导师姓名： 赵倩 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 重庆南路280号西二楼905室
邮编： 200025 邮箱地址： qzhao@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤细胞分化与凋亡的机制研究

社会任职
交通大学医学院病理生理学系副主任
上海市病理生理学会副理事长
上海市生物化学与分子生物学学会理事
中国病理生理学会青年委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 长链非编码RNA Lnc268在乳腺癌转移中的功能及其作用机制 国家自然科学基金 2018-01~2021-12 57万元 课题负责人
** GAPDH在乳腺癌细胞EMT及乳腺癌转移中的表达与功能研究 国家自然科学基金 2015-01~2018-12 80万元 课题负责人
** microRNA 在Snail/Twist诱导乳腺癌细胞发生上皮-间质转化中的表达调控及生物学功能 国家自然科学基金 2012-01~2015-12 57万元 课题负责人
miR-124在乳腺癌细胞EMT过程和小鼠乳腺癌转移中的功能研究 上海交通大学晨星青年****奖励计划 2011-12~2013-12 15万元 主要责任人
09SG18 低氧诱导因子-1α（HIF-1α）调控microRNAs的功能学研究 上海市教委曙光****计划 2009-12~2012-12 15万元 课题负责人
** 低氧诱导因子-1α（HIF-1α）对microRNA的调控及其在白血病细胞分化中的作用 国家自然基金委,面上项目 2009-01~2011-12 30万元 课题负责人
08JC** 白血病相关蛋白AML1-ETO剪切片断的生物学功能研究 上海市基础研究重点项目 2008-10~2010-10 30万元 课题负责人
2008AA02Z301 利用小分子化合物和RNAi研究抗白血病蛋白PLSCR1的作用网络 科技部863项目 2008-01~2010-12 86万元 课题负责人
08JC** 白血病相关蛋白AML1-ETO剪切片断的生物学功能研究 上海市科委，基础重点项目 ~2010-09 30万元

学术论文 作者论文标题期刊名出版年卷期页码
Luo GT, Xia X, Wang XF, Zhang KD, Cao J, Jiang T, Zhao Q# （通讯作者）, Qiu ZJ. miR-301a plays a pivotal role in hypoxia-induced gemcitabine resistance in pancreatic cancer Exp Cell Res. 2018 369:120-128
Wang QY, Zhou CX, Zhan MN, Tang J, Wang CL, Ma CN, He M, Chen GQ, He JR, Zhao Q. （通讯作者） MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer. Cell Death Dis. 2018 ?9(7): 752-765
Gong XF,Yu AL,Tang J,Wang CL,He JR,Chen GQ,Zhao Q,He M,Zhou CX. Exp Cell Res 2018; 362 (2):378-385. MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1. Exp Cell Res. 2018 362:378-385
Zhan MN,Yu XT,Tang J,Zhou, CX,Wang CL,Yin QQ,Gong XF,He M,He JR,Chen GQ, Zhao Q （通讯作者） MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1. Cell Death Dis. 2017 8（1）：e2529~e2529
Mi L, Zhu F, Yang X, Lu J, Zheng Y, Zhao Q, Wen X, Lu A, Wang M , Zheng M, Ji J, Sun J. The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells. Oncogene 2017 36(30):4323-4335
Tang J, Zhan MN, Yin QQ, Zhou CX, Wang CL, Wo LL, He M, Chen GQ, Zhao Q . 6(10):e387. （通讯作者） Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition. Oncogenesis 2017 6(10):e387.
Liu Y, Li F, Gao F, Xing L, Qin P, Liang X, Zhang J, Qiao X, Lin L, Zhao Q# （通讯作者）, Du L. Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling Oncotarget. 2016 7(26):40148-40159
Zhou CX, Wang CL, Yu An-Lu, Wang QY, Zhan MN, Tang T, Yin QQ, He M, He JR, Chen GQ, Zhao Q#. （通讯作者） MiR-630 suppresses breast cancer progression by targeting metadherin. Oncotarget 2016 7(2):1288-1299
Xia X,Zhang K,Cen G,Jiang T,Cao J,Huang K,Huang C, Zhao Q# （通讯作者）,Qiu Z MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation?of?SMAD4. Oncotarget 2015 6(25):21046-63
M He, Q-Y Wang, Q-Q Yin, J Tang, Y Lu, C-X Zhou, C-W Duan, D-L Hong, T Tanaka, G-Q Chen, Q Zhao （通讯作者） HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation Cell Death and Differentiation 2013 20(3):408-418
Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR, Zhao Q （通讯作者） MiR-124 Targets Slug to Regulate Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Carcinogenesis 2013 34(3):713-22
Zhang H,Wang Q,Zhao Q# （通讯作者）,Di W MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1 J Ovarian Res. 2013 6(1):84
Sun J, Zhang D, Zheng Y, Zhao Q, Zheng M, Kovacevic Z, Richardson DR Targeting the Metastasis Suppressor, NDRG1, Using Novel Iron Chelators: Regulation of Stress Fiber-Mediated Tumor Cell Migration via Modulation of the ROCK1/pMLC2 Signaling Pathway Mol Pharmacol. 2013 83(2):454-69
Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zhao Q, Zhou AW, Wang LS, Sun HD, Chen GQ Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells Nat Chem Biol 2012 8(5):486-93
Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model Blood 2012 120(24):4712-9
Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q （通讯作者） Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer Carcinogenesis 2011 32(1):2-9
Yan Z, Yang R, Jiang Y, Yang Z, Yang J, Zhao Q, Lu Y Induction of Apoptosis in Human Promyelocytic Leukemia HL60 Cells by Panaxynol and Panaxydol Molecules 2011 29;16 (7):5561-73
Chen CW, Sowden M, Zhao Q, Wiedmer T, Sims PJ Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis J Leukoc Biol. 2011 90 (2):221-33
Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, He M, Chen GQ, He JR, Zhao Q （通讯作者） MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11 FEBS Lett. 2011 585(9):1363-1367
Chen GQ, Zhang J, Zhao Q Active compounds-based discoveries about the differentiation and apoptosis of leukemic cells Chinese Sci Bull 2009 54(18): 2759-2765
Chen S, Han YH, Zheng Y, Zhao M, Yan H, Zhao Q, Chen GQ, Li D NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells Leuk Res. 2009 33(8):1108-1113
Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent Oncogene 2008 27(4):519-27
Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ Accumulation of hypoxia-inducible factor-1{alpha} protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid Haematologica 2008 93(10):1480-7
Huang Y, Zhao Q （共同第一作者）, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ. Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells. Oncogene 2006 25(50):6618-27
Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ,Zhao Q （通讯作者） Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1α protein Biochem Biophys Res Commun 2005 332(4): 1140-1145
Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells Haematologica 2005 90(12): 1607-1616
Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK J Biol Chem. 2005 280(52): 42707-42714
Zhao Q, Tao J, Zhu Q, Jia PM, Dou AX, Li X, Cheng F, Waxman S, Chen GQ, Chen SJ, Lanotte M, Chen Z, Tong JH Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation Leukemia 2004 18 (2)： 285-92
Zhao KW, Li X, Zhao Q （共同第一作者）, Huang Y, Peng ZG, Shen WZ, Zhao J, Zhou QS, Chen Z, Sims PJ, Wiedmer T, Chen GQ Protein Kinase Cdelta Mediates Retinoic Acid and Phorbol Myristate Acetate-induced Phospholipid Scramblase 1 Gene Expression: Its Role in Leukemic Cell Differentiation BLOOD 2004 104(12): 3731-8.