导师姓名： 王红阳 专业代码： 100214
性别： 女 专业名称： 肿瘤学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： hywangk@vip.sina.com
邮编： 邮箱地址： hywangk@vip.sina.com

研究方向 (点击浏览详细信息)
肿瘤信号转导与网络调控，肿瘤分子机制研究

社会任职
国家自然科学基金委员会医学科学部首届主任(2009-2017)
国家973肿瘤学、蛋白质组学研究等重大基础研究项目专家委员会的成员
中国抗癌协会 副理事长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 肝脏微器官/类器官培养体系的建立、功能调控及其在重大疾病中的应用 国家自然科学基金重点项目 2019-01~2023-12 296万元 课题负责人
** 基于新靶点Gankyrin的个性化药物筛选研究 上海市科委 2015-07~2018-06 50万元 课题负责人
2015ZX09J15107 快速止血药盒的研究开发 国家传染病重大专项重大新药创制 2015-01~2018-12 387.52万元 课题负责人
** 炎症促进细胞癌变的分子调控 NSFC-创新研究群体科学基金 2013-01~2015-12 600万元 课题负责人
2012ZX10002-009 肝炎进展为肝癌的早期诊断标志物筛选验证、分子分型与诊断试剂研发 国家传染病重大专项 2011-10~2015-12 4538.4万元 课题负责人
2008ZX10002-017 肝炎进展为肝癌的早期诊断标志物筛选与诊断试剂研制 国家传染病重大专项 2008-10~2010-12 3464.68万元 主要责任人
07DJ14006 肝癌新型分子标志物筛查鉴定及应用的基础研究 上海市科委 2007-10~2009-08 600万元 课题负责人
信号调节蛋白SIRP在肿瘤天然和获得性免疫中的信号转导机制和应用研究 国家自然科学基金 2007-01~2009-12 80万元 课题负责人
06dj14009 肝癌癌蛋白Gankyrin相关信号通路的系统性研究 上海市科委 2006-12~2009-10 250万元 课题负责人
** 肝癌癌蛋白p28GANK相关的凋亡信号网络调控研究 国家自然科学基金 2006-01~2009-12 150万元 课题负责人
2004CB518703 细胞癌变的跨膜信号转导与分子靶标的研究 国家重点基础研究 2004-09~2009-07 210万元 主要责任人
03DJ14007 肝癌标志分子和药靶筛选及其临床应用研究 上海市科委 2003-08~2006-12 320万元 主要责任人
** 一组肝癌相关基因异常表达、突变及信号转导机制的研究 国家自然科学基金 2002-01~2004-12 80万元 课题负责人
2001AA221021 影响肝癌发生发展的重要功能基因的鉴定和开发利用 国家科技攻关计划 2001-01~2003-12 90万元 主要责任人
** 信号调节蛋白SIRP的三维结构、基因与功能研究 国家自然科学基金 1999-01~2002-12 100万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Liang Li, Jing Tang, Baohua Zhang, Wen Yang, Miyang LiuGao, Ruoyu Wang, Yexiong Tan, Jianling Fan, Yanxin Chang, Jing Fu, Feng Jiang, Caiyang Chen, Yingcheng Yang, Jin Gu, Dingming Wu, Linna Guo, Dan Cao, Hengyu Li, Guangwen Cao, Mengchao Wu, Michael.Q Zhang, Lei Chen and Hongyang Wang. Epigenetic Modification of MiR-429 Promotes Liver Tumor-Initiating Cells Properties by Targeting Rb Binding Protein 4. gut 2015 64(1):156-67.
Su B, Luo T, Zhu J, Fu J, Zhao X, Chen L, Zhang H, Ren Y, Yu L, Yang X, Wu M, Feng G, Li S, Chen Y, Wang H*. （通讯作者） Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis. Hepatology. 2015 61(2):585-97.
Pan YF, Tan YX, Wang M, Zhang J, Zhang B, Yang C, Ding ZW, Dong LW, Wang HY*. （通讯作者） Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression. Hepatology 2013 58(2):680-91.
