导师姓名： 姚明 专业代码： 100214
性别： 男 专业名称： 肿瘤学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 地址：上海市斜土路2200弄25号； 电话：；
邮编： 200032 邮箱地址： myao@shsci.org

研究方向 (点击浏览详细信息)
肺癌转移模型及转移分子机制的研究

社会任职
上海市实验动物学会副理事长
《实验动物与比较医学》杂志副主编，《肿瘤》杂志编委
上海医学会肿瘤靶分子专业委员会 委员
上海市实验动物管理委员会专家组成员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 假基因LncRNASUZ12p促进非小细胞肺癌转移的分子机制研究 国家自然科学基金面上项目 2018-01~2021-12 55万元 课题负责人
** USP25基因在非小细胞肺癌转移中的作用及其分子机制研究 国家自然科学基金面上项目 2015-01~2018-12 72万元 课题负责人
2015CB553905 癌前病变发生发展过程中上皮细胞与微环境的交互作用 国家重点基础研究发展计划（973计划） 2015-01~2017-12 202万元 课题参与人
** 建立大肠癌高转移动物模型及评价体系的研究 上海市科委创新行动计划 2013-10~2015-09 45万元 子课题负责人
2013ZX** 解决肝癌耐药的新策略研究 国家科技重大专项课题 2013-01~2015-12 550万元 课题参与人
小动物影像学应用技术平台和数据库的初步建立 上海市科委 2011-12~2014-06 35万元 课题负责人
系列肿瘤转移动物模型的生物学特性研究 上海市科委 2010-05~2012-03 35万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jing Li,Tao Yu,Mingxia Yan, Xiao Zhang, Li Liao, Miaoxin Zhu, Hechun Lin,Hongyu Pan,Ming Yao （通讯作者） DCUN1D1 facilitates tumor metastasis by activating FAK signaling and upregulates PD-L1 in non-small-cell lung cancer Experimental Cell Research 2019 374(2):304-314
Jing Li, Dongdong Cheng, Miaoxin Zhu, Huajian Yu, Zhen Pan, Lei Liu, Qin Geng, Hongyu Pan,Mingxia Yan, Ming Yao （通讯作者） OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer Theranostics 2019 9(1):179-195
Lin HC, Zhang X, Liao L, Yu T, Li J, Pan HY, Liu L, Kong HW, Sun L, Yan MX, Yao M （通讯作者） CPNE3 promotes migration and invasion in non-small cell lung cancer by interacting with RACK1 via FAK signaling activation Journal of Cancer 2018 9(22): 4215-4222
Tao Yu,Yingjun Zhao,Zhixiang Hu,Jing Li,Dandan Chu,Jiwei Zhang,Zhe Li,Bing Chen,Xiao Zhang,Hongyu Pan,Shengli Li,Hechun Lin,Lei Liu,Mingxia Yan,Xianghuo He,Ming Yao （通讯作者） MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway Cancer Research 2017 77(21):5782-5794
YING LIU,LEI LIU,TAO YU,HE?CHUN LIN,DANDAN CHU,WEI DENG,MING?XIA YAN,JING LI,MING YAO （通讯作者） Systematic analysis of mRNA expression profiles in NSCLC cell lines to screen metastasis-related genes Mol Med Rep 2016 14:5093-5103
Aiqin Gu,Jianhong Lu,Weimin Wang,Chunlei Shi,Baohui Han,Ming Yao （通讯作者） Role of miR-497 in VEGF-A-mediated cancer cell growth and invasion in non-small cell lung cancer The International Journal of Biochemistry & Cell 2016 70（2016）:118-125
Wei Deng,Mingxia Yan,Tao Yu,Haiyan Ge,Hechun Lin,Jing Li,Ying Liu,Qin Geng,Miaoxin Zhu,Lei Liu,Xianghuo He,Ming Yao （通讯作者） Quantitative Proteomic Analysis of the Metastasis-Inhibitory Mechanism of miR-193a-3p in Non-Small Cell Lung Cancer Cellular Physiology and Biochemistry 2015 35:1677-1688
Yong-Qi Cui, Qin Geng, Tao Yu, Fang-Lin Zhang, He-Chun Lin, Jing Li, Miao-Xin Zhu, Lei Liu, Ming Yao* （通讯作者）, Ming-Xia Yan* Establishment of a highly metastatic model with a newly isolated lung adenocarcinoma cell line. International journal of oncology 2015 47: 927-940
