhi JM （通讯作者） Changes in cardiac structure and function in rats immunized by angiotensin type 1 receptor peptides Acta Biochim Biophys Sin 2012 43(12):970-976
Zhang L, Nie PH, Zhang GH, Rong WF, Zhi JM （通讯作者） Endothelium-independent vasodilation effect of hydroxysafflor yellow A in thoracic aorta of wistar rats J Med Plants Res 2011 5(11):2187-2191
Gao Y, Liu HR, Zhao RR, Zhi JM （通讯作者） Autoantibody against cardiac beta 1-adrenoceptor induces apoptosis in cultured neonatal rat cardiomyocytes Acta Biochim Biophys Sin 2006 38(7):443-449
Chen RF, Wang J, Jiao XY, Liu HR, Zhao RR, Zhi JM （通讯作者） Detection of serum autoantibodies against AT(1A) Receptor during the development of the four types of hypertensive rat models Acta Physiol Sin 2006 58(1):90-94
Zhi JM （通讯作者）, Chen RF, Wang J, Jiao XY, Zhao RR Comparative studies of vasodilating effects of angiotensin-(1-7) on the different vessels Acta Physiol Sin 2004 36(12):793-797
Zhi JM （通讯作者）, Chen RF, Wu H, Liu HR, Zhao RR Changes in autoantibodies against β1-adrenoceptor and M2-muscarinic receptor during development of renovascular hypertension in rats Acta Biochim Biophys Sin 2004 36(12):793-797