导师姓名： 李宁丽 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： Ninglixiaoxue57@163.com

研究方向 (点击浏览详细信息)
与免疫相关的转化医学研究

社会任职
上海免疫学会临床免疫学分会 委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
12JC** Cyr61上调IL-1b/Chemerin参与类风关骨破坏机制及免疫干预研究 上海市科学技术委员会 2013-01~2015-12 40万元 课题负责人
12DZ** SAA1β+/+纯合子基因型诊断试剂盒的实验室评估与性能优化 上海市科学技术委员会 2013-01~2015-12 60万元 子课题负责人
20**3 Cyr61与银屑病发生发展的相关性及其机制研究 教育部高等学校博士学科点专项科研基金资助（博导类） 2013-01~2016-12 12万元 课题负责人
12JC** 自拟蠲痹补肾方对类风湿关节炎临床疗效与作用机理研究 上海市科学技术委员会 2013-01~2015-12 15万元 子课题负责人
** 探讨IL-17/Cyr61通路介导的类风关炎症与组织损伤新机制 国家自然基金 2012-01~2015-12 60万元 课题负责人
** IL-17上调类风关滑膜细胞Cyr61表达时转录因子作用和调控研究 国家自然科学基金委员会 2011-01~2013-12 31万元 课题负责人
2010CB529103 类风湿关节炎发病的免疫学机制及其干预策略的研究 科技部 2010-01~2015-12 180万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Yue Sun, Jie Zhang, Rongfen Huo, Tianhang Zhai, Huidan Li, Pinru Wu, Xianjin Zhu, Zhou Zhou, Baihua Shen, Ningli Li* （通讯作者） Paeoniflorin inhibits skin lesions in imiquimod-induced psoriasis-like mice by down regulating inflammation International Immunopharmacology 2015 24:392–399
Xianjin Zhu, Yanfang Song, Rongfen Huo, Jie Zhang, Songtao Sun,Yong He, Huali Gao, Miaojia Zhang, Xiaoxuan Sun, Tianhang Zhai,Huidan Li, Yue Sun, Zhou Zhou, Baihua Shen,Lianbo Xiao, Ningli Li* （通讯作者） Cyr61 participates in the pathogenesis of rheumatoid arthritis by promoting proIL-1 β production by fibroblast-like synoviocytes through an AKT-dependent NF- κ B signaling pathway Clinical Immunology 2015 157:187–197
Jie Zhang, Huidan Li, Rongfen Huo, Tianhang Zhai, Haichuan Li, Yue Sun, Baihua Shen, Ningli Li* （通讯作者） Paeoni?orin selectively inhibits LPS-provoked B cell function. Journal of Pharmacological Sciences 2015 128:8-16
Sun Y, Zhang J, Zhou Z, Wu P, Huo R, Wang B, Shen Z, Li H, Zhai T, Shen B, Chen X*, Li N* （通讯作者） CCN1, a Pro-Inflammatory Factor, Aggravates Psoriasis Skin Lesions by Promoting Keratinocyte Activation Journal of Investigative Dermatology 2015 Journal of Investigative Dermatology advance online publication, 23 July 2015; doi:10.1038/jid.2015.231
Xianjin Zhu, Jie Zhang, Rongfen Huo, Jinpiao Lin, Zhou Zhou,Yue Sun, Pinru Wu, Huidan Li, Tianhang Zhai, Baihua Shen, Ningli Li* （通讯作者） Evaluation of the efficacy and safety of different tripterygium preparations on collagen-induced arthritis in rats Journal of Ethnopharmacology 2014 158:283-290
Jinpiao Lin, Rongfen Huo, Lianbo Xiao, Xianjin Zhu, Jun Xie, Songtao Sun, Yong He, Jie Zhang, Yue Sun, Zhou Zhou, Pinru Wu, Baihua Shen, Dangsheng Li, Ningli Li* （通讯作者） A Novel p53-miR-22-Cyr61 Axis in Synovial Cells Regulates Inflammation in Rheumatoid Arthritis Arthritis & Rheumatology 2014 66: 49-59
Xianjin Zhu, Lianbo Xiao, Rongfen Huo, Jie Zhang, Jinpiao Lin, Jun Xie, Songtao Sun, Yong He, Yue Sun, Zhou Zhou, Baihua Shen, Ningli Li* （通讯作者） Cyr61 Involved in Neutrophil Infiltration in Joints via Inducing IL-8 Production by Fibroblast-Like Synoviocytes in Rheumatoid Arthritis Arthritis Research & Therapy 2013 15:R187
