导师姓名： 张晓玲 专业代码： 100210
性别： 女 专业名称： 外科学
培养单位： 附属新华医院 三级学科/
专业领域： 骨外
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市杨浦区双辽路768号新华医院科研中心二期323室
邮编： 200092 邮箱地址： xlzhang@sibs.ac.cn

研究方向 (点击浏览详细信息)

干细胞及骨关节衰老退变机制
免疫微环境特征及骨关节退变防治新策略
基于干细胞的骨软骨再生修复


社会任职
上海市中西医结合骨质疏松委员会委员（2018-2023）
国际华人肌骨骼研究学会（International Chinese Musculoskeletal Research Society，ICMRS）理事（2012-2015），女委员会（Woman Committee）主席（2013-2015），中国委员会主席（2019-2021）
国际矫形与创伤外科学会（SICOT）常委（2014-2020）
中华医学会骨科分会基础学组委员（2014-2020）
中国中西医结合学会骨伤科分会委员（2019-2024）
中国医师协会骨科医师分会委员（2014-2020）
中国生物材料学会生物材料先进制造分会委员（2016-2020）
中国生理学会基质生物学专业委员会委员（2016-2020）
Journal of Orthopaedic Translation国际编委会委员（2013-2020）
Chinese Journal of Clinicians （International）编委
中国研究型医院学会运动医学专业委员会委员（2019-2024）
中国组织工程研究与临床康复杂志编委
Case Reports in Orthopedic Research（S.Karger AG（瑞士卡尔格）集团期刊，瑞士著名医学和科技出版集团）主编（2017-2022）
中华关节外科杂志通信编委
科技部国家科技专家
教育部学位评议专家
国家自然基金评审专家
中国博士后基金评审专家
中国老年学学会骨质疏松委员会委员（2019-2014）
上海市科技奖励评审专家
上海市科学技术专家
全国卫生产业企业管理协会精准医疗分会常务理事（2019-2024）
中国研究型医院学会骨科创新与转化专业委员会(COIT)委员/骨科基础研究学组常务委员（2017-2022）
上海市生物工程学会委员（2018-2023）
Molecular Therapy （Nature 系列杂志）, Scientific Report, Aging Cell, Current gene therapy, Osteoporosis international, Current drug targets, Plos One, Cytotherapy, Acta Pharmacologica Sinica, Cell Adhesion & Migration, Gene, Acta Biochimica et Biophysica Sinica, Inflammation research, Therapeutic Advances in Musculoskeletal Disease, Clinical and Experimental Immunology等多种国内外专业杂志审稿人

