导师姓名： 童雪梅 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市重庆南路280号西7楼209室电话：E-mail：xuemeitong@shsmu.edu.cn
邮编： 200025 邮箱地址： xuemeitong@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤和代谢性疾病的调控机制

社会任职
上海市黄浦区青年联合会第一届委员会委员
上海市黄浦区青年联合会第二届委员会委员
第三届上海市优秀青年女教师联谊会会员
上海市黄浦区侨联青年委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 转录因子MondoA调控结直肠肿瘤微环境中调节性T细胞代谢和功能的机制研究 国家自然科学基金面上项目 2020-01~2023-12 56万元 课题负责人
** 肝脏特异性敲除转酮醇酶TKT减缓肝癌发生的机制研究 国家自然科学基金面上项目 2017-01~2020-12 50万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH, Tong X （通讯作者） Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides. Cancer Research 2019 79(14):3689-3701
Ran H, Zhu Y, Deng R, Zhang Q, Liu X, Feng M, Zhong J, Lin S, Tong X （通讯作者）, Su Q. Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN. J Exp Clin Cancer Res. 2018 12;37(1):54.
Wang J, Tan M, Ge J, Zhang P, Zhong J, Tao L, Wang Q, Tong X （通讯作者）, Qiu J. Lysosomal acid lipase promotes cholesterol ester metabolism and drives clear cell renal cell carcinoma progression. Cell Prolif. 2018 23:e12452
Mao JY, Sun JT, Yang K, Shen WF, Lu L, Zhang RY, Tong X （通讯作者）, Liu Y. Serum amyloid A enrichment impairs the anti-inflammatory ability of HDL from diabetic nephropathy patients. J Diabetes Complications. 2017 31(10):1538-1543
Meng J, Feng M, Dong W, Zhu Y, Li Y, Zhang P, Wu L, Li M, Lu Y, Chen H, Liu X, Lu Y, Sun H, Tong X （通讯作者） Identification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose. Sci Rep. 2016 6:1-14
Chen H, Wu L, Li Y, Meng J, Lin N, Yang D, Zhu Y, Li X, Li M, Xu Y, Wu Y, Tong X （通讯作者）, Su Q Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation. Mol Cell Endocrinol. 2014 395(1-2):69-78
Wu L, Chen H, Zhu Y, Meng J, Li Y, Li M, Yang D, Zhang P, Feng M, Tong X （通讯作者） Flightless I homolog negatively regulates ChREBP activity in cancer cells. Int J Biochem Cell Biol. 2013 45(11):2688-97.
Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A. 2012 109(18):6904-9
Zhao F, Mancuso A, Bui TV, Tong X, Gruber JJ, Swider CR, Sanchez PV, Lum JJ, Sayed N, Melo JV, Perl AE, Carroll M, Tuttle SW, Thompson CB. Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha- induced metabolic reprogramming. Oncogene. 2010 29(20):2962-72.
Tong X （通讯作者）, Zhao F, Thompson CB. The molecular determinants of de novo nucleotide biosynthesis in cancer cells. Current Opinion in Genetics & Development. 2009 19(1):32-7.
Tong X, Zhao F, Mancuso A, Gruber JJ and Thompson CB. The glucose- responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. Proc Natl Acad Sci U S A. 2009 106(51):21660-5.
Larouche D, Tong X, Fradette J, Coulombe PA, Germain L. Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile. FASEB J. 2008 22(5):1404-15.
Tong X, Coulombe PA. Keratin 17 modulates hair follicle cycling in a TNFalpha- dependent fashion. Genes & Development 2006 20(10):1353-64.
Tong X, Coulombe PA. A novel mouse type I intermediate filament gene, keratin 17n (K17n), exhibits preferred expression in nail tissue. Journal of Investigative Dermatology 2004 122(4):965-70.
Tong X, Coulombe PA. Mouse models of alopecia: identifying structural genes that are baldly needed. Trends in Molecular Medicine 2003 9(2):79-84.
McGowan KW, Tong X （共同第一作者）, Colucci-Guyon E, Langa F, Babinet C, Coulombe PA. Keratin 17 null mice exhibit age- and strain-dependent alopecia. Genes & Development 2002 16(11):1412-22.