Tao Yu,Lei Liu,Jing Li,Mingxia Yan,Hechun Lin,Ying Liu,Dandan Chu,Hong Tu,Aiqin Gu,Ming Yao* （通讯作者） miRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN oncotarget 2015 6（30）：30239-30250
T Yu, J Li, M Yan, L Liu, H Lin, F Zhao, L Sun, Y Zhang, Y Cui, F Zhang, J Li, X,M Yao* （通讯作者） MicroRNA-193a-3p and -5p suppress the metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway Oncogene 2015 34:413-423
Jing Li,Tao Yu,Jun Cao,Lei Liu,Ying Liu,Han-Wei Kong,Miao-Xin Zhu,He-Chun Lin,Dan-dan Chu,Ming Yao （通讯作者）,Ming-Xia Yan MicroRNA-148a Suppresses Invasion and Metastasis of Human Non-Small-Cell Lung Cellular Physiology and Biochemistry 2015 37:1847-1856
Li J, Xu Y, Long XD, Wang W, Jiao HK, Mei Z, Yin QQ, Ma LN, Zhou AW, Wang LS, Yao M, Xia Q, Chen GQ Cbx4 Governs HIF-1α to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity? Cancer Cell 2014 5(1):118-131
Fanglin Zhang,Hechun Lin,Aiqin Gu,Jing Li,Lei Liu,Tao Yu,Yongqi Cui,Wei Deng,Mingxia Yan, Jinjun Li, Ming Yao （通讯作者） SWATHTM- and iTRAQ-based quantitative proteomic analyses reveal an overexpression and biological relevance of CD109 in advanced NSCLC Journal of Proteomics 2014 102(3):125-136
Jing Li, Qiang Tan, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Guoliang Bao, Hanwei Kong,Chao Ge, Fanglin Zhang, Tao Yu, Jinjun Li, Xianghuo He, Ming Yao* （通讯作者） miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25 Molecular Cancer 2014 13(166):1-14
He-chun Lin,Fang-lin Zhang,Qin Geng,Tao Yu,Yong-qi Cui, Xiao-hui Liu,Jing Li,Ming-xia Yan,Lei Liu,Xiang-huo He, Jin-jun Li,Ming Yao* （通讯作者） Quantitative Proteomic Analysis Identifies CPNE3 as a Novel Metastasis-promoting Gene in NSCLC Journal of Proteome Research 2013 2(7):3423-3433
Lei Liu, Mingxia Yan, Fangyu Zhao, Jing Li, Chao Ge, Qin Geng, Miaoxin Zhu, Lei Sun,Xianghuo He, Jinjun Li,Ming Yao* （通讯作者） CD26/dipeptidyl peptidase IV contributes to tumor metastasis in human lung adenocarcinoma Bangladesh Journal of Pharmacology 2013 8(2):198-206
Xiao-Min Wang,Jing Li,Ming-Xia Yan,Lei Liu,De-Shui Jia, Qin Geng,He-Chun Lin,Xiang-Huo He, Jin-Jun Li,Ming Yao* （通讯作者） Integrative Analyses Identify Osteopontin, LAMB3 and ITGB1 as Critical Pro-Metastatic Genes for Lung Cancer PLos One 2013 8(2):1-11
Deshui Jia, Mingxia Yan1, Xiaomin Wang, Xiangfang Hao, Linhui Liang, Lei Liu, Hanwei Kong, Xianghuo He, Jinjun Li, Ming Yao （通讯作者） Development of a highly metastatic model that reveals a crucial role of fibronectin in lung cancer cell migration and invasion BMC Cancer 2010 10:364-376.
Jie Ding?, Shenglin Huang?, Yingjun Zhao, Linhui Liang, Mingxia Yan, Chao Ge, Jian Yao, Taoyang Chen, Dafang Wan, Jianren Gu, Ming Yao, Jinjun Li, Hong Tu, Xianghuo He Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA Nature Cell Biology 2010 12(4):390-399