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2020YFC** 增龄相关主要器官健康状况的调控和临床干预策略 国家重点研发计划项目 2020-07~2023-06 2724万元 课题负责人
HYZHXM01021 空间微重力环境对成体干细胞的生物学效应及关键信号分子研究 空间站工程航天医学实验领域项目 2020-01~2023-12 40万元 课题负责人
201903D321097 空间微重力环境对成体干细胞的生物学效应及关键信号分子研究 山西省重点研发计划项目 2019-12~2021-11 10万元 课题负责人
19XD** 骨关节炎靶向药物研发 上海市科技人才计划项目 2019-05~2022-04 40万元 课题负责人
** 关节区域免疫微环境特征及影响衰老性骨关节炎退变的机制 国家自然科学基金重点项目 2019-01~2023-12 293万元 课题负责人
** IL-12及IL-23调控间充质干细胞介导的骨修复的作用及机制 国家自然科学基金面上项目 2018-01~2021-12 55万元 课题负责人
** PIP5K1β在骨重建中的作用机制及作为骨质疏松治疗靶点的研究 上海市科委国际科技合作项目 2016-07~2019-06 30万元 课题负责人
** 骨修复材料与机体免疫微环境的相互作用及调节机制 上海交通大学医学院高峰高原计划项目 2016-07~2019-06 100万元 课题负责人
** 软骨干细胞分化调控及复合温敏性原位成型水凝胶修复关节软骨 国家自然科学基金面上项目 2016-01~2019-12 60万元 课题负责人
** 靶向于TNF-α抑制转录因子SATB2成骨机制的骨质疏松药物筛选 上海市科委科技支撑项目 2014-07~2017-09 40万元 课题负责人
2013ZYJB0501 膝关节骨关节炎的干预控制研究 上海市卫生系统重要疾病联合攻关项目 2014-01~2016-12 250万元 子课题负责人
** 靶向阳离子纳米载体输送DNA及siRNA治疗骨质疏松的研究 上海市科委国际科技合作项目 2013-06~2015-06 50万元 课题负责人
2013SMC-A-6 MicroRNA-146 调控骨关节炎软骨退变机制及干预策略 上海交通大学晨星青年****奖励计划SMC-晨星优秀青年教师 A类 2013-01~2015-12 15万元 课题负责人
力学负荷下腰椎终板软骨钙化机制的研究及干预新策略 上海市科委医学重点项目 2012-10~2015-09 25万元 课题负责人
11QH** Wnt/β-catenin信号在软骨内骨化中的调控 上海市科委启明星跟踪计划项目 2011-04~2013-03 15万元 课题负责人
10SG22 骨髓间充质干细胞成骨分化的表观遗传学调控 上海市教委（教育发展基金会）曙光计划项目 2011-01~2012-12 15万元 课题负责人
XDA** 骨组织构建基础与临床应用 中国科学院战略性先导科技专项 2011-01~2015-12 500万元 子课题负责人
KSCX2-EW-Q-1-07 C/EBP-alpha在骨髓间充质干细胞成骨成脂分化中的表观遗传学调控 中国科学院知识创新工程重要方向项目 2011-01~2013-12 80万元 课题负责人
YG2010MS48 基于可降解聚精胺纳米基因输送系统的骨再生治疗研究 上海交通大学“医工交叉研究基金”项目 2010-06~2012-05 8万元 课题负责人
2010B065 破骨细胞骨吸收关键蛋白Ac45功能研究 上海市科委白玉兰项目 2010-06~2011-05 2万元 课题负责人
1013J3 间充质干细胞免疫调节、分化调控的机制及临床应用研究 中科院方向性项目 2010-01~2010-12 30万元 课题负责人
2010CB945600 组织干细胞的干性维持、分化控制和免疫调节研究 科技部重大研究计划（973） 2010-01~2014-08 2600万元 子课题负责人
** 聚合物纳米粒介导 SiRNA 关节基因转移的应用基础研究 国家自然基金国际合作 2009-07~2009-12 4万元 课题负责人
构筑叶酸靶向非病毒纳米基因输送体系治疗关节炎的研究 国家自然科学基金国际(地区)合作交流项目NSFC-CIHR（中加） 2009-01~2011-12 45万元 子课题负责人
** C/EBP-alpha在骨髓间充质干细胞成骨分化中的表观遗传学调控 国家自然基金面上项目 2009-01~2011-12 33万元 课题负责人
骨关节炎的临床分期标准和阶梯化治疗方案研究 上海市科学技术委员会重点科技支撑计划 2008-10~2011-09 25万元 子课题负责人
构筑新型靶向阳离子聚合物纳米基因输送体系治疗关节炎的研究 上海市科委国际合作项目 2008-09~2010-09 25万元 课题负责人
** 去铁胺对BMP2 诱导的骨髓间充质干细胞向成骨细胞分化的调控 国家自然科学基金青年项目 2008-01~2010-12 15万元 课题负责人
07QA14062 去铁胺对骨髓间充质干细胞向成骨细胞分化的调控 上海市启明星人才基金 2007-09~2009-09 13万元 课题负责人
04ZR14064 IL-1Ra和IL-10联合基因治疗在骨性关节炎中的作用及分子机制 上海市科委,自然基金 2004-11~2007-11 5万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhu H, Hu Y, Wang C, Zhang X* （通讯作者）, He D*. CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-α in TMJ osteoarthritis. Cell Death Dis. 2020 11(4):284
Zhao DY, Jiang WB, Wang Y, Wang CD, Zhang XL* （通讯作者）, Li QF*, Han D*. Three-Dimensional-Printed Poly-L-Lactic Acid Scaffolds with Different Pore Sizes Influence Periosteal Distraction Osteogenesis of a Rabbit Skull. Biomed Res Int. 2020 **
Xu J, Li J, Hu Y, Dai K, Gan Y, Zhao J, Huang M, Zhang X*. （通讯作者） IL-23, but not IL-12, plays a critical role in inflammation-mediated bone disorders. Theranostics. 2020 10(9): 3925-3938
Shan S#, Fang B#, Zhang Y#, Wang C, Zhou J, Niu C, Gao Y, Zhao D, He J, Wang J, Zhang X* （通讯作者）, Li Q*. Mechanical stretch promotes tumoricidal M1 polarization via the FAK/NF-κB signaling pathway. FASEB J. 2019 33(12):13254-13266
Zhao J, Huang M, Zhang X, Xu J, Hu G, Zhao X, Cui P, Zhang X*. （通讯作者） MiR-146a deletion protects from bone loss in OVX mice by suppressing RANKL/OPG and M-CSF in bone microenvironment. J Bone Miner Res. 2019 jbmr.3832
Tong W#, Zeng Y#, Chow DHK, Yeung W, Xu J, Deng Y, Chen S, Zhao H, Zhang X, Ho KK, Qin L*, Mak KK*. Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade. Ann Rheum Dis. 2019 78(4):551-561
Huang MJ#, Zhao JY#, Xu JJ, Li J, Zhuang YF, Zhang XL*. （通讯作者） lncRNA ADAMTS9-AS2 Controls Human Mesenchymal Stem Cell Chondrogenic Differentiation and Functions as a ceRNA. Mol Ther Nucleic Acids. 2019 18:533-545
Geng Y, Zhao X, Xu J, Zhang X, Hu G, Fu SC, Dai K, Chen X, Patrick YS, Zhang X*. （通讯作者） Overexpression of mechanical sensitive miR-337-3p alleviates ectopic ossification in rat tendinopathy model via targeting IRS1 and Nox4 of tendon derived stem cells. J Mol Cell Biol. 2019 pii: mjz030
Xu J, Liu J, Gan Y, Dai K, Zhao J, Huang M, Huang Y, Zhuang Y, Zhang X*. （通讯作者） High-dose TGF-β1 impairs mesenