导师姓名： 冯海忠 专业代码： 100214
性别： 男 专业名称： 肿瘤学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市浦东新区浦建路160号17号楼1517室
邮编： 200127 邮箱地址： fenghaizhong@mail.sjtu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤干细胞和靶向治疗
肿瘤微环境

社会任职
2014-Review Editor of Cancer Letters
2017-以色列国家自然科学基金评审人
2011-国际神经肿瘤学会正式会员-Society for Neuro-Oncology (SNO)
2020-中国神经学会神经肿瘤分会委员会常务委员
2011-Review Editor of Journal of Chinese Cancer
2019-Review Editor of Advanced Science
2011-Review Editor of Journal of Neuro-Oncology
2017-Review editor of Oncogene
2018-中国生理学会基质生物学专业委员会委员
2019-Review Editor of Advanced Science
2010-美国癌症学会会员-America Association for Cancer Research (AACR)

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** KAT6A依赖的乙酰化SMAD3调控乳腺癌转移的分子机制 国家自然科学基金 2021-01~2024-12 55万元 课题负责人
19JC** GNAO1点突变诱导ETV6-RUNX1阳性白血病转化的分子机制 上海市科学技术委员会基础研究项目 2019-11~2022-10 100万元 课题负责人
** 组蛋白乙酰转移酶KAT6A调控乳腺癌转移的分子机制 上海市教委高峰高原学科建设-上海交通大学医学院“双百人” 2019-07~2022-06 100万元 课题负责人
** TRIM24/STAT3调控胶质瘤干细胞干性的分子机制 国家自然科学基金 2019-01~2022-12 63万元 课题负责人
2017BR021 组蛋白乙酰化调控胶质瘤发展的分子机制 上海市卫生计生系统优秀学科带头人“新百人” 2017-07~2020-06 45万元 课题负责人
** LncRNA-UTB调控TGF-beta介导的胶质瘤干细胞干性维持的分子机制 上海市教委高峰高原学科建设-上海交通大学医学院“双百人” 2016-07~2019-06 100万元 课题负责人
** ZEB1调节神经胶质瘤上皮-间质转化及肿瘤干细胞干性维持的分子机制 国家自然科学基金 2016-01~2019-12 68.4万元 课题负责人
** 上海高校****（****） 上海市教育委员会 2015-01~2017-12 100万元 课题负责人
14ZZ111 泛素化E3连接酶TRAF6调节神经胶质瘤生长与侵袭的分子机制 上海市教育委员会科研创新重点项目 2014-01~2016-12 16万元 课题负责人
** Dock180结合蛋白TRAF6调节神经胶质瘤生长与侵袭的分子机制 国家自然基金 2014-01~2017-12 80万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Lili Song#, Bo Yu#, Yi Yang, Jianwei Liang, Yingwen Zhang, Lixia Ding, Tianyi Wang, Xinyu Wan, Xiaomin Yang, Jingyan Tang, Shengyue Wang*, Benshang Li*, Yanxin Li*, and Haizhong Feng* （通讯作者） Identification of functional cooperative mutations of GNAO1 in human acute lymphoblastic leukemia Blood 2020 00-00
Yanli Hou#, Bowen Sun#, Wenxue Liu, Bo Yu, Qiqi Shi, Fei Luo, Yongrui Bai*, and Haizhong Feng* （通讯作者） Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling Theranostics 2020 00-00
Yinfang Wang, Yanli Hou, Weiwei Zhang, Angel A. Alvarez, Yongrui Bai, Bo Hu, Shi-Yuan Cheng, Kun Yang*, Yanxin Li*, and Haizhong Feng*. （通讯作者） Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response. Journal of Experimental & Clinical Cancer Research 2019 38(1):147
Jianming Tang#, Bo Yu#, Yanxin Li#, Weiwei Zhang, Angel A. Alvarez, Bo Hu, Shi-Yuan Cheng, and Haizhong Feng*. （通讯作者） TGF-beta-activated lncRNA LINC00115 is a critical regulator for glioma stem-like cell tumorigenicity. EMBO Reports 2019 20(12):e48170
Youzhou Sang#, Yanxin Li#, Angel A. Alvarez, Yingwen Zhang, Bo Yu, Weiwei Zhang, Bo Hu, Shi-Yuan Cheng, and Haizhong Feng*. （通讯作者） CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity. Nature Communications 2019 10(1):4013
Youzhou Sang#, Yanli Hou#, Rongrong Cheng, Liang Zheng, Angel A. Alvarez, Bo Hu, Shi-Yuan Cheng, Weiwei Zhang*, Yanxin Li*, and Haizhong Feng*. （通讯作者） Targeting PDGFRa-activated Glioblastoma through Specific Inhibition of SHP-2-mediated Signaling. Neuro-Oncology 2019 21(11):1423-1435
Zhiyan Zhan#, Lili Song#, Weiwei Zhang#, Haihui Gu, Haizi Cheng, Yingwen Zhang, Yi Yang, Guangzhen Ji, Haizhong Feng* （通讯作者）, Tao Cheng *, and Yanxin Li*. Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability. Cell Death & Disease 2019 10(4):271
Jianming Tang, Yanxin Li*, Youzhou Sang, Bo Yu, Deguan Lv, Weiwei Zhang, and Haizhong Feng* （通讯作者） LncRNA PVT1 regulates triple-negative breast cancer through KLF5/beta-catenin signaling Oncogene 2018 37: 4723-4734
Youzhou Sang#, Yanxin Li#,*, Lina Song#, Angel A. Alvarez#, Weiwei Zhang, Deguan Lv, Jianming Tang, Feng Liu, Zhijie Chang, Shigetsugu Hatakeyama, Bo Hu, Shi-Yuan Cheng, and Haizhong Feng* （通讯作者） TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3. Cancer Research 2018 78(7)1792-1804
Deguan Lv#, Yanxin Li#, Weiwei Zhang, Angel A. Alvarez, Lina Song, Jianming Tang, Wei-Qiang Gao, Bo Hu, Shi-Yuan Cheng, and Haizhong Feng* （通讯作者） TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma Nature Communications 2017 8(1):1454:1-13
Deguan Lv#, Feng Jia#, Yanli Hou#, Youzhou Sang, Angel A. Alvarez, Weiwei Zhang,Wei-Qiang Gao, Bo Hu, Shi-Yuan Cheng, Jianwei Ge*, Yanxin Li*, and Haizhong Feng* （通讯作者） Histone acetyltransferase KAT6A upregulates PI3K/AKT signaling through TRIM24 Cancer Research 2017 77(22): 6190-6201
Lei Zhang#, Weiwei Zhang#, Yanxin Li#, Angel Alvarez, Zuoqing Li, Yinfang Wang, Lina Song, Deguan Lv, Ichiro Nakano, Bo Hu, Shi-Yuan Cheng, and Haizhong Feng*. （通讯作者） SHP-2-upregulated ZEB1 is important for PDGFRalpha-driven glioma epithelial-mesenchymal transition and invasion in mice and humans. Oncogene 2016 35(43):5641-5652
Haizhong Feng# （通讯作者）,*, Yanxin Li#, Yuhua Yin#, Weiwei Zhang, Yanli Hou, Lei Zhang, Zuoqing Li, Baoshu Xie, Wei-Qiang Gao, Jann N. Sarkaria, Jeffery J. Raizer, C. David James, Andrew T. Parsa, Bo Hu*, and Shi-Yuan Cheng*. PKA-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by PDGFR ?. Neuro-Oncology 2015 17(6):832-842
Haizhong Feng, Bo Hu, Kristiina Vuori, Jann N. Sarkaria, Frank B. Furnari, Webster K. Cavenee and Shi-Yuan Cheng. EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180. Oncogene 2014 33(19):2504-12.
Haizhong Feng*, Giselle Lopez*, Chunhui Dai, Chungkwon Kim, Ryo Nishikawa, Phillip E. Auron, Jennifer R. Grandis, Hui-Kuan Lin, Frank B. Furnari, Webster K. Cavenee, Bo Hu, Hai Yan and Shi-Yuan Cheng. EGFR-phosphorylation of DCBLD2 Recruits TRAF6 and stimulates Akt-promoted Tumorigenesis. The Journal of Clinical Investigation 2014 124(9):3741-3756.
Yanxin Li#, Haizhong Feng# （共同第一作者）, Youzhong Yuan, Peng Zhang, Haizi Cheng, Hui Yu, Xiaochun Ping, Shi-Yuan Cheng, Dale W. Lewis, Susanne M. Gollin, and Tao Cheng. The p53-PUMA axis suppresses iPSC generation. Nature Communications 2013 4:2174. doi: 10.1038/ncomms3174
Haizhong Feng, Bo Hu, Michael J. Jarzynka, Yanxin Li, Keezer, Susan, Ronald L. Hamilton, Kristiina Vuori, Ryo Nishikawa, Tao Cheng, Frank B Furnari, Webster K Cavenee and Shi-Yuan Cheng. Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis. Proc. Natl Acad. Sci. USA. 2012 109 (8):3018-3023.
H Feng, KW Liu, P Guo, P Zhang, T Cheng, MA McNiven, GR Johnson, B Hu, and SY Cheng. Dynamin 2 Mediates PDGFRα-SHP-2-Promoted Glioblastoma Growth and Invasion. Oncogene 2012 31(21):2691-2702.
Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, Cheng SY. SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans. The Journal of Clinical Investigation 2011 121(3):905-917.
Haizhong Feng, Bo Hu, Kun-Wei Liu, Yanxin Li, Xinghua Lu, Tao Cheng, Jia-Jean Yiin, Songjian Lu, Susan Keezer, Tim Fenton, Frank B. Furnari, Ronald L. Hamilton, Kristiina Vuori, Jann N. Sarkaria, Motoo Nagane, Ryo Nishikawa, Webster K. Cavenee and Shi-Yu Activation of Rac1 by Src-dependent Phosphorylation of Dock180Y1811 mediates PDGFR?-stimulated glioma tumorigenesis in mice and humans. The Journal of Clinical Investigation 2011 121(12):4670-4684.