导师姓名： 金浩杰 专业代码： 100214
性别： 男 专业名称： 肿瘤学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： hjjin1986@shsci.org

研究方向 (点击浏览详细信息)
肿瘤微环境
CRISPR/Cas9功能基因组学与肿瘤靶向治疗

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
19QA** 亚胺甲基转移酶环化脱氨酶在肝癌中的作用及分子机制 上海市青年科技启明星计划 2019-04~2022-03 40万元 课题负责人
2018ZX**-002 乙肝相关肝癌精准诊疗标志物的研发与转化 国家科技重大专项子任务 2018-01~2020-12 35万元 子课题负责人
** 肿瘤酸性微环境调控自噬促进肝癌细胞抗失巢凋亡的分子机制 国家自然科学基金青年项目 2018-01~2020-12 20万元 课题负责人
16ZR** 肝特异性敲除LASS2抑制小鼠肝再生过程的机制研究 上海市自然科学基金 2016-07~2019-06 20万元 课题负责人
YG2015QN34 RCAN1.4调控肿瘤血管生成及肝癌转移的分子机理研究 上海交通大学医工交叉基金 2016-01~2018-12 12万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Cun Wang#, Serena Vegna#, Haojie Jin# （共同第一作者）, Bente Benedict#, Cor Lieftink, Christel Ramirez, Rodrigo Leite de Oliveira, Ben Morris, Jules Gadiot, Wei Wang, Aimée du Chatinier, Liqin Wang, Dongmei Gao, Bastiaan Evers, Guangzhi Jin, Zheng Xue, Arnout Schepers, Fleur Jochems, Antonio Mulero Sanchez, Sara Mainardi, Hein te Riele, Roderick L. Beijersbergen, Wenxin Qin*, Leila Akkari*, René Bernards*. Inducing and exploiting vulnerabilities for the treatment of liver cancer. Nature 2019 574(7777):268-272.
Haiqiu Wu#, Cun Wang#, Jiaxin Sun#, Luyan Sun, Jiaxun Wan, Siying Wang, Dishui Gu, Chengtao Yu, Chen Yang, Jia He, Zihao Zhang, Yuanyuan Lv, Hui Wang, Ming Yao, Wenxin Qin*, Changchun Wang*, Haojie Jin* （通讯作者） Self-Assembled and Self-Monitored Sorafenib/Indocyanine Green Nanodrug with Synergistic Antitumor Activity Mediated by Hyperthermia and Reactive Oxygen Species-Induced Apoptosis. ACS Appl Mater Interfaces. 2019 11(47):43996-44006
Cun Wang#, Haojie Jin# （共同第一作者）, Dongmei Gao#, Cor Lieftink, Bastiaan Evers, Guangzhi Jin, Zheng Xue, Liqin Wang, Roderick L.Beijersbergen, Wenxin Qin*, René Bernards*. Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer. Journal of Hepatology 2018 69(5):1057-1065.
Cun Wang#, Haojie Jin# （共同第一作者）, Dongmei Gao#, Liqin Wang, Bastiaan Evers, Zheng Xue, Guangzhi Jin, Cor Lieftink, Roderick L. Beijersbergen, Wenxin Qin*, René Bernards*. A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma. Cell Research. 2018 28(6):690-692
Jin Haojie#, Wang Cun#, Gu Dishui#, Zhang Yurong, Fan Shaohua, Xing Shunpeng, Wang Hui, Ruan Haoyu, Yang Cheng, Lv Yuanyuan, Feng Hugang, Yao Ming, Qin Wenxin*. Liver-specific deletion of LASS2 delayed regeneration of mouse liver after partial hepatectomy. Biochem Biophys Res Commun. 2017 493(3):1176-1183.
Jin Haojie#, Wang Cun#, Jin Guangzhi#, Ruan Haoyu, Gu Dishui, Wei Lin, Wang Hui, Wang Ning, Arunachalam Einthavy, Zhang Yurong, Deng Xuan, Yang Chen, Xiong Yi, Feng Hugang, Yao Ming, Fang Jingyuan, Gu Jianren, Cong Wenming*, Qin Wenxin*. Regulator of Calcineurin 1 Gene Isoform 4, Downregulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1. Gastroenterology. 2017 153(3):799-811.
Haoyu Ruan#, Chen Yang#, Xuemei Tao, Jia He, Ting Wang, Hui Wang, Cun Wang, Guangzhi Jin, Haojie Jin* （通讯作者）, Wenxin Qin*. Downregulation of ACSM3 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma. American Journal of Cancer Research. 2017 7(3):543-553.
Wu Haiqiu#, Jin Haojie# （共同第一作者）, Wang Cun,Zhang Zihao, Ruan Haoyu, Sun Luyan, Yang Chen, Li Yongjing, Qin Wenxin*, Wang Changchun*. Synergistic Cisplatin/Doxorubicin Combination Chemotherapy for Multidrug-Resistant Cancer via Polymeric Nanogels Targeting Delivery. ACS Appl Mater Interfaces. 2017 9(11):9426-9436.
Haoyu Ruan#, Ting Wang#, Chen Yang, Guangzhi Jin, Dishui Gu, Xuan Deng, Cun Wang, Wenxin Qin*, Haojie Jin*. （通讯作者） Co-expression of LASS2 and TGF-β1 predicts poor prognosis in hepatocellular carcinoma. Scientific Reports. 2016 6:32421.
Dishui Gu#, Haojie Jin# （共同第一作者）, Guangzhi Jin, Cun Wang, Ning Wang, Fangyuan Hua, Qin Luo, Wei Chu, Ming Yao, Wenxin Qin*. Asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity. Cancer Letters. 2016 379(1):107-116.
Jin Haojie#, Zhang Yurong#, You Haiyan#, Tao Xuemei, Wang Cun, Jin Guangzhi, Wang Ning, Ruan Haoyu, Gu Dishui, Huo Xisong, Cong Wenming*, Qin Wenxin*. Prognostic significance of KMO and effects on proliferation, migration and invasion of human hepatocellular carcinoma. Scientific Reports. 2015 5:10466.
Jin HaoJie, Sui Huaxiu, Wang Yinan, Gao Fengguang*. Nicotine up-regulated 4-1BBL expression by activating Mek-PI3K pathway augments the efficacy of bone marrow-derived dendritic cell vaccination. Journal of Clinical Immunology. 2013 33(1): 246-254.
Jin HaoJie, Li Haitao, Sui Huaxiu, Xue Maoqiang, Wang Yinan, Wang Jiaxun, Gao Fengguang*. Nicotine stimulated bone marrow-derived dendritic cells could augment HBV specific CTL priming by activating PI3K-Akt pathway. Immunology Letters. 2012 146(1-2): 40-49.