RuoYu Wang, Lei Chen, HaiYang Chen, Liang Li, HanYong Sun, Feng Jiang, GaoMinyang Liu, Jing Tang, CaiYang Chen, YingCheng Yang, YanXin Chang, Hui Liu, Jin Zhang, Yuan Yang, MengChao Wu, Feng Shen, WeiPing Zhou, and HongYang Wang*. （通讯作者） MUC15 Inhibits Dimerization of EGFR and PI3K–AKT Signaling and Is Associated with Aggressive Hepatocellular Carcinomas in Patients. Gastroenterology 2013 145(6):1436-48.e1-12
Qian YW, Chen Y, Yang W, Fu J, Cao J, Ren YB, Zhu JJ, Su B, Luo T, Zhao XF, Dai RY, Li JJ, Sun W, Wu MC, Feng GS, Wang HY* （通讯作者） p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor-Initiating Cells in Hepatocarcinogenesis. Gastroenterology 2012 142(7):1547-1558
Wen W, Jin Ding, Wen Sun, Jing Fu, Yao Chen, Kun Wu, Beifang Ning, Tao Han, Lei Huang, Cheng Chen, Dong Xie, Zhong Li,Gensheng Feng, Mengchao Wu, Weifen Xie, and Hongyang Wang*. （通讯作者） Cyclin G1-mediated Epithelial-mesenchymal Transition via PI3-K/Akt Signaling Facilitates Liver Cancer Progression. Hepatology 2012 55(6):1787-98
Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY*. Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology 2012 56(6):2255-67
Qiujin Shen*, Jia Fan*, Xin-Rong Yang*, Yexiong Tan*, Weifeng Zhao*, Yang Xu, Ning Wang, Yongdong Niu, Zheng Wu, Jian Zhou, Shuang-Jian Qiu, Ying-Hong Shi, Bin Yu, Ning Tang, Wei Chu, Min Wang, Jinhua Wu, Zhigang Zhang, Shengli Yang, Jianren Gu, Hongyang Wang, Wenxin Qin*. Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study. Lancet Oncol. 2012 13(8):817-26
Chao Wang, Wen Yang, Hexin Yan, Tao Luo, Jian Zhang, Liang Tang,Fuquan Wu,Huilu Zhang, Lexing Yu, Longyi Zheng, Yuqiong Li,Wei Dong, Yaqin He, Qiong Liu,Shanshan Zou, Yan Lin, Liang Hu, Zhong Li , Mengchao Wu and Hongyang Wang *. HBx Induces Tumorigenicity of Hepatic Progenitor Cells in 3,5-diethoxycarbonyl- 1,4-dihydrocollidine (DDC) Treated HBx Transgenic Mice. Hepatology 2012 55(1):108-20
Liang Li, Lei Chen, Liang Hu, Yuan Liu, Hanyong Sun, Jing Tang, Yujie Hou, Yanxin Chang, Qianqian Tu, Gensheng Feng, Feng Shen, Mengchao Wu and Hongyang Wang *. The nuclear factor High-mobility group box1 mediating the activation of TLR4 signaling in hepatocytes in the early stage of NAFLD in mice. Hepatology 2011 54(5):1620-30
Wen Sun, Jin Ding, Kun Wu, Beifang Ning, Wen Wen, Hanyong Sun, Tao Han,Lei Huang, Liwei Dong, Wen Yang, Xing Deng, Zhong Li, Mengchao Wu, Gensheng Feng, Weifen Xie, and Hongyang Wang * （通讯作者） Gankyrin-mediated Dedifferentiation Facilitates the Tumorigenicity of Hepatocytes and Hepatoma cells Hepatology 2011 54(4):1259-72
Hanyong Sun, Lei Chen, Weiping Zhou, Liang Hu, Liang Li, Yanxin Chang, Qianqian Tu, Qu Liu, Xuejun Sun, Mengchao Wu, Hongyang wang* （通讯作者） The Protective Role of Hydrogen-Rich Saline in Experimental Liver Injury in Mice J Hepatol. 2011 54(3):471-80
Liwei Dong, Guangzhen Yang, Yufei Pan, Yao Chen, Yexiong Tan, Rongyang Dai, Yibin Ren, Jing Fu, Hongyang Wang* （通讯作者） The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling Cell Res. 2011 21(8):1248-61
Jing Fu, Yao Chen, Jie Cao, Tao Luo, Youwen Qian, Wen Yang, Yibin Ren, Bo Su, Guangwen Cao, Yuan Yang, Yiqun Yan, Feng Shen, Mengchao Wu, Gensheng Feng and Hongyang Wang* p28GANK Overexpression Accelerates Hepatocelluar Carcinoma Invasiveness and Metastasis via PI3K/AKT/HIF-1α Pathways Hepatology 2011 53(1):181-92
Wen Wen, Jin Ding, Wen Sun, Kun Wu, Beifang Ning, Wenfeng Gong, Guoping He, Shanna Huang, Xinyu Ding, Peipei Yin, Lei Chen, Qiong Liu, Wei-Fen Xie, Hongyang Wang （通讯作者） Suppression of Cyclin D1 by Hypoxia-Inducible Factor-1 via Direct Mechanism Inhibits the Proliferation and 5-Fluorouracil-induced apoptosis of A549 Cells. CANCER RESEARCH 2010 70(5):2010-2019
Lei Chen, Henxin Yan, Wen Yang, Liang Hu, Lexing Yu, Qiong Liu, Liang Li, Dandan Huang, Jin Ding, Feng Shen, Weiping Zhou, Mengchao Wu, Hongyang Wang （通讯作者） The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma Journal of Hepatology 2009 50:358-369
Qiong Liu, Bo Zhai, Wen Yang, Le-Xing Yu, Wei Dong, Ya-Qin He, Lei Chen, Liang Tang, Yan Lin,Dan-Dan Huang, Hong-Ping Wu, Meng-Chao Wu, He-Xin Yan,Hong-Yang Wang （通讯作者） Abrogation of Local Cancer Recurrence after Radiofrequency Ablation by Dendritic Cell-based Hyperthermic Tumor Vaccine. Molecular Therapy 2009
Rong-Yang Dai, Yao Chen, Jing Fu, Li-Wei Dong, Yi-Bin Ren, Guang-Zhen Yang, You-Wen Qian, Jie Cao, Shan-Hua Tang, Sheng-Li Yang, Hongyang Wang （通讯作者） p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity Cell Research 2009 1243-1257
Jin Ding, Guoping He, Wenfeng Gong, Wen Wen, Wen Sun,Beifang Ning,Shanna Huang,Kun Wu, Chuanshu Huang, Mengchao Wu, Weifen Xie,Hongyang Wang （通讯作者） Effects of Nickel on Cyclin Expression, Cell Cycle Progression and Cell Proliferation in Human Pulmonary Cells Cancer Epidemiology, Biomarkers & Prevention 2009 18(6):1720-1729
Jin Ding, Beifang Ning, Wenfeng Gong, Wen Wen, Kun Wu, Junqing Liang, Guoping He, Shanna Huang,Wen Sun, Tao Han, Lei Huang, Guangwen Cao, Mengchao Wu, Weifen Xie,Hongyang Wang （通讯作者） Cyclin D1 Induction by Benzo[a]pyrene-7,8-diol-9,10-epoxide, via PI-3K/Akt/MAPKs and p70s6k-dependent Pathway, Promotes Cell Transformation and Tumorigenesis Journal Biological Chemistry 2009 Accepted
Wen Yang, He-Xin Yan, Lei Chen, Qiong Liu, Ya-Qin He, Le-Xing Yu, Shu-Hui Zhang, Dan-Dan Huang, Liang Tang, Xiao-Ni Kong, Chao Chen, Shu-Qin Liu, Meng-Chao Wu,Hong-Yang Wang （通讯作者） Wnt/β-Catenin Signaling Contributes to Activation of Normal and Tumorigenic Liver Progenitor Cells Cancer Research 2008 68 (11):4287-4295
Li-Wei Dong, Xiao-Ni Kong, He-Xin Yan, Le-Xing Yu, Lei Chen,Wen Yang, Qiong Liu, Dan-Dan Huang, Meng-Chao Wu, Hong-Yang Wang （通讯作者） Signal regulatory protein _ negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction Molecular Immunology 2008 45:3025-3035
