导师姓名： 吴英理 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市重庆南路280号2号楼805
邮编： 200025 邮箱地址： wuyingli@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤细胞的靶标识别和靶向干预

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2017YFA** 蛋白质机器的外源小分子标记与动态调控 国家蛋白质机器与生命过程调控重点专项 2017-07~2022-07 230万元 课题参与人
** USP47在慢性粒细胞性白血病发病和治疗中的作用和机制 国家自然科学基金 2016-01~2019-12 60万元 课题负责人
P2015-KF05 益母草中抗白血病活性化合物的发现和机理研究 ?植物化学与西部植物资源持续利用国家重点实验室开放课题 2015-06~2018-06 8万元 课题负责人
2015CB910403 代谢应激和肿瘤发生发展中蛋白质修饰 动态调控及生理病理效应。 国家重点基础研究发展计划，项目号为。起止年月：2015，01-2018，12。 2015-01~2018-12 60万元 课题参与人
** 细胞可塑性调控信号转导的化学生物学研究 ?国家自然科学基金重大研究计划集成项目。项目号为。起止年月：2014.1-2015.12。经费：90 2014-01~2015-12 90万元 课题参与人
** 转录因子Ikaros在卵巢癌上皮-间质转化过程中的作用及机制研究。 国家自然科学基金 2013-01~2016-12 68万元 课题负责人
11JC** 应用小分子探针腺花素揭示peroxiredoxin在白血病细胞分化中的作用及机制。 上海市科委重点基础研究基金 2012-01~2014-12 25万元 主要责任人
** 腺花素诱导白血病细胞分化的分子机制 国家自然科学基金 2011-01~2013-12 34万元 主要责任人
** 利用小分子se2研究以SENP1为中心的SUMO化修饰信号转导网络 国家自然科学基金重大研究计划培育项目 2011-01~2013-12 50万元 主要责任人
** 酸性富亮氨酸核磷酸蛋白32B在细胞凋亡中的作用及其机制 国家自然基金委,面上项目 2009-01~2011-12 32万元 课题负责人
05QMX1425 低氧及模拟低氧诱导分化治疗白血病模型小鼠 上海市科委,启明星 2005-09~2007-12 10万元 课题负责人
** 低氧诱导因子-1调控物诱导分化治疗白血病的实验研究 国家自然基金委,面上项目 2005-01~2007-12 21万元 课题负责人
08JC** 腺花素联合维生素D3诱导白血病细胞分化效应及机制研究 上海市科委，基础重点项目 ~2010-09 30万元

学术论文 作者论文标题期刊名出版年卷期页码
Luo Hao, Jing B, Lei H, Xu HZ, Zhou L, Liu W, Tong Y, Wu YL. （通讯作者） WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia Cancer Cell Int 2019 19:56
Tong J, Xu X, Zhang ZL, Ma CN, Xiang RF, Liu J, Xu WB, Wu C, Li JM, Zhan FH, Wu YL （通讯作者）, Yan H. Hypoxia-induced long non-coding RNA DARS-AS1 regulates RBM39 stability to promote myeloma malignancy Hematologica 2019 Jul 9
Tong J, Yu Q, Xu W, Yu W, Wu C, Wu YL （通讯作者）, Yan H. Montelukast enhances cytocidal effects of carfilzomib in multiple myeloma by inhibiting mTOR pathway Cancer Biol Ther 2019 20(3):381-390
Yang L, Song LL, Zhao S, Ma CM, Wu DP, Wu YL. （通讯作者） Isobavachalcone reveals novel characteristics of methuosis-like cell death in leukemia cells. Chemica-Biological interaction 2019 304:131-138
Hu J, Shen W, Qu Q, Fei X, Miao Y, Huang X, Liu J, Wu Y （通讯作者）, Li B. NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition. Front Med. 2019 May 22
Wang WW, Li XY, Wang ZH, Zhang JF, Dong X, Wu YZ, Fang C, Zhou AW, Wu YL. （通讯作者） A novel “mosaic-type” nanoparticle for selective drug-release targeting hypoxia cancer cells. Nanoscale 2019 11(5):2211-2222
Lei H, Tu Y, Yang L, Jin J, Luo H, Xu H, Kang J, Zhou L, Wu YL. （通讯作者） Quinacrine Depletes BCR-ABL and Suppresses Ph-Positive Leukemia Cells Cancer Investigation 2019 11:1-11
Wu K, Yu X, Huang Z, Zhu D, Yi X, Wu YL, Hao Q, Kemp KT 2nd, Elshimali Y, Iyer R, Nguyen KT, Zheng S, Chen G, Chen QH, Wang G, Vadgama JV, Wu Y. Targeting of PP2Cδ By a Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer Progression In Vivo Antioxid Redox Signal 2018 30(17):1983-1998
