导师姓名： 吴学锋 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市黄浦区重庆南路280号西7楼207. 电话：, -776684；实验室电话：-776748.
邮编： 200025 邮箱地址： xuefengwu@shsmu.edu.cn

研究方向 (点击浏览详细信息)
免疫/炎症和肿瘤

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2016 国家高层次人才计划 国家高层次人才计划 2017-09~2020-09 200万元 课题负责人
N/A 新进青年教师启动计划 上海交通大学 2017-01~2019-12 20万元 课题负责人
** 泛素缀合酶Ubc13在树突状细胞中的免疫调控功能及机制研究 国自然面上项目 2017-01~2020-12 70万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell 2017 32(6):824-839.e8.
Kaneda MM, Messer KS, Ralainirina N, Li H, Leem C, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PI3Kγ is a molecular switch that controls immune suppression Nature 2016 539(7629):437-442.
Wu X, M Karin. Emerging roles of Lys63-linked polyubiquitylation in immune responses. Immunol Rev. 2015 266(1):161-74.
Wu X, W Zhang, J Font-Burgada, T Palmer, AS Hamil, SK Biswas, M Poidinger, N Borcherding, Q Xie, LG Ellies, N Lytle, LW Wu, J Yang, SF Dowdy, T Reya, M Karin. Ubiquitin-conjugating Enzyme Ubc13 Controls Breast Cancer Metastasis through a TAK1-p38 MAP Kinase Cascade. PNAS 2014 111(38): 13870-5.
Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice . J Clin Invest. 2013 123(5):2231-43.
Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M. A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1 . Cancer Cell 2013 23(5):647-59.
Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion effector-like T cells . Nat Immunol. 2012 13: 481-490.
Hu H*, Wu X* （共同第一作者）, Jin W, Chang M, Cheng X and Sun S-C. Noncanonical NF-κB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development . PNAS 2011 108(31):12827-32.
Wu X* （共同第一作者）, Zhang M* and Sun S-C. Mutual regulation between deubiquitinase CYLD and Retroviral Oncoprotein Tax . Cell & Bioscience 2011 1(1):27.
Xu G, Y-C Lo, Q Li, G Napolitano, Wu X, X Jiang, Karin M and Wu H. Crystal structure of the inhibitor of κB kinase β (IKKβ). Nature 2011 472 (7343):325-30.
Lee A*, Wu X* （共同第一作者）, H Cheng, X Zhou, X Cheng, and S-C Sun. CARMA1 regulation of Treg development involves modulation of IL-2 receptor signaling . J. Biol Chem. 2010 285(21): 15696-703.
Wu X, M Yamamoto, S Akira, and S-C Sun. Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13 . PNAS 2009 106 (49): 20836-41.
Zhang M*, Wu X* （共同第一作者）, AJ Lee, W Jin, M Chang, A Wright, T Imaizumi, and S-C Sun. Regulation of IKK-related kinases and antiviral responses by tumor suppressor CYLD . J Biol Chem. 2008 283(27): 8621-6.
Wu X, S-C Sun. Retroviral oncoprotein Tax deregulates NF-κB by activating Tak1 and mediating Tak1-IKK physical association . EMBO Rep. 2007 8(5): 510-5.