导师姓名： 苏冰 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： -776207
邮编： 200025 邮箱地址： bingsu@sjtu.edu.cn

研究方向 (点击浏览详细信息)
免疫调控和信号转导研究、肠道免疫和炎症相关疾病研究、血管生成机制及血管相关疾病研究

社会任职
JMCB和Cellular Immunology副主编
国家自然基金委重点项目、面上项目、青年项目等评审
濒危动植物保护生物学教育部重点实验室”学术委员会委员
上海交通大学讲席教授、****晋升委员会委员?
上海交通大学医学院医学科学研究高评委委员
中国细胞生物学学会委员
中国科学Science China Life Science/ Immunology and Cell Biology、BBRC等杂志编委
上海交通大学研究生教育指导委员会?
国家高层次人才计划评审专家
上海市欧美同学会会员
华人生物学家协会会员
《现代免疫学》杂志主编
美国免疫学协会会员
上海交通大学长聘教轨晋升委员会

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 固有淋巴细胞调控肠道免疫稳态的分子机制及生理病理功能 国家自然科学基金委员会 2020-01~2024-12 308万元 课题负责人
** Sin1(mTORC2)在肿瘤发生中的作用及其分子机制 上海市科委 2016-07~2019-06 30万元 课题负责人
15GWZK0102 上海市第四轮公共卫生三年行动计划重点学科建设项目传染病与卫生微生物学 上海市卫计委 2016-01~2017-12 36万元 子课题负责人
** 外周免疫失衡与炎症性自身免疫病相关疾病发生发展的细胞分子机制 国家自然基金委重点项目 2015-01~2019-12 320万元 课题负责人
** MEKK2在固有免疫抗细菌感染中的调控机制 国家自然基金委面上项目 2015-01~2018-12 95万元 课题负责人
13JC** MEKK2/3参与炎症性肠病中Th17/Treg细胞分化和功能的分子机制 上海市科委基础研究重点项目 2013-09~2016-08 50万元 课题负责人
PR093728 The Role of mTOR Signaling in the Regulation of RAG Expression and Genomic Stability during B Lymphocyte Development DOD Grant 2010-04~2013-04 754.6万元 课题负责人
RO1AI063348 Regulation andFunction of MEKK3in Dendritic Cells NIH 2005-04~2011-02 769.2万元 课题负责人
RO1CA097159 Mechanisms of relAActivation inPancreatic Cancer NIH 2003-09~2007-08 567万元 课题负责人
RO1HL070225 Molecular Mechanisms of MEKK3-Signaling in Angiogenesis NIH 2003-04~2007-05 771.8万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
X Ouyang, Y Han, G Qu, M Li, O Arojo, H Sun, X Liu, D Liu, LChen, Q Zou, B Su. （通讯作者） Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2. J Mol Cell Biol. 2019 2019 Feb 1;11(2):93-106
Hu ZL, Qu GJ, Yu XY, Jiang HJ, Teng XL, Ding L, Hu QW, Guo WX, Zhou Y,Wang F, Li HB, Chen L, Jiang J, Su B （通讯作者）, Liu JL, Zou Q. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+T Cells. Cell Metabolism. 2019 https://doi.org/10.1016/j.cmet.2019.05.016
Zhaoyuan Liu, Yaqi Gu, Svetoslav Chakarov, Camille Bleriot, Immanuel Kwok, Xin Chen, Amanda Shin, Weijie Huang, Regine J. Dress, Charles-Antoine Dutertre, Andreas Schlitzer, Jinmiao Chen, Lai Guan Ng, Honglin Wang, Zhiduo Liu, Bing Su （通讯作者）, and Florent Ginhoux. Fate mapping via Ms4a3 expression history traces monocyte-derived cells. Cell 2019 accepted
M Li, AS Lazorchak, X Ouyang, H Zhang, H Liu, O.A Arojo, G Qu, X Xu, X Liu, W Zhang, Q Wang, D Liu, F Li, B Su. （通讯作者） Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation. Cell Mol Immunol. 2019 2019 Jan 31. doi: 10.1038/s41423-018-0185-x.