Lei H,Yang L,Zhou L,Tong Y,Wu YL （通讯作者） Targeting acute myeloid leukemia CD34+ stem/progenitor cells with small molecule inhibitor MK-8776 Leukemia Research 2018 72:71-73
XU Han-Zhang, Wang Zhuo-Qun, Shan Huizhuang, Zhou Li, Yang Li, Lei Hu, LIU Bin, Wu YL. （通讯作者） Overexpression of Fbxo6 inactivates spindle checkpoint by interacting with Mad2 and BubR1. Cell cycle 2018 17(24):2779-2789
Jing B, Jin J, Xiang RF, Liu M, Yang L, Tong Y, Xiao XH, Liu W, Lei H, Xu HZ, Deng J, Zhou L, Wu YL. （通讯作者） Vorinostat and quinacrine synergistically induce cell death in T-cell leukemia through reactive oxygen species increase and mitophagy inhibition. Cell Death Disease 2018 9(6):589
Wang YY, Wu LL, Cai HY, Ma CM, Lei H, Yang L, Xu HZ, Zhu Q, Yao ZJ, Wu YL. （通讯作者） Sinomenine derivative YL064: a novel STAT3 inhibitor with promising anti-myeloma activity. Cell Death Disease 2018 9(11):1093
Yin LM, Xu YD, Peng LL, Duan TT, Liu JY, Xu ZJ, Wang WQ, Guan N, Han XJ, Li HY, Pang Y, Wang Y, Chen ZQ, Zhu WL, Deng LH, Wu YL, Ge GB, Huang S, Ulloa L, Yang YQ. Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance. Sci Transl Med. 2018 10(427)
Yue ZW, Xiao XH, Wu JB, Zhou XZ, Liu WL, Liu YX, Li HH, Chen GQ, Wu YL （通讯作者）, Lei XG. Ent-Jungermannenone C Triggers Reactive Oxygen Species-Dependent Cell Differentiation in Leukemia Cells. J Nat Prod. 2018 81(2):298-306
Yang ZY, Li C, Yan C, Li JF, Yan M, Liu BY, Zhu ZG, Wu YL （通讯作者）, Gu QL. KIF14 promotes tumor progression and metastasis and is an independent predictor of poor prognosis in human gastric cancer BBA - Molecular Basis of Disease 2018 1865(1):181-192
Shan HZ, Li XY, Xiao XH, Dai YT, Huang JY, Liu M, Yang L, Lei H, Tong Y, Zhou L, Xu HZ, Wu YL （通讯作者） USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia. Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy 2018 3：29
Wang YY, Wu LL, Cai HY, Ma CM, Lei H, Yang L, Xu HZ, Zhu Q, Yao ZJ, Wu YL. （通讯作者） YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells. Cell death discovery 2018 5: 44
Xiao XH, Jin HZ, J Jin, Ma CM, T Yin, Zhou L, Lei H, Xu HZ, Liu W*, Wu YL* （通讯作者） 11(13)-dehydroivaxillin suppresses NF-?B activation in Non-Hodgkin's lymphoma cells by targeting IKKα/β. Cell Death Disease 2017 8(9):e3050
Jing B, Liu M, Yang L, Cai HY, Chen JB, Li ZX, Kou X, Wu YZ, Qin DJ, Zhou L, Jin J, Lei H, Xu HZ, Wang WW, Wu YL*. （通讯作者） Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Deubiquitinating Proteases USP7 Acta Pharmacologica Sinica 2017 39(3):492-498
Wei W, Ma CM, Cao Y, Yang L, Huang Z, Qin DJ, Chen Y, Liu CX, Xia L, Lei H, Yu Y, Huang M, Tong Y, Xu HZ, Gao FH, Zhang J, Wu YL （通讯作者） Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells Oncotarget 2016 7(4):3873-3783
Masoumi K, Marfany G, Wu YL, Massoumi R. The activation of deubiquitination enzymes is controlled by SUMOylation in cancer. Future Oncology 2016 12(4):565-574
Xu Y, Liu JB, Wu YL, Guo QL, Sun HD, Chen GQ. Natural products against hematological malignancies and identification of their targets. Sci. China Life Sci 2015 58: 1–11
