导师姓名： 屠红 专业代码： 100214
性别： 女 专业名称： 肿瘤学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市斜土路2200弄25号上海市肿瘤研究所常用邮箱 tuhong@shsci.org
邮编： 200032 邮箱地址： tuhong66@yahoo.com

研究方向 (点击浏览详细信息)
消化系统肿瘤的的分子病因和系统调控

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 良性心理应激通过调控线粒体能量代谢途径抑制肿瘤生长的机制研究 国家自然科学基金（面上项目） 2019-01~2023-12 57万元 课题负责人
2017YFC** 肝癌/肝炎临床和社区人群大型队列研究 国家重点研发计划精准医学研究专项 2017-07~2020-12 1326万元 课题参与人
2017ZX**-008-003 农村乙肝重点人群早期干预方案技术研究与效果评价 “艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项 2017-01~2020-12 265万元 子课题负责人
** 胰腺癌中乙肝病毒整合及整合靶基因MLL4的插入诱变机制研究 国家自然科学基金（面上项目） 2016-01~2019-12 78万元 课题负责人
2012ZX**-002 基于HBV 变异的启东肝癌风险模型的验证及应用 国家科技重大专项 2012-01~2015-12 163万元 子课题负责人
2008ZX10002-015 经肝炎向肝癌发展病程中的流行病学研究 国家科技重大专项 2008-10~2010-12 90万元 子课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang Q, Li M, Gan Y, Jiang S, Qiao J, Zhang W, Fan Y, Shen Y, Song Y, Meng Z, Yao M, Gu J, Zhang Z, Tu H. （通讯作者） Mitochondrial Protein UQCRC1 Is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer Theranostics 2020 10(5):2141-2157
Meng Z, Liu T, Song Y, Wang Q, Xu D, Jiang J, Li M, Qiao J, Lu X, Gu J, Tu H （通讯作者）, Gan Y Exposure to an Enriched Environment Promotes the Terminal Maturation and Proliferation of Natural Killer cells in Mice Brain, Behavior, and Immunity 2019 77:150-160
Jiang J, Fan Y, Zhang W, Shen Y, Liu T, Yao M, Gu J, Tu H （通讯作者）, Gan Y Adiponectin suppresses human pancreatic cancer growth through attenuating the β-catenin signaling pathway Int J Biol Sci 2019 15(2):253-64
Li M, Gan Y, Fan C, Yuan H, Zhang X, Shen Y, Wang Q, Meng Z, Xu D, Tu H （通讯作者） Hepatitis B virus and risk of non-Hodgkin lymphoma: An updated meta-analysis of 58 studies. J Viral Hepat 2018 25(8):894-903
Chunsun Fan, Mengge Li, Yu Gan, Taoyang Chen, Yan Sun, Jianhua Lu, Jinbing Wang, Yan Jin, Jianquan Lu, Gengsun Qian, Jianren Gu, Jianguo Chen, Hong Tu （通讯作者） A simple AGED score for risk classification of primary liver cancer: development and validation with long-term prospective HBsAg-positive cohorts in Qidong, China Gut 2018 gutjnl-2018-316525
Chen T, Qian G, Fan C, Sun Y, Wang J, Lu P, Xue X, Wu Y, Zhang Q, Jin Y, Wu Y, Gan Y, Lu J, Kensler TW, Groopman JD, Tu H. （通讯作者） Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer Hepatoma Res 2018 4. pii: 4
Shen Y, Gan Y, Gao H, Fan Y, Wang Q, Yuan H, Song Y, Wang J, Tu H （通讯作者） TNFSF9 exerts an inhibitory effect on hepatocellular carcinoma J Dig Dis 2017 18(7):395-403
Song Y, Gan Y, Wang Q, Meng Z, Li G, Shen Y, Wu Y, Li P, Yao M, Gu J, Tu H （通讯作者） Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve-Dependent Regulation of NKG2D and CCR5 Cancer Res 2017 77(7):1611-1622
Wu Y, Gan Y, Yuan H, Wang Q, Fan Y, Li G, Zhang J, Yao M, Gu J, Tu H （通讯作者） Enriched environment housing enhances the sensitivity of mouse pancreatic cancer to chemotherapeutic agents. Biochem Biophys Res Commun 2016 473(2) :593-9
Fan Y, Gan Y, Sheng Y, Cai X, Song Y, Zhao F, Yao M, Gu J, Tu H （通讯作者） Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production Oncotarget 2015 6(18):16120-34
Xu J, Xu L, Yang B, Wang L, Lin X, Tu H （通讯作者） Assessing methylation status of PAX1 in cervical scrapings, as a novel diagnostic and predictive biomarker, was closely related to screen cervical cancer. Int J Clin Exp Pathol 2015 8(2):1674-81
Xu J, Xu L, Yang B, Wang L, Lin X, Tu H （通讯作者） ssessing methylation status of PAX1 in cervical scrapings, as a novel diagnostic and predictive biomarker, was closely related to screen cervical cancer. Int J Clin Exp Pathol 2015 8(2):1674-81
