导师姓名： 蒋华 专业代码： 100214
性别： 女 专业名称： 肿瘤学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市徐汇区斜土路2200弄25号
邮编： 200032 邮箱地址： jianghuapy@163.com

研究方向 (点击浏览详细信息)
肿瘤抗体药物研发及靶向治疗

社会任职
细胞工程与转基因生物分会委员
上海市免疫学会肿瘤免疫专业委员会委员
上海市免疫学会第十二届理事会理事

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 孤核受体NR2F6对靶向磷脂酰肌醇蛋白聚糖-3的CAR-T细胞 国家自然基金，面上项目 2019-01~2021-12 57万元 课题负责人
** 高度肿瘤特异性的抗EGFR/EGFRvIII双靶向CAR-T细胞的临床前研究 上海市科学技术委员会创新支撑项目 2018-04~2021-06 70万元 课题负责人
敲除孤核受体NR2F6对嵌合抗原受体修饰的T细胞抗实体瘤疗效的影响及机制 上海市卫计委面上项目 2018-01~2020-12 10万元 课题负责人
** 抗表皮生长因子受体突变体III的单克隆抗体CH12对肿瘤细胞自噬作用及机制研究 国家自然基金，面上项目 2014-01~2017-12 75万元 课题负责人
13QA** 靶向EGFR隐蔽表位的嵌合抗原受体基因修饰的T细胞对脑胶质瘤的治疗研究 上海市科技人才计划项目启明星计划（A类） 2013-07~2015-06 20万元 课题负责人
12JC** 抗表皮生长因子受体抗体CH12 用于喉癌的药效学及其个体化用药标志物的研究 上海市科委基础研究重点项目 2013-01~2015-12 40万元 课题负责人
2012ZX**-007 抗表皮生长因子受体新型单抗的临床前药效学研究 国家“十二五”科技重大专项 2012-01~2015-12 123.1万元 课题负责人
** 表皮生长因子受体突变体III(EGFRvIII)对肝癌的5-氟尿嘧啶抗性的作用机制及对策 国家自然基金，青年科学基金项目 2010-01~2012-12 21万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Hua Jiang#, Zhimin Shi#, Peng Wang, Cong Wang, Linlin Yang, Guoxiu Du, Honghong Zhang, Bizhi Shi, Jie Jia, Qixiang Li, Huamao Wang, Zonghai Li* Claudin18.2-specific chimeric antigen receptor engineered T cells for the treatment of gastric cancer J Natl Cancer Inst 2019 111(4):409-418
Dong Q, Shi B, Zhou M, Gao H, Luo X, Li Z, Jiang H* （通讯作者） Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12 Front Med 2019 13(1):83-93
Xiuqi Wu, Hong Luo, Bizhi Shi, Shengmeng Di, Ruixin Sun, Jingwen Su, Ying Liu, Hua Li, Hua Jiang* （通讯作者）, Zonghai Li* Combined Antitumor Effects of Sorafenib and GPC3-CAR T Cells in Mouse Models of Hepatocellular Carcinoma Mol Ther 2019 27(8):1483-1494
Chen M, Sun R, Shi B, Wang Y, Di S, Luo H, Sun Y, Li Z, Zhou M, Jiang H* （通讯作者） Antitumor efficacy of chimeric antigen receptor T cells against EGFRvIII expressing glioblastoma in C57BL/6 mice Biomed Pharmacother 2019 113:108734
Liu Y, Di S, Shi B, Zhang H, Wang Y, Wu X, Luo H, Wang H, Li Z*, Jiang H* （通讯作者） Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3-Targeted Chimeric Antigen Receptor-Engineered T Cells in Hepatocellular Carcinoma J Immunol 2019 203 (1):198-207
Wen Xu, Fei Song, Biao Wang, Kesang Li, Mi Tian, Min Yua, Xiaorong Pan, Bizhi Shi, Jianwen Liu, Jianren Gu, Zonghai Li, Hua Jiang* （通讯作者） The Effect of and Mechanism Underlying Autophagy in Hepatocellular Carcinoma Induced by CH12, a Monoclonal Antibody Directed Against Epidermal Growth Factor Receptor Variant III Cell Physiol Biochem 2018 46: 226-237
Hua Jiang, Huiping Gao, Juan Kong, Bo Song, Peng Wang, Bizhi Shi, Huamao Wang and Zonghai Li* Selective targeting of glioblastoma with EGFRvIII/EGFR bi-targeted chimeric antigen receptor T cell Cancer Immunol Res 2018 6(11):1314-1326
Yanyu Bi# Hua Jiang#, Peng Wang （共同第一作者）, Bo Song, Huamao Wang, Xianming Kong and Zonghai Li Treatment of hepatocellular carcinoma with a GPC3-targeted bispecific T cell engager Oncotarget 2017 8:52866-52876