Hu JJ, Lei H, Fei XC, Liang S, Xu HZ, Qin DJ, Wang Y, Wu YL （通讯作者）, Li B NES1/KLK10 gene represses proliferation, enhances apoptosis and down-regulates glucose metabolism of PC3 prostate cancer cells. Scientific report 2015 5:17426
CaoY, Wei W, Zhang N, Yu Q , Xu WB, Chen GQ, Wu YL （通讯作者）, Yan H. Oridonin Stabilizes Retinoic Acid Receptor alpha through ROS-activated NF-kappa B signaling. BMC Cancer 2015 15(1):248
Dong-Jun Qin, Cai-Xia Tang, Li Yang, Hu Lei, Wei Wei, Ying-Ying Wang, Chun-Min Ma, Feng-Hou Gao, Han-Zhang Xu, Ying-Li Wu*. （通讯作者） Hsp90 is a novel target of CDDO-ME in inducing cell death of ovarian cancer cells. Plos One 2015 10(7):e**
Song LL, Tu YY, Xia L, Wang WW, Wei W, Ma CM, Wen DH, Lei H, Xu HZ, Wu YL. （通讯作者） Targeting Catalase but not Peroxiredoxins Enhances Arsenic Trioxide-induced Apoptosis in K562 Cells. Plos One 2014 9(8):e104985
Zhang Yue, Zhao FJ, Chen LL, Wang LQ, Nephew K, Wu YL （通讯作者）, Zhang S. MiR-373 Targeting of the Rab22a Oncogene Suppresses Tumor Invasion and Metastasis in Ovarian Cancer. Oncotarget 2014 5(23):12291-303
Wen D, Xu Z, Xia L, Liu X, Tu Y, Lei H, Wang W, Wang TD, Song L, Ma C, Xu H, Zhu W, Chen GQ, Wu YL*. （通讯作者） Important role of SUMOylation of spliceosome Factors in prostate cancer cells. J Proteome Res 2014 13(8):3571-82
Huang H, Cao Y, Wei W, Liu W, Lu SY, Chen YB, Wang Y, Yan H, Wu YL*. （通讯作者） Targeting Poly (ADP-ribose) polymerase Partially Contributes to Bufalin-induced Cell Death in Multiple Myeloma Cells. Plos One 2013 8(6):e66130
Yin QQ, Liu CX, Wu YL, Wu SF, Wang Y, Zhang X, Hu XJ, Pu JX, Lu Y, Zhou HC, Wang HL, Nie H, Sun HD, Chen GQ. Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling. J Immunol 2013 191(5):2115-25
Yang ZY, Jiang H, Qu Y, Wei Min, Min Yan, Zhu ZG, Liu BY, Chen GQ, Wu YL* （通讯作者）, Gu QL. Metallopanstimulin-1 Regulates Invasion and Migration of Gastric Cancer Cells Partially Through Integrin β4. Carcinogenesis 2013 34(12):2851-60
Wei W, Huang H, Zhao S, Liu W, Liu CX, Li C, Li JM, Wu YL* （通讯作者）, Yan H. Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib through NF-κB inhibition and Bcr/Abl protein deletion. Apoptosis 2013 18(9) ,1060-1070
He LC, Gao FH, Xu HZ, Zhao S, Ma CM, Li JE, Zhang S, Wu YL*. （通讯作者） Ikaros inhibits proliferation and, through upregualtion of Slug, increases metastatic ability of ovarian serous adenocarcinoma cells. Oncology reports 2012 28(4):1399-405
Gao FH #, Liu F #, Wei W, Liu LB, Xu MH, Guo ZY, Li W, Jiang B, Wu YL*. （通讯作者） Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathion depletion in colorectal cancer cells. Int J Mol Med 2012 29(4):649-655
Zhao S, Ma CM, Liu CX, Wei W, Liu B, Xu HZ, He LC, Yan Hua, Wu YL*. （通讯作者） Autophagy inhibition enhances isobavachalcone induced cell death in multiple myeloma cells. Int J Mol Med 2012 Jul 16:1-6