OA. Arojo, X Ouyang, D Liu, T Meng, SM. Kaech, JP. Pereira and B Su. Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression. J Immunol 2018 2018; 201:908-915
Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B （通讯作者）, Wu ZB. Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours. Nature Communications. 2018 2018 9:4624.
Jiyu Tong, Guangchao Cao, Ting Zhang, Esen Sefik, Maria Carolina Amezcua Vesely, James P Broughton, Shu Zhu, Huabin Li, Bin Li, Lei Chen, Howard Y Chang, Bing Su, Richard A Flavell, Hua-Bing Li. m6A mRNA methylation sustains Treg suppressive functions Cell Research 2018 82.10.1038/cr.2018.7.
XYYu, XL Teng, FX Wang, YH Zheng, GJ Qu, Y Zhou, ZLHu, ZQ Wu, YZChang, L Chen, HB Li, B Su, LM Lu, ZD Liu, SC Sun, and Q Zou. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. J. Exp. Med. 2018 90. 2018. 3;215(9):2463-2476.
Xu YY, Ouyang XX,Yan LC, Zhang ML, Hu ZL, Gu JM, Fan XM, Zhang L, Zhang JF, Xue S, Chen GQ, Su B （通讯作者）, and Liu JL Sin1 regulates ischaemia-induced microthrombosis through integrin?αIIbβ3-mediated outside-in signaling and hypoxia responses in platelets. Arteriosclerosis, Thrombosis, and Vascular Biology. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018 2018 Dec;38(12):2793-2805.?
XM Fan, CH Wang,PL Shi,W Gao, JMGu,Y Geng,WL Yang,NB Wu,Y Wang,Y Xu,X Chen, L Zhang,KM Wang,B Su （通讯作者）, JL Liu. Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice. Blood Adv. 2018 2018 Jun 26;2(12):1439-1448.?
XY Yu, YM Lao, XL Teng, S Li, Y Zhou, FX Wang, XWGuo, SY Deng,YZ Chang, XF Wu, ZD Liu, L Chen, LM Lu, JK Cheng, B Li, B Su, J Jiang,HB Li , CX Huang, J Yi , Q Zou. ENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature Communications. 2018 2018: 9:3157
Tan R, Nakajima S, Wang Q, Sun H, Xue J, Wu J, Hellwig S, Zeng X,?Yates NA, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B （通讯作者）, Lan L. Nek7 protects telomeres from oxidative DNA damage by phosphorylation and stabilization of TRF1 Mol Cell 2017 2765(17):30041-2.
Zhu H, Lou F, Yin Q, Gao Y, Sun Y, Bai J, Xu Z, Liu Z, Cai W, Ke F, Zhang L, Zhou H, Wang H, Wang G, Chen X, Zhang H, Wang Z, Ginhoux F, Lu C, Su B, Wang H. RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease. EMBO Mol Med. 2017 9(5):589-604
Liu W, Liu X, Li Y, Zhao J, Liu Z, Hu Z, Wang Y, Yao Y, Miller AW2, Su B, Cookson MR, Li,KangZ LRRK2?promotes?the?activation?of?NLRC4?inflammasome?during?Salmonella? J Exp Med. 2017 214(10):3051-3066.
Zepp JA,Zhao J,Liu C,Bulek K,?Wu L,Chen X,Hao Y,Wang Z,Wang X,Ouyang W,Kalady MF,Carman J,?Yang WP,Zhu J, Blackburn C Huang YH, Hamilton TA1,Su B, LiX. IL-17A-Induced PLET1 Expression Contributes to Tissue?Repair and Colon J Immunol. 2017 199(11):3849-3857.