Jun Shi, Zhou Zhou, Wen Di, Ningli Li* （通讯作者） Correlation of CD44v6 expression with ovarian cancer progression and Recurrence BMC Cancer 2013 13:182 doi:10.1186/1471-2407-13-182
Jinpiao Lin, Rongfen Huo, Li Wang, Zhou Zhou, Yue Sun, Baihua Shen, Rongfang Wang, Ningli Li （通讯作者） A novel anti-Cyr61 antibody inhibits breast cancer growth and metastasis in vivo Cancer Immunology Immunotherapy 2012 61:677-687
Jinpiao Lin,Lianbo Xiao, Guilin Ouyang, Yu Shen, Rongfen Huo, Zhou Zhou, Yue Sun, Xianjin Zhu, Jie Zhang, Baihua Shen, Ningli Li* （通讯作者） Total Glucosides of Paeony Inhibits Th1/Th17 Cells via Decreasing Dendritic Cells Activation in Rheumatoid Arthritis Cellular Immunology 2012 280: 156-163
Jinpiao Lin, Zhou Zhou, Rongfen Huo, Lianbo Xiao, Guilin Ouyang,Li Wang, Yue Sun, Baihua Shen, Dangsheng Li, Ningli Li （通讯作者） Cyr61 Promotes Th17 Differentiation through Inducing IL-6 Production by Fibroblast-Like Synoviocytes in Rheumatoid Arthritis. Journal of Immunology 2012 188(11):5776-5784
Zhou Zhou, Jinpiao Lin, Rongfen Huo, Wenkang Huang, Jian Zhang, Li Wang, Yue Sun, Baihua Shen, Ningli Li* （通讯作者） Total Glucosides of Paeony Attenuated Functional Maturation of Dendritic Cells via Blocking TLR4/5 Signaling in vivo. International Immunopharmacology 2012 12:275-282
Li Wang, Jinpiao Lin, Zhou Zhou, Rongfen Huo, Baihua Shen,Yue Sun, Ningli Li （通讯作者） Up-regulation of Th17 cells may underlie inhibition of Treg development caused by immunization with activated syngeneic T cells PloS ONE 2011 6(11):27289-27300
Yan Zhang, Li Wang, Dangsheng Li, Ningli Li （通讯作者） Taming regulatory T cells by autologous T cell immunization: a potential new strategy for cancer immune therapy Int Immuunopharm 2009 9:593-595
Qiuyu Zhang, Juanjuan Wu, Qi Cao, Lianbo Xiao, Li Wang, Dongyi He, Guilin Ouyang, Jinpiao Lin, Baihua Shen, Yuan Shi, Yan Zhang, Dangsheng Li, Ningli Li （通讯作者） A Critical Role of Cyr61 in IL-17-dependent Proliferation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis Arthritis & Rheumatology 2009 60(12):3602-3612
Fang Dua,Li Wang,Yan Zhang, Wei Jiang, Huiming Sheng, Qi Cao,Juanjuan Wu, Baihua Shen, Tianwei Shen, Jingwu Z. Zhang,Chunde Bao, Dangsheng Li, Ningli Li （通讯作者） Role of GADD45β in the regulation of synovial fluid T cell apoptosis in rheumatoid arthritis Clinical Immunology 2008 128:238-247
Huiming Sheng, Ying Wang, Yuqing Jin, Qiuyu Zhang, Yan Zhang, Li Wang, Baihua Shen, Shuo Yin, Wei Liu, Lei Cui, Ningli Li （通讯作者） A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1 Cell Reseaerch 2008 18:846-857
Qi Cao, Li Wang, Fang Du, Huiming Sheng, Yan Zhang, Juanjuan Wu, Baihua Shen, Tianwei Shen, Jingwu Zhang, Dangsheng Li, Ningli Li （通讯作者） Down-regulation of CD4+CD25+ regulatory T cells may underlie enhanced anti-tumor immunity caused by immunization with activated autologous T cells Cell Reseaerch 2007 17:627-637
Li Wang,Fang Du, Qi Cao, Huiming Shen, Baihua Shen, Yan Zhang, Yingna Diao, Jingwu Zhang, Ningli Li （通讯作者） Immunization with Autologous T Cells Enhances in vivo Anti-tumor Immune Responses mediated by up-regulation of GADD45β Cell Reseaerch 2006 16:702-712