Liu B, Zheng Y, Wang TD, Xu HZ, Xia L, Wu YL, Chen GQ, Wang LS. Proteomic Identification of Common SCF Ubiquitin Ligase FBXO6-Interacting Glycoproteins in Three kinds of Cells. J Proteome Res 2012 11(3):1773-81
Liu CX, Yin QQ, Zhou HC, Wu YL （通讯作者）, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zha Q, Zhou AW, Wang LS, Sun HD, Chen GQ. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nature Chemical Biology 2012 8(5):486-93
He LC, Xu HZ, Gu ZM, Liu CX, Chen GQ, Wang YF, Wen DH, Wu YL. （通讯作者） Ikaros is degraded by proteasome-dependent mechanism in the early phase of apoptosis induction. Biochem Biophys Res Commun. 2011 406(3):430-4
Yang ZY,Qu Y, Zhang Q, Wei M, Liu CX, Chen XH, Yan M, Zhu ZG, Liu BY, Chen GQ, Wu YL* （通讯作者）, Gu QL*. Knockdown of Metallopanstimulin-1 Inhibits NF-κB Signaling at Different Levels: The Role of Apoptosis Induction of Gastric Cancer Cells. Int J Cancer 2011 130(12):2761-70
Qiao ZT, Wang WW, Wang L, Wen DH, Zhao YX, Wang Q, Meng QQ, Chen GQ, Wu YL* （通讯作者）, Zhou HC*. Design, Synthesis, and Biological Evaluation of Benzodiazepine-based SUMO-Specific Protease 1 Inhibitors. Bioorganic & Medicinal Chemistry Letters 2011 21(21):6389-92
Gu ZM, Liu CX, Wu SF, Zhao M, Xu HZ, Zhou HC, Chen GQ, Wu YL. （通讯作者） PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells. FEBS Letters 2011 585(2):375-80
Gao F, Tang Q, Yang P, Fang Y, Li W, Wu YL. （通讯作者） Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells. Int J Lab Hematol. Int J Lab Hematol 2010 32:114-22
Azouz A, Wu YL, Hillion J, Tarkanyi I, Karniguian A, Aradi J, Lanotte M, Chen GQ, Chehna M, Ségal-Bendirdjian E. Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells. Leukemia 2010 24:613-22
Shen SM, Yu Y, Wu YL, Cheng JK, Wang LS, Chen GQ. Down-regulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells. Carcinogenesis 2010 31:419-26
Gao FH, Wu YL （共同第一作者）, Zhao M, Liu CX, Wang LS, Chen GQ. Protein Kinase C-δ mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. Exp Cell Res 2009 315:3250-3258
Zhang R, Wu YL, Zhao M, Liu C, Zhou L, Shen S, Liao S, Yang K, Li Q, Wan H. Role of HIF-1{alpha} in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2009 297:631-40
Yan H, Wang YC, Li D, Wang Y, Liu W, Wu YL, Chen GQ. Arsenic Trioxide and Proteasome Inhibitor Bortezomib Synergistically Induce Apoptosis in Leukemia Cells: the Role of Protein Kinase C?. Leukemia 2007 21:1488-95
Wu YL, Dudognon C, Nguyen E, Hillion J, Pendino F, Tarkanyi I, Aradi J, Lanotte M, Tong JH, Chen GQ, Segal-Bendirdjian E. Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J Cell Sci 2006 119:2797-806
Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood 2006 107:698-707
Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica 2005 90:1607-16
Yin T, Wu YL （共同第一作者）, Sun HP, Sun GL, Du YZ, Wang KK, Zhang J, Chen GQ, Chen SJ, Chen Z. Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein. Blood 2004 104:4219-25.