Greenblatt MB, Shin DY, Oh H, Lee KY, Zhai B, Gygi SP, Lotinun S, Baron R, Liu D, Su B, Glimcher LH, Shim JH MEKK2 mediates an alternative β-catenin pathway that promotes bone formation Proc Natl Acad Sci U S A 2016 113(9):E1226-35
Wang Q, Tan R, Zhu X, Zhang Y, Tan Z, Su B （通讯作者）, Li Y Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression Oncotarget 2016 7(9):10064-72
Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B （通讯作者） Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex Nature Communications 2015 6:7937
Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C. Cantley, Alex Toker, Su B （通讯作者）, Wenyi Wei PtdIns(3,4,5)P3-dependent activation of the mTORC2 kinase complex Cancer Discov 2015 5 (11): 1194-209
Kaur S, Kroczynska B, Sharma B, Sassano A, Arslan AD, Majchrzak-Kita B, Stein BL, McMahon B, Altman JK, Su B, Calogero RA, Fish EN, Platanias LC Critical roles for Rictor/Sin1 complexes in IFN-dependent gene transcription and generation of antiproliferative responses J Biol Chem 2014 289(10):6581-91
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis Nat Cell Biol 2013 15(11):1340-50
Zhou XT, Chen DN, Xie ZQ, Peng Z, Xia KD, Liu HD, Liu W, Su B, Li JD. Functional analysis of the distal region of the third intracellular loop of PROKR2 Biochem Biophys Res Commun 2013 439(1):12-7
Fan Zhang, Adam Lazorchak, Dou Liu, Fanping Chen, Su B （通讯作者） Inhibition of the mTORC2 and chaperone pathways to treat leukemia Blood 2012 119(25):6080-8
Xing Chang, Adam S. Lazorchak, Dou Liu, Su B （通讯作者） Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation Eur J Immunol 2012 42(6):1639-47
Xiaofang Wang, Fan Zhang, Fanping Chen, Dou Liu, Yi Zheng, Yongliang Zhang, Chen Dong, Su B （通讯作者） MEKK3 regulates IFNg production in T cells through the Rac1/2 dependent MAPK cascades J Immunol 2011 186:5791-5800
Su B （通讯作者）, Estela Jacinto Mammalian TOR signaling to the AGC kinases Crit Rev Biochem Mol Biol 2011 46(6):527-47
Adam S. Lazorchak, Su B （通讯作者） Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis Protein & Cell 2011 2(7):523-530
Xing Chang, Fang Liu, Xiaofang Wang, Su B （通讯作者） MEKK2 and MEKK3 regulate TGF-b-mediated helper T cell differentiation Immunity 2011 34:201-212
You-Tong Wu, Weiming Ouyang, Adam S Lazorchak, Dou Liu, Han-Ming Shen, Su B （通讯作者） mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif J Biol Chem 2011 286:14190-14198
Adam S Lazorchak, Dou Liu, Valeria Facchinetti, Annarita Di Lorenzo, William C Sessa, David G Schatz, Su B （通讯作者） Sin1 suppresses rag1/2 and il7r gene expression through Akt2 in B cells Mol Cell 2010 39:433-443
Xiaofang Wang, Yongliang Zhang, Valeria Facchinetti, Yuan Zhuang, Su B （通讯作者） MEKK3 Is Essential for Lymphopenia-Induced T cell Proliferation and Survival J Immunol 2009 182(6):3597-3608
Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C. Newton, Yuxin Mao, Robert Q. Miao, William C. Sessa, Jun Qin, Pumin Zhang, Su B （通讯作者）, Estela Jacinto The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C EMBO J 2008 27(14):1932-43
Kihwan Kim, Omar Duramad, Xiaofeng Qin and Su B. MEKK3 is essential for lipopolysaccharide-induced il-6 and gm-csf production in macrophages. Immunology. 2007 120(2):242-50
Dongyu Zhang, Valeria Fachinnetti, Xiaofang Wang, Qiaojia Huang, Jun Qin, Su B （通讯作者） Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor- and stress-pathways EMBO J 2006 25:97-107
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B （通讯作者） SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006 127(1):125-3
Jinke Cheng, Dongyu Zhang, Kihwan Kim, Yingxin Zhao, Yingming Zhao, Su B （通讯作者） Mip1, an MEKK2 interacting protein, regulates MEKK2 dimerization and activation Mol Cell Biol 2005 25(14):5955-5964
Jinke Cheng, Ling Yu, Dongyu Zhang, Qiaojia Huang, David Spencer, Su B （通讯作者） Dimerization through the catalytic domain is essential for MEKK2 activation J. Biol. Chem. 2005 280:13477-82
