导师姓名： 黄雷 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海交通大学医学院组织胚胎学与遗传发育系上海市重庆南路280号5号楼505 室 200025电话：-776576
邮编： 200025 邮箱地址： leihuang@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤遗传学

社会任职
上海病理生理学会理事
黄浦区人大代表
上海交通大学医学院“中青年知识分子联谊会”副会长
美国人类遗传学会会员、中国遗传学会会员、中国细胞生物学学会会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 黏蛋白1调控肿瘤干细胞分裂模式的机制及临床意义研究 国家自然科学基金面上项目 2019-01~2022-12 57万元 课题负责人
2015CB910403 代谢应激过程中蛋白质修饰相关的生物标志物和潜在靶点的发现 国家重大研究计划项目 2015-01~2019-12 60万元 课题参与人
** MUC1在产后乳腺退化中的作用及其与TNBC发病的关系研究 国家自然科学基金面上项目 2015-01~2018-12 72万元 课题负责人
** MUC1在肺癌早期发生和转移中的作用和机制研究 国家自然科学基金面上项目 2013-01~2016-12 80万元 课题负责人
2012CB967000 肿瘤干细胞的动态演进及干预研究 国家重大研究计划项目 2012-01~2016-12 92万元 课题参与人
乳腺癌小鼠模型的建立及肿瘤发生机制研究 上海市科委实验动物研究项目 2011-12~2013-09 20万元 课题负责人
** MDMX基因定点诱变小鼠模型的建立及其生物学功能研究 国家自然科学基金面上项目 2011-01~2013-12 35万元 课题负责人
NCET-08-0349 MUC1在肺癌治疗中的作用及其机制研究 教育部“新世纪优秀人才支持计划 2009-01~2011-12 50万元 课题负责人
** MUC1在乳腺癌治疗中的作用及其机制研究 国家自然科学基金面上项目 2009-01~2011-12 35万元 课题负责人
07pj14065 MUC1在肺癌发病和治疗中的作用及其机制研究 上海市科委“浦江人才计划” 2007-09~2009-09 20万元 课题负责人
** MUC1过度表达小鼠模型的建立及其致瘤机制研究 国家自然科学基金面上项目 2007-01~2009-12 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wu AY, Gu LY, Cang W, Cheng MX, Wang WJ, Di W, Huang L （通讯作者）, Qiu LH. Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation. J Exp Clin Cancer Res. 2019 38 (1):176.
Wang Y, Liao X, Ye Q, Huang L （通讯作者） Clinic implication of MUC1 O-glycosylation and C1GALT1 in esophagus squamous cell carcinoma. Sci China Life Sci. 2018 61(11):1389-1395.
Gamze Kuser-Abali, Lu Gong, Jiawei Yan, Qingqing Liu, Weiqi Zeng, Amanda Williamson, Chuan Bian Lim, Mary Ellen Molloy, John B. Little, Lei Huang, Zhi-Min Yuan. An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage. Proc Natl Acad Sci U S A. 2018 115(13):3452-3457.
Yuan Li, Zhi Pang, Xinran Dong, Xiaodong Liao, Huayun Deng, Chunhua Liao, Yahui Liao, Guoqiang Chen, Lei Huang. （通讯作者） MUC1 induces M2 type macrophage influx during postpartum mammary gland involution and triggers breast cancer. Oncotarget. 2018 9 (3): 3446-3458
Hu Y, Li D, Wu A, Qiu X, Di W, Huang L （通讯作者）, Qiu L. TWEAK-stimulated macrophages inhibit metastasis of epithelial ovarian cancer via exosomal shuttling of microRNA. Cancer Lett. 2017 393:60-67.
Fu RJ, He W, Wang XB, Li L, Zhao HB, Liu XY, Pang Z, Chen GQ, Huang L* （通讯作者）, Zhao KW*. DNMT1-mediated hypermethylation of Krüppel-like factor 5 regulates the progression of clear cell renal cell carcinoma. Cell Death & Disease 2017 8(7):e2952.
Jin W, Liao X, Lv Y, Pang Z, Wang Y, Li Q, Liao Y, Ye Q, Chen G, Zhao K*, Huang L*. （通讯作者） MUC1 induces acquired chemoresistance by upregulating ABCB1 in EGFR-dependent manner. Cell Death & Disease 2017 8(8):e2980
Zhao XY, Li L, Wang XB, Fu RJ, Lv YP, Jin W, Meng C, Chen GQ, Huang L （通讯作者）, Zhao KW. Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells. PLoS ONE. 2016 11(10):e**.
