导师姓名： 蔡志伟 专业代码： 100214
性别： 男 专业名称： 肿瘤学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市浦东新区浦建路160号17号楼15楼1515室
邮编： 200127 邮箱地址： cheewaichua@yahoo.com

研究方向 (点击浏览详细信息)
雄激素受体非依赖型前列腺上皮干细胞的鉴定
肿瘤模式创建

社会任职
eLife Community Ambassador

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** Runx2在前列腺癌骨转移发生的机制研究 上海市科委/“一带一路”国际合作-青年科学家交流项目 2019-11~2021-10 30万元 课题负责人
N/A 上海高层次人才项目/学科建设与人才培养 上海交通大学医学院附属仁济医院 2019-07~2025-06 600万元 课题负责人
** 雄激素受体非依赖的管腔祖细胞在神经内分泌型前列腺癌发生的作用及机制研究 国家自然科学基金委 2019-01~2022-12 57万元 课题负责人
90-17-01 癌基因及其他基因国家重点实验室开放课题 国家重点实验室 2018-12~2019-12 15万元 课题负责人
** 上海交通大学医学院“临床专职科研队伍”项目/双**** 上海交通大学医学院 2018-01~2020-12 100万元 课题负责人
TP** 上海市****“****” 上海市教委 2017-01~2019-12 100万元 课题负责人
** 雄激素受体非依赖的上皮祖细胞在前列腺肿瘤发生及去势抵抗进程中的作用机制研究 国家自然科学基金委 2017-01~2020-12 77万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Hanoun M, Arnal-Estapé A, Maryanovich M, Zahalka AH, Bergren SK, Chua CW, Leftin A, Brodin PN, Shen MM, Guha C, Frenette PS. Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate. Stem Cell Reports 2019 12(6):1201-11
Shu Y, Chua CW*. （通讯作者） An organoid assay for long-term maintenance of prostate luminal progenitors and cancers. Methods in Molecular Biology 2019 1940:231-54
Lee SH, Hu W, Matulay JT, Silva MV, Owczarek TB, Kim K, Chua CW, Barlow LJ, Kandoth C, Williams AB, Bergren SK, Pietzak EJ, Anderson CB, Benson MC, Coleman JA, Taylor BS, Abate-Shen C, McKiernan JM, Al-Ahmadie H, Solit DB, Shen MM. Tumor evolution and drug response in patient-derived organoid models of bladder cancer. Cell 2018 173(2):515-528.e17.
Chua CW, Epsi NJ, Leung EY, Xuan S, Lei M, Li BI, Bergren SK, Hibshoosh H, Mitrofanova A, Shen MM. Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation. Elife 2018 pii: e28768
Zhang H, Zheng T, Chua CW, Shen MM, Gelmann EP. Nkx3.1 controls the DNA repair response in the mouse prostate Prostate 2016 76(4):402-8
Chua CW* （共同第一作者）, Shibata M*, Lei M*, Toivanen R, Barlow LJ, Bergren SK, Badani KK, McKiernan JM, Benson MC, Hibshoosh H, Shen MM. Single luminal epithelial progenitors can generate prostate organoids in culture Nature Cell Biology 2014 16(10):951-61.
Hu H, Zhang XP, Wang YL, Chua CW, Luk SU, Wong YC, Ling MT, Wang XF, Xu KX. Identification of a novel function of Id-1 in mediating the anticancer responses of SAMC, a water-soluble garlic derivative, in human bladder cancer cells. Molecular Medicine Reports 2011 4(1):9-16
Chua CW, Chiu YT, Yuen HF, Chan KW, Wang X, Ling MT, Wong YC. Differential expression of Msx2 in nodular hyperplasia, high-grade PIN and prostate adenocarcinoma. APMIS 2010 118(12):918-26
Yuen HF, Chiu YT, Chan KK, Chan YP, Chua CW, McCrudden CM, Tang KH, El-Tanani M, Wong YC, Wang X, Chan KW. Prostate cancer cells modulate osteoblast mineralisation and osteoclast differentiation through Id-1. British Journal of Cancer 2010 102(2):332-41
Chua CW, Chiu YT, Yuen HF, Chan KW, Man K, Wang X, Ling MT, Wong YC. Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform. Clinical Cancer Research 2009 15(13):4322-35