Xuefeng Wang, Honghai Li, Yao Chen, Jing Fu, Yibin Ren, Liwei Dong, Shanhua Tang, Shuqin Liu, Mengchao Wu,Hongyang Wang （通讯作者） p28GANK knockdown-derived reactive oxygen species induces apoptosis through mitochondrial dysfunction mediated by p38 in HepG2 cells International Journal of Oncology 2008 33: 743-750
Lei Chen, He-Xin Yan, Jing Chen, Wen Yang, Qiong Liu, Bo Zhai, Hui-Fang Cao, Shu-Qin Liu, Meng-Chao Wu,Hong-Yang Wang （通讯作者） Negative Regulation of c-Myc Transcription by Pancreas Duodenum Homeobox-1 Endocrinology 2007 148(5):2168–2180
Xiao-Ni Kong, He-Xin Yan, Lei Chen, Li-Wei Dong, Wen Yang, Qiong Liu, Le-Xing Yu, Dan-Dan Huang, Shu-Qin Liu, Hui Liu, Meng-Chao Wu,Hong-Yang Wang （通讯作者） LPS-induced down-regulation of signal regulatory proteinαcontributes to innate immune activation in macrophages The Journal of Experimental Medicine 2007 24(11):2719-2731
Yao Chen, Hong-Hai Li, Jing Fu, Xue-Feng Wang, Yi-Bin Ren, Li-Wei Dong, Shan-Hua Tang, Shu-Qing Liu, Meng-Chao Wu,Hong-Yang Wang （通讯作者） Oncoprotein p28GANK binds to RelA and retains NF-κB in the cytoplasm through nuclear export Cell Research 2007 17(12):1020-1029
He-Xin Yan, Wen Yang, Rui Zhang, Lei Chen, Liang Tang, Bo Zhai, Shu-Qin Liu, Hui-Fang Cao, Xiao-Bo Man, Hong-Ping Wu, Meng-Chao Wu,Hong-Yang Wang （通讯作者） Protein Tyrosine Phosphatase PCP-2 Inhibits β--Catenin Signaling and Increases E-cadherin-dependent Cell Adhesion J. Biological Chemistry 2006 281(22): 15423-15433
Jianhua Ai, Yexiong Tan, Wantao Ying, Yi Hong, Shuqing Liu, MengchaoWu,Xiaohong Qian,HongyangWang （通讯作者） Proteome analysis of hepatocellular carcinoma by laser capture microdissection Proteomics 2005 6(2):538-546
Tan L, Fu X-Y, Liu S-Q, Li H-H, Hong Y, Wu M-C, Wang H-Y （通讯作者） Expression of p28GANK and its correlation with RB in hunman hepatocellular carcinoma liver 2005 25:1-9
Li HH, Fu XY, Chen Y, Hong Y, Tan YX, Cao HF, Wu MC,Wang HY （通讯作者） Use of Adenovirus-delivered SiRNA to Target Oncoprotein p28GANK in Hepatocellular Carcinoma Gastroenterology 2005 128(7):2029-41
Man XB, Tang L, Zhang BH, Li SJ, Qiu XH, Wu MC,Wang HY （通讯作者） Upregulation of GPC3 Expression in Hepatocellular Carcinoma but Downregulation in Cholangiocarcinoma Indicates its Differential Diagnosis Value in Primary Liver Cancers liver 2005 25(5):962-966
Li C,Tan YX, Zhou H, Ding SJ, Li SJ, Ma DJ, Man XB, Hong Y, Zhang L, Li L,Xia QC, Wu JR, Wang HY （通讯作者）,Zeng R Proteomic analysis of hepatitis B virus-associated hepatocellular carcinoma: Identification of potential tumor markers. Proteomics 2005 5:1125-1139.
He-Xin Yan, Yi Zhang,Hong-Yang Wang. （通讯作者） Negative Regulation of Hepatocellular Carcinoma Cell Growth by Signal Regulatory Protein α1 Hepatology 2004 40(3):618-628
He-Xin Yan, Ya-Qin He, Hui Dong, Peng Zhang, Jin-Zhang Zeng, Hui-Fang Cao, Meng-Chao Wu,Hong-Yang Wang （通讯作者） Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin. Biochemistry 2002 41:15854-15860