Wang Y, Shang W, Lei X, Shen S, Zhang H, Wang Z, Huang L, Yu Z, Ong H, Yin X, Yang W, Zhang C. Opposing functions of PLAG1 in pleomorphic adenoma: a microarray analysis of PLAG1 transgenic mice Biotechnol Lett 2013 35(9):1377-85
Wang F, Wang PX, Wu XL, Dang SY, Chen Y, Ni YY, Gao LH, Lu SY, Kuang Y, Huang L, Fei J, Wang ZG, Pang XF. Deficiency of Adiponectin Protects against Ovariectomy-Induced Osteoporosis in Mice. PLoS One 2013 8(7):e68497.
Xu WY, Gu MM, Sun LH, Guo WT, Zhu HB, Ma JF, Yuan WT, Kuang Y, Ji BJ, Wu XL, Chen Y, Zhang HX, Sun FT, Huang W, Huang L, Chen SD, Wang ZG. A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree. Am J Hum Genet 2012 91(6):1088-94.
Li Y, Yi H, Yao Y, Liao X, Xie Y, Yang J, Yan Z, Wang L, Lu S, Kuang Y, Gu M, Fei J, Wang Z, Huang L （通讯作者） The Cytoplasmic Domain of MUC1 Induces Hyperplasia in the Mammary Gland and Correlates with Nuclear Accumulation of β-catenin. PLoS ONE 2011 6(4):e19102
Shen S, Yang W, Wang Z, Lei X, Xu L, Wang Y, Wang L, Huang L, Yu Z, Zhang X Li J, Chen Y, Zhao X, Yin X, Zhang C. . Tumor-Initiating Cells Are Enriched in CD44(hi) Population in Murine Salivary Gland Tumor. PLoS ONE. 2011 6(8)
Ye Q, Yan Z, Liao X, Li Y, Yang J, Sun J, Kawano T, Wang X, Cao Z,Wang Z, Huang L （通讯作者） MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13 Lab Invest 2011 91(5):778-87
Huang L （通讯作者）, Yan Z, Liao X, Li Y, Yang J, Wang ZG, Zuo Y, Kawai H, Shadfan M, Ganapathy S, Yuan ZM. The MDM2/MDMX complex is required for control of p53 activity in vivo. Proc Natl Acad Sci U S A. 2011 108(29):12001-6
Shen S, Yang W, Wang Z, Lei X, Xu L, Wang Y, Wang L, Huang L, Yu Z, Zhang X Li J, Chen Y, Zhao X, Yin X, Zhang C. . Tumor-Initiating Cells Are Enriched in CD44(hi) Population in Murine Salivary Gland Tumor. PLoS ONE. 2011 6(8)
Huang L, Liao X., Beckett M., Li Y., Khanna K. K., Wang Z., Kharbanda S., Weichselbaum R. and Kufe D. MUC1 Oncoprotein Interacts Directly With ATM and Promotes the DNA Damage Response to Ionizing Radiation. Genes & Cancer. 2010 1(3):239-250
Macdermed DM, Khodarev NN, Pitroda SP, Edwards DC, Pelizzari CA, Huang L, Kufe DW, Weichselbaum RR. MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients. BMC Med Genomics. 2010 3(1):16.1-12
Khodarev NN, Pitroda SP, Beckett MA, Macdermed DM, Huang L, Kufe DW, Weichselbaum RR. MUC1-Induced Transcriptional Programs Associated with Tumorigenesis Predict Outcome in Breast and Lung. Cancer Res. 2009 69(7):2833-7
Wu XL, Gu MM, Huang L, Liu XS, Zhang HX, Ding XY, Xu JQ, Cui B, Wang L, Lu SY, Chen XY, Zhang HG, Huang W, Yuan WT, Yang JM, Gu Q, Fei J, Chen Z, Yuan ZM, Wang ZG. Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. Am J Hum Genet. 2009 85(1):53-63.
Leng Y, Cao C, Ren J, Huang L, Chen D, Kufe D. Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62. J Biol Chem. 2007 282(27):19321-30
Ren J, Raina D, Chen W, Li G, Huang L, Kufe D. MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signaling. Mol Cancer Res. 2006 4(11):873-83.
Huang L, Chen D., Liu D, Yin L, Kharbanda S, Kufe D. MUC1 Oncoprotein Blocks Glycogen Synthasa Kinase 3β-Mediated Phosphorylation and Degradation of β-catenin. Cancer Research. 2005 65(22) :10413-10422
Ren J, Agata N, Chen D, Li Y, Yu WH, Huang L, Raina D, Chen W, Kharbanda S, Kufe D. Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. Cancer Cell. 2004 5(2):163-75.
Yin L, Huang L, Kufe D. MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress. J Biol Chem. 2004 279(44):45721-7
Huang L, Ren J, Chen D, Li Y, Kharbanda S, Kufe D. MUC1 Cytoplasmic Domain Coactivates Wnt Target Gene Transcription and Confers Transformation. Cancer Biol Ther. 2003 2(6):702-706.