Hu H, Han HY, Wang YL, Zhang XP, Chua CW, Wong YC, Wang XF, Ling MT, Xu KX. The role of Id-1 in chemosensitivity and epirubicin-induced apoptosis in bladder cancer cells. Oncology Reports 2009 21(4):1053-9
Chiu YT, Han HY, Leung SC, Yuen HF, Chua CW, Guo Z, Qiu Y, Chan KW, Wang X, Wong YC, Ling MT. CDC25A functions as a novel Ar corepressor in prostate cancer cells. Journal of Molecular Biology 2009 385(2):446-56
Howard EW, Leung SC, Yuen HF, Chua CW, Lee DT, Chan KW, Wang X, Wong YC. Decreased adhesiveness, resistance to anoikis and suppression of GRP94 are integral to the survival of circulating tumor cells in prostate cancer. Clinical & Experimental Metastasis 2008 25(5):497-508
Howard EW, Lee DT, Chiu YT, Chua CW, Wang X, Wong YC. Evidence of a novel docetaxel sensitizer, garlic-derived S-allylmercaptocysteine, as a treatment option for hormone refractory prostate cancer. International Journal of Cancer 2008 122(9):1941-8
Yuen HF, Kwok WK, Chan KK, Chua CW, Chan YP, Chu YY, Wong YC, Wang X, Chan KW. TWIST modulates prostate cancer cell-mediated bone cell activity and is upregulated by osteogenic induction. Carcinogenesis 2008 29(8):1509-18
Yuen HF, Chua CW, Chan YP, Wong YC, Wang X, Chan KW. Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer. Histopathology 2007 50(5):648-58
Zhang Z, Xie D, Li X, Wong YC, Xin D, Guan XY, Chua CW, Leung SC, Na Y, Wang X. Significance of TWIST expression and its association with E-cadherin in bladder cancer. Human Pathology 2007 38(4):598-606
Li X, Zhang Z, Xin D, Chua CW, Wong YC, Leung SC, Na Y, Wang X. Prognostic significance of Id-1 and its association with EGFR in renal cell cancer. Histopathology 2007 50(4):484-90
Howard EW, Ling MT, Chua CW, Cheung HW, Wang X, Wong YC. Garlic-derived S-allylmercaptocysteine is a novel in vivo antimetastatic agent for androgen-independent prostate cancer. Clinical Cancer Research 2007 13(6):1847-56
Yuen HF, Chua CW, Chan YP, Wong YC, Wang X, Chan KW. Id proteins expression in prostate cancer: high-level expression of Id-4 in primary prostate cancer is associated with development of metastases. Modern Pathology 2006 19(7):931-41
Ding Y, Wang G, Ling MT, Wong YC, Li X, Na Y, Zhang X, Chua CW, Wang X, Xin D. Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion. International Journal of Cancer 2006 28(4):847-54
Kwok WK, Ling MT, Lee TW, Lau TC, Zhou C, Zhang X, Chua CW, Chan KW, Chan FL, Glackin C, Wong YC, Wang X. Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Research 2005 65(12):5153-62
Chua CW, Lee DT, Ling MT, Zhou C, Man K, Ho J, Chan FL, Wang X, Wong YC. FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer. International Journal of Cancer 2005 117(6):1039-48
Ling MT, Lau TC, Zhou C, Chua CW, Kwok WK, Wang Q, Wang X, Wong YC Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF). Carcinogenesis 2005 26(10):1668-76
Norazlina M, Chua CW, Ima-Nirwana S. Vitamin E deficiency reduced lumbar bone calcium content in female rats. Medical Journal of Malaysia 2004 59(5):623-30