Jinke Cheng, Ling Yu, Dongyu Zhang, Qiaojia Huang, David Spencer, Su B. （通讯作者） Dimerization through the catalytic domain is essential for MEKK2 activation. J. Biol. Chem 2005 280:13477-82
Qiaojia Hunag, Jianhua Yang, Jinke Cheng, CM Walker, Z.G. Liu, Su B. （通讯作者） Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3. Nature Immunology 2004 5:95-103
Zijian Guo, Gavin Clydesdale, Jinke Cheng, Kihwan Kim, Lin Gan, David J. McConkey, Stephen E. Ullrich, Yuan Zhuang*, Bing Su （通讯作者） Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-Cell receptor signal transduction Mol Cell Biol 2002 22(16):5761-5768
Xu X, Su B., Barndt RJ, Chen H, Xin H, Yan G, Chen L, Cheng D, Heitman J, Zhuang Y, Fleischer S, Shou W. FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506. Transplantation 2002 Jun 15;73(11):1835-8
Su B （通讯作者）, Cheng JK, Yang J MEKK2 mediates T cell co-stimulation of the JNK cascade and IL-2 gene expression J Biol Chem 2001 276:14784-90
Yang J, Lin Y, Guo Z, Cheng J, Huang H, Liao W, Chen Z, Liu Z, Su B （通讯作者） The essential role of MEKK3 in TNF-induced NF-kB activation Nature Immunology 2001 2:620-624
Cheng J, Yang J, Xia Y, Karin, M., and Su B. （通讯作者） Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol 2000 20(7):2334-2341
Xia Y, Makris C, Su B., Li EG, Yang JH, Nemerow GR, Karin M. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. PNAS 2000 97(10): 5243-5248
Yang J, Boerm M, McCarty M, Bucana C, Fidler J, Zhuang Y, Su B （通讯作者） Essential role of MEKK3 in early embryonic cardiovascular development Nature Genetics 2000 24:309-313
Lee H, Jiang F, Wang Q, Nicosia SV, Yang J, Su B., Bai W. MEKK1 activation of human Estrogen receptor a and stimulation of the agonisttic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells. Molecular Endocrinology 2000 14(11):1882-96
Dong Z, Killion JJ, Kumar R, Eue I, Yang X, Lu W, Su B., Fidler IJ. Activation of cytokine production, tumoricidal properties, and tyrosine phosphorylation of MAPKs in human monocytes by a new synthetic lipopeptide, JBT3002 J Leukocyte Biol 1998 63(6):766-774
Wang Y, Su B., Sah VP, Brown JH, Han J, Chien KR. Cardiac hypertrophy induced by Mitogen-activated Protein Kinase Kinase , a specific activator for c-jun NH2-terminal kinase in ventricular muscle cells. J. Biol. Chem. 1998 273:5423-5426
Xia Y, Wu Z, Su B., Murray B, and Karin, M. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components: MEKK1 and JNK. J Leukocyte Bio 1998 63(6):766-774,
Xia Y, Wu Z, Su B., Murray B, and Karin, M. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components: MEKK1 and JNK. Genes & Dev 1998 12(21):3369-3381
Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. Shear stress activates both JNK and Erk kinase pathways. Mole. Mole. Cell. Biol. 1996 16:5947-5954
Cavigelli M, Dolfi F, Su B, Yoshioka K and Karin M The tumor promoter arsenite stimulates AP-1 activity through inhibition of a JNK phosphatase. EMBO J 1996 15:6269-6279
Derijard, B., Hibi, M., Wu, I-Huan, Barrett, T., Su B., Deng, T., Karin, M., and Davis, R.J JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphrylates the cJun activation domain Cell 1994 76:1025-1037
Lee, S., Su B. （共同第一作者）, Maher, S., and Bothwell, A.L.M. Ly6A is required for antigen-specific response and expression of T cell receptor EMBO J 1994 13:2167-2176
Su B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y JNK mediates signal integration during costimulation of T lymphocytes Cell 1994 77:727-736
Su B., Waneck, G.L., Flavell, R.A. and Bothwell, A.L.M. The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E mediated T cell activation. J. Cell Biol. 1991 2.112:337-384
Su B, Bothwell, A.L.M Biosynthesis of a phosphatidylinositol-glycan-linked membrane protein: signals for posttranslational processing of the Ly-6E antigen Mol. Cell. Biol. 1989 9: 3369-3376