导师姓名： 吴晔明 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属新华医院 三级学科/
专业领域： 普外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： wuymsh@163.com
邮编： 200092 邮箱地址： wuymsh@163.com

研究方向 (点击浏览详细信息)
儿童肿瘤的发病机制和耐药机制研究

社会任职
中华小儿外科分会委员、肛肠学组副组长
中国抗癌协会儿童抗癌分会副主任委员
上海医学会小儿外科分会主任委员
中国医师协会小儿外科分会常委
上海医学会理事

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 中药丹参酮类外用制剂治疗小儿血管瘤临床前研究 上海市科委 2018-04~2021-06 70万元 课题负责人
** 基于PDX模型的神经母细胞瘤临床耐药机制动态研究, 国家自然基金面上项目，?? 2016-01~2019-12 65万元 课题负责人
** HIF1α通过Hedgehog信号通路调节神经母细胞瘤生物学特性的机制研究 国家自然基金面上项目 2013-01~2016-12 75万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Kai Chen, Yuanxia Cai, Cheng Cheng, Junqi Zhang, Fan Lv, Guofeng Xu, Peiwen Duan, Yeming Wu & Zhixiang Wu （通讯作者） MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex Oncogene 2020 Published: 06 April 2020 https://doi.org/10.1038/s41388-020-1268-6
Chen K, Cai Y, Zhang M, Wu Z, Wu Y.. （通讯作者） Both serum and tissue Galectin-1 levels are associated with adverse clinical features in neuroblastoma. Pediatr Blood Cancer 2018 2018 May 24:e27229. doi: 10.1002/pbc.27229.
Gu Y, Ding X, Huang J, Xue M, Zhang J, Wang Q, Yu H, Wang Y, Zhao F, Wang H, Jin M, Wu Y （通讯作者）, Zhang Y. The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells. Cell Death Dis 2018 2018 May 1;9(5):459
Cai Y, Lv F, Kaldybayeva N, Zhamilya A, Wu Z, Wu Y. （通讯作者） 15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms?in Vitro?and?in Vivo. Front Pharmacol 2018 2018 Jan 30;9:25. doi: 10.3389/fphar.2018.00025
Gu S, Chen K, Yin M, Wu Z, Wu Y. （通讯作者） Proteomic profiling of isogenic primary and metastatic medulloblastoma cell lines reveals differential expression of key metastatic factors. J Proteomics. 2017 2017 Mar 28. pii: S1874-3919
Zhang M, Jiang Z, Chen S, Wu Z, Chen K, Wu Y. （通讯作者） Legumain correlates with neuroblastoma differentiation and can be used in prodrug design. Chem Biol Drug Des 2017 2017 Oct 10. doi: 10.1111/cbdd.13116. [Epub ahead of print]
Wang Y, Wu Y （通讯作者）, Wang L, Yuan X, Jiang M, Li Y. Analysis of Recurrent Sacrococcygeal Teratoma in Children: Clinical Features, Relapse Risks, and Anorectal Functional Sequelae. Med Sci Monit. 2017 2017 Jan 2;23:17-23
Yi Wang1,4, Kai Chen1, Yihong Cai1, Yuanxia Cai1, Xiaojun Yuan2, Lifeng Wang3, Zhixiang Wu1 （通讯作者）,4* and Yeming Wu1; Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma. Journal of Experimental & Clinical Cancer Research 2017 (2017) 36:111,DOI 10.1186/s13046-017-0581-61
Yuan XJ1, Wang HM2, Jiang H3, Tang MJ1, Li ZL4, Zou X5, Fang YJ6, Pan C7, Tou JF8, Zhang KR9, Liu X10, Li WS11, Li Y12, Lu J13 （通讯作者）, Wu YM14 Multidisciplinary effort in treating children with hepatoblastoma in China. Cancer Lett 2016 2016 May 28;375(1):39-46.
Wang Y, Xiao Y, Chen K, Chen S, Zhang M, Wu Z, Wu Y （通讯作者） Enhancer of zeste homolog 2 depletion arrests the proliferation of hepatoblastoma cells Mol Med Rep. 2016 2016 Mar;13(3):2724-8.
Chen S, Gu S, Wang Y, Yao Y, Wang G, Jin Y, Wu Y. （通讯作者） Exposure to pyrethroid pesticides and the risk of childhood brain tumors in East China. Environ Pollut. 2016 2016 Sep 1. pii: S0269-7491(16)30988-5. doi: 10.1016/j.envpol.2016.08.066. [Epub ahead of print]
Chen K, Lv F, Xu G, Zhang M, Wu Y （通讯作者）, Wu Z. Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma. Oncotarget 2016 2016 Oct 7. doi: 10.18632/oncotarget.12513
Hu JM1,Hu M,Wu YM （通讯作者）,Wang J,Yan ZL,Zhang C,Pan WH,Xia H Long-term outcome of laparoscopic Nissen-Rossetti fundoplication versus Thal fundoplication in children with esophageal hiatal hernia: a retrospective report from two children's medical centers in Shanghai. World J Pediatr 2015 doi:10.1007
Chen S, Zhang M, Xing L, Wang Y, Xiao Y, Wu Y （通讯作者） HIF-1α Contributes to Proliferation and Invasiveness of Neuroblastoma Cells via SHH Signaling PLoS One 2015 10(3):e**
Wu YM1 （通讯作者）,Wang CD1,Lv F1,Zhang C1,Yan ZL2015 May 29. The Surgical Management of H-Type Rectovestibular Fistula: A Novel Modification. Eur J Pediatr Surg. 2015 doi:10.1055