Hua Jiang, Bo Song, Peng Wang, Bizhi Shi, Qixiang Li, Mingliang Fan, Shengmeng Di, Jie Yang, Zonghai Li* Efficient growth suppression in pancreatic cancer PDX model by fully human anti-mesothelin CAR-T cells Protein & Cell 2017 8(12): 926–931
Xiuqi Wu, Bizhi Shi, Jiqin Zhang, Zhimin Shi, Shengmeng Di, Minliang Fan, Huiping Gao, Hai Wang, Jianren Gu, Hua Jiang* （通讯作者）, Zonghai Li A fusion receptor as a safety switch, detection and purification biomarker for adoptive transferred T cells Mol Ther 2017 25(10): 2270-2279
Wen Xu, Yanyu Bi, Juan Kong, Jiqin Zhang, Biao Wang, Kesang Li, Mi Tian, Xiaorong Pan, Bizhi Shi, Jianren Gu, Hua Jiang* （通讯作者）, Xianming Kong*, Zonghai Li* Combination of CH12 with Rapamycin Synergistically Inhibits the Growth of GFRvIII+PTEN- Glioblastoma in Vivo Oncotarget 2016 7(17):24752-65
Hua Jiang#, Qiongna Dong#, Xiaoying Luo, Bizhi Shi, Huamao Wang, Huiping Gao, Juan Kong, Jiqin Zhang, Zonghai Li. The Monoclonal Antibody CH12 Augments 5-Fluorouracil-Induced Growth Suppression of Hepatocellular Carcinoma Xenografts Expressing Epidermal Growth Factor Receptor Variant III Cancer Letters 2014 342(1):113-120
Yaqiong Yang#, Hua Jiang# （共同第一作者）, Huiping Gao, Juan Kong, Pengwei Zhang, Suwen Hu, Bizhi Shi, Pengfei Zhang, Ming Yao and Zonghai Li* The Monoclonal Antibody CH12 Enhances the Sorafenib-Mediated Growth Inhibition of Hepatocellular Carcinoma Xenografts Expressing Epidermal Growth Factor Receptor Variant III Neoplasia 2012 14(6):509-518
Hua Jiang, Huamao Wang, Zhonghua Tan, Suwen Hu, Hai Wang, Bizhi Shi, Lin Yang, Peiyong Li, Jianren Gu, Hongyang Wang, and Zonghai Li* Growth Suppression of Human Hepatocellular Carcinoma Xenografts by a Monoclonal Antibody CH12 Directed to Epidermal Growth Factor Receptor Variant III J Biol Chem 2011 286(2):5913-5920
Xiao Yao# （共同第一作者）, Hua Jiang#, Cuizhen Zhang#, Huamao Wang, Lin Yang, Yongfeng Yu, Junming Yu, Bizhi Shi, Zhijun Shen, Huiping Gao, Zhiwei Chen, Shujun Tian, Shun Lu, Zonghai Li*, and Jianren Gu. Dickkopf-1 autoantibody is a novel serological biomarker for non-small cell lung cancer Biomarkers 2010 15(2):128-134
Huamao Wang#, Hua Jiang# （共同第一作者）, Min Zhou, Zhibing Xu, Shiguo Liu, Bizhi Shi, Xiao Yao, Ming Yao, JianRen Gu, Zonghai Li* Epidermal growth factor receptor vIII enhances tumorigenicity and resistance to 5-fluorouracil in human hepatocellular carcinoma Cancer Letters 2009 279():30-38
Hua Jiang, Xiu-mei Cai, Bi-zhi Shi, Jie Zhang, Zong-hai Li*, Jian-ren Gu* Development of efficient RNA interference system using EGF-displaying phagemid particles Acta Pharmacol Sin 2008 29(4):437-442
Hua Jiang, Jie Zhang, Bi-zhi Shi, Yu-hong Xu, Zonghai Li*, Jianren Gu* Application of EGFP-EGF fusions to explore the mechanism of endocytosis of epidermal growth factor Acta Pharmacol Sin 2007 28(1):111-117