导师姓名： 覃文新 专业代码： 100214
性别： 男 专业名称： 肿瘤学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： wqin@shsci.org

研究方向 (点击浏览详细信息)
肿瘤个体化治疗
肿瘤发生发展的分子机制
肿瘤标志物与肿瘤早期诊断

社会任职
中国转化医学联盟理事
ISPDC会员
中国抗癌协会肿瘤病因学专业委员会常务委员
中国抗癌协会肿瘤微环境专业委员会常务委员
中国人类蛋白质组委员会理事

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
基于诱导肿瘤细胞衰老的肝癌治疗新策略研究 国家自然科学基金重点国际合作项目 2020-01~2024-12 297.6万元 课题负责人
** Hsa_circ_**作为竞争性内源RNA在肺鳞癌发生发展中的作用及调控机制 国家自然科学基金 2018-01~2021-12 78万元 课题负责人
2018ZX**-002-003 肝癌新标志物DKK1等在肝癌早期诊断中的应用研究 国家科技重大专项 2018-01~2020-12 207.98万元 子课题负责人
** 肠稳态影响慢性重大肠肝疾病的发生与预防 国家自然基金创新群体 2015-01~2020-12 1200万元 子课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yu C#, Cheng Z#, Cui S#, Mao X, Li B, Fu Y, Wang H, Jin H, Ye Q, Zhao X, Jiang L*, Qin W* （通讯作者） circFOXM1 promotes proliferation of non-small cell lung carcinoma cells by acting as a ceRNA to upregulate FAM83D. J Exp Clin Cancer Res 2020 Mar 30;39(1):55
Yang C#, Huang X#, Liu Z#, Qin W* （通讯作者）, Wang C*. Metabolism-associated molecular classification of hepatocellular carcinoma. Mol Oncol 2020 Apr;14(4):896-913
Wang C#, Wang H#, Lieftink C#, du Chatinier A#, Gao D, Jin G, Jin H, Beijersbergen RL, Qin W* （通讯作者）, Bernards R*. CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma Gut 2020 Apr;69(4):727-736
Zuo Q#, He J#, Zhang S#, Wang H, Jin G, Jin H, Cheng Z, Tao X, Yu C, Li B, Yang C, Wang S, Lv Y, Zhao F, Yao M, Cong W, Wang C*, Qin W*. （通讯作者） PGC1α suppresses metastasis of HCC by inhibiting Warburg effect via PPARγ-dependent WNT/β-catenin/PDK1 axis Hepatology. 2020 Apr 16. doi: 10.1002/hep.31280
Cheng Z#, Yu C#, Cui S#, Wang H, Jin H, Wang C, Li B, Qin M, Yang C, He J, Zuo Q, Wang S, Liu J, Ye W, Lv Y, Zhao F, Yao M, Jiang L*, Qin W* （通讯作者） circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1. Nat Commun. 2019 Jul 19;10(1):3200
Wang C#, Vegna S#, Jin H#, Benedict B#, Lieftink C, Ramirez C, de Oliveira RL, Morris B, Gadiot J, Wang W, du Chatinier A, Wang L, Gao D, Evers B, Jin G, Xue Z, Schepers A, Jochems F, Sanchez AM, Mainardi S, Te Riele H, Beijersbergen RL, Qin W* （通讯作者）, Akkari L*, Bernards R* Inducing and exploiting vulnerabilities for the treatment of liver cancer Nature 2019 Oct;574(7777):268-272
Wu H#, Wang C#, Sun J#, Sun L, Wan J, Wang S, Gu D, Yu C, Yang C, He J, Zhang Z, Lv Y, Wang H, Yao M, Qin W* （通讯作者）, Wang C*, Jin H*. Self-Assembled and Self-Monitored Sorafenib/Indocyanine Green Nanodrug with Synergistic Antitumor Activity Mediated by Hyperthermia and Reactive Oxygen Species-Induced Apoptosis. ACS Appl Mater Interfaces. 2019 Nov 27;11(47):43996-44006
Wang H, Liang L, Dong Q, Huan L, He J, Li B, Yang C, Jin H, Wei L, Yu C, Zhao F, Li J, Yao M, Qin W* （通讯作者）, Qin L*, He X* Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in hepatocellular carcinoma Theranostics 2018 8(10):2814-2829
Fan S, Wang Y, Wang C, Jin H, Wu Z, Lu J, Zhang Z, Sun C, Shan Q, Wu D, Zhuang J, Sheng N, Xie Y, Li M, Hu B, Fang J, Zheng Y*, Qin W* （通讯作者） Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance Free Radic Biol Med 2018 120:330-341
Wang C, Jin H, Gao D, Wang L, Evers B, Xue Z, Jin G, Lieftink C, Beijersbergen RL, Qin W* （通讯作者）, Bernards R* A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma Cell Res 2018 28(6):690-692
Wang C, Jin H, Gao D, Lieftink C, Evers B, Jin G, Xue Z, Wang L, Beijersbergen RL, Qin W* （通讯作者）, Bernards R* phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer J Hepatol 2018 Nov; 69(5):1057-1065
Yang J, Wang C, Zhao F, Luo X, Qin M, Arunachalam E, Ge Z, Wang N, Deng X, Jin G, Cong W, Qin W* （通讯作者） Loss of FBP1 facilitates aggressive features of hepatocellular carcinoma cells through the Warburg effect Carcinogenesis 2017 38(2):134-143
Ruan HY, Yang C, Tao XM, He J, Wang T, Wang H, Wang C, Jin GZ, Jin HJ*, Qin WX* （通讯作者） Downregulation of ACSM3 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma Am J Cancer Res 2017 7(3):543-553
Wang H, Huo X, Yang XR, He J, Cheng L, Wang N, Deng X, Jin H, Wang N, Wang C, Zhao F, Fang J, Yao M, Fan J, Qin W* （通讯作者） STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4 Mol Cancer 2017 16(1):136
Jin H, Wang C, Jin G, Ruan H, Gu D, Wei L, Wang H, Wang N, Arunachalam E, Zhang Y, Deng X, Yang C, Xiong Y, Feng H, Yao M, Fang J, Gu J, Cong W, Qin W* （通讯作者） Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1 Gastroenterology 2017 153(3):799-811
Lv X, Zhao F, Huo X, Tang W, Hu B, Gong X, Yang J, Shen Q, Qin W* （通讯作者） Neuropeptide Y1 receptor inhibits cell growth through inactivating mitogen-activated protein kinase signal pathway in human hepatocellular carcinoma Med Oncol 2016 33(7):70
Wang C#, Jin H#, Wang N#, Fan S#, Wang Y, Zhang Y, Wei L, Tao X, Gu D, Zhao F, Fang J, Yao M, Qin W* （通讯作者） Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3β/β-catenin Signaling Theranostics 2016 6(8): 1205–1219
Qin M#, Liu G#, Huo X, Tao X, Sun X, Ge Z, Yang J, Fan J, Liu L*, Qin W* （通讯作者） Hsa_circ_**: A circular RNA and potential novel biomarker for hepatocellular carcinoma Cancer Biomark 2016 16(1):161-9
Wang C#, Zhang Y#, Guo K#, Wang N, Jin H, Liu Y*, Qin W* （通讯作者） Heat shock proteins in hepatocellular carcinoma: Molecular mechanism and therapeutic potential Int J Cancer 2016 138(8):1824-34
Gu D#, Jin H#, Jin G, Wang C, Wang N, Hu F, Luo Q, Chu W, Yao M, Qin W* （通讯作者） The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity Cancer Lett 2016 379(1):107-116
Hu F, Deng X, Yang X, Jin H, Gu D, Lv X, Wang C, Zhang Y, Huo X, Shen Q, Luo Q, Zhao F, Ge T, Zhao F, Chu W, Shu H, Yao M, Fan J*, Qin W*. （通讯作者） Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma. Oncogene 2015 34(49):6007-17(论著，通讯作者，IF=8.459)