Li G, Gan Y, Fan Y, Wu Y, Lin H, Song Y, Cai X, Yu X, Pan W, Yao M, Gu J, Tu H. （通讯作者） Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells. Sci Rep 2015 5: 7856-64
Xu J, Xu L, Yang B, Wang L, Lin X, Tu H （通讯作者） Assessing methylation status of PAX1 in cervical scrapings, as a novel diagnostic and predictive biomarker, was closely related to screen cervical cancer. Int J Clin Exp Pathol 2015 8(2):1674-81
Zhao ZM, Jin Y, Gan Y, Zhu Y, Chen TY, Wang JB, Sun Y, Cao ZG, Qian GS, Tu H （通讯作者） Novel approach to identifying the hepatitis B virus pre-S deletions associated with hepatocellular carcinoma World J Gastroenterol 2014 2014, 20(37): 13573-81
Wu Y, Gan Y, Gao F, Zhao Z, Jin Y, Zhu Y, Sun Z, Wu H, Chen T, Wang J, Sun Y, Fan C, Xiang Y,Qian G, Groopman JD, Gu J, Tu H. （通讯作者） Novel Natural Mutations in the Hepatitis B Virus Reverse Transcriptase Domain Associated with Hepatocellular Carcinoma Plos One 2014 9(5):e94864
Cai X, Gan Y, Fan Y, Hu J, Jin Y, Chen F, Chen T, Sun Y, Wang J, Qin W, Tu H （通讯作者） The adiponectin gene single-nucleotide polymorphism rs** is associated with hepatocellular carcinoma risk Clin Transl Oncol 2014 16(2):166-72
Jin Y, Gao H, Chen H, Wang J, Chen M, Li G, Wang L, Gu J, Tu H （通讯作者） Identification and impact of hepatitis B virus DNA and antigens in pancreatic cancer tissues and adjacent non-cancerous tissues Cancer Lett 2013 335(2):447-54
Chen M, Li G, Yan J, Lu X, Cui J, Ni Z, Cheng W, Qian G, Zhang J, Tu H （通讯作者） Reevaluation of glypican-3 as a serological marker for hepatocellular carcinoma. Clin Chim Acta 2013 423:105-11
Zhu Y, Jin Y, Cai X, Bai X, Chen M, Chen T, Wang J, Qian G, Gu J, Li J, Tu H （通讯作者） Mutation pattern of hepatitis B virus core protein derived from hepatocellular carcinoma Intervirology 2012 55(1):29-35
Bai X, Zhu Y, Jin Y, Guo X, Qian G, Chen T, Zhang J, Wang J, Groopman JD, Gu J, Tu H （通讯作者） Temporal acquisition of sequential mutations in the enhancer II and basal core promoter of HBV in individuals at high-risk for hepatocellular carcinoma Carcinogenesis 2011 32(1):63-8
Zhu Y, Jin Y, Guo X, Bai X, Chen T, Wang J, Qian G, Groopman JD, Gu J, Li J, Tu H （通讯作者） Comparison study of complete sequences of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev 2010 19(10):2623-30
Zhu Y, Jin Y, Guo X, Bai X, Chen T, Wang J, Qian G, Groopman JD, Gu J, Li J, Tu H （通讯作者） Comparison study of complete sequences of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev 2010 19(10):2623-30
Tu H, Hsuchou H, Kastin AJ, Wu X, Pan W Unique leptin trafficking by a tailless receptor FASEB J 2010 24(0):000-published online mar 11
Guo X, Jin Y, Qian G, Tu H （通讯作者） Sequential accumulation of the mutations in core promoter of hepatitis B virus is associated with the development of hepatocellular carcinoma in Qidong, China J Hepatol 2008 49(5):718-25
Cao Z, Bai X, Guo X, Jin Y, Qian G, Tu H （通讯作者） High prevalence of hepatitis B virus pre-S mutation and its association with hepatocellular carcinoma in Qidong, China. Arch virol 2008 153(10):1807-12
Tu H, Pan W, Fencht L, Kastin AJ Convergent trafficking pattern of leptin after endocytosis mediated by ObRa-ObRd J Cell Physiol 2007 212(1):215-222
Tu H, Kastin AJ, and Pan W Corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 are both trafficking and signaling receptors for urocortin Mol Endocrinol 2007 21(3):700-711
Tu H, Kastin AJ, Tao Peng, Bjorbek C, Pan W Urocortin trafficking in cerebral microvessel endothelial cells J Mol Neurosci 2007 31(2):171-182