Luo Q, Wang C, Jin G, Gu D, Wang N, Song J, Jin H, Hu F, Zhang Y, Ge T, Huo X, Chu W, Shu H, Fang J, Yao M, Gu J, Cong W*, Qin W*. （通讯作者） LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negatively regulating phosphoinositide 3-kinase/AKT pathway. Carcinogenesis. 2015 36(10):1201-12(论著，通讯作者，IF=5.334)
Wang C, Jin G, Jin H, Wang N, Luo Q, Zhang Y, Gao D, Jiang K, Gu D, Shen Q, Huo X, Hu F, Ge T, Zhao F, Chu W, Shu H, Yao M, Cong W*, Qin W* （通讯作者） Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma Oncotarget 2015 6(5):2903(论著，通讯作者，IF=6.359)
Jin H, Zhang Y, You H, Tao X, Wang C, Jin G, Wang N, Ruan H, Gu D, Huo X, Cong W*, Qin W* （通讯作者） Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma. Sci Rep 2015 5:10466(论著，通讯作者，IF=5.578)
Ge T, Shen Q, Wang N, Zhang Y, Ge Z, Chu W, Lv X, Zhao F, Zhao W, Fan J, Qin W* （通讯作者） Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma. Med Oncol 2015 32(3):367(论著，通讯作者，IF=2.634)
Luo Q, Zhang Y, Wang N, Jin G, Jin H, Gu D, Tao X, Huo X, Ge T, Cong W, Wang C*, Qin W* （通讯作者） Leukemia inhibitory factor receptor is a novel immunomarker in distinction of well-differentiated HCC from dysplastic nodules. Oncotarget 2015 6(9):6989(论著，通讯作者，IF=6.359)
Zhang Y, Luo Q, Wang N, Hu F, Jin H, Ge T, Wang C*, Qin W* （通讯作者） LRG1 suppresses the migration and invasion of hepatocellular carcinoma cells Med Oncol 2015 32(5):146(论著，通讯作者，IF=2.634)
Song J, Ge Z, Yang X, Luo Q, Wang C, You H, Ge T, Deng Y, Lin H, Cui Y, Chu W, Yao M, Zhang Z, Gu J, Fan J*, Qin W* （通讯作者） Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin. Cancer Lett 2015 356(2 Pt B):713(论著，通讯作者，IF=5.621)
Huang Y, Yang X, Zhao F, Shen Q, Wang Z, Lv X, Hu B, Yu B, Fan J*, Qin W*. （通讯作者） Overexpression of Dickkopf-1 predicts poor prognosis for patients with hepatocellular carcinoma after orthotopic liver transplantation by promoting cancer metastasis and recurrence. Med Oncol 2014 31(7):966(论著，通讯作者，IF=2.634)
Fan S, Niu Y, Tan N, Wu Z, Wang Y, You H, Ke R, Song J, Shen Q, Wang W, Yao G, Shu H, Lin H, Yao M, Zhang Z, Gu J, Qin W*. （通讯作者） LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. Oncogene 2013 Mar 28;32(13):1682-90(论著，通讯作者，IF=8.559)
Niu Y, Wu Z, Shen Q, Song J, Luo Q, You H, Shi G, Qin W* （通讯作者） Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis Digestive and Liver Disease 2013 Dec;45(12):1041-8(论著，通讯作者，IF=2.889)
Shen Q, Fan J, Yang XR, Tan Y, Zhao W, Xu Y, Wang N, Niu Y, Wu Z, Zhou J, Qiu SJ, Shi YH, Yu B, Tang N, Chu W, Wang M, Wu J, Zhang Z, Yang S, Gu J, Wang H, Qin W* （通讯作者） Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study. The Lancet Oncology 2012 13(8):817-26（论著，通讯作者，IF=25.117）
Shen Q, Wang N, Yang XR, Zhao W, Qin W* （通讯作者） Dickkopf-1 and hepatocellular carcinoma - Authors' reply The Lancet Oncology 2012 13(10):e410-1（通讯，通讯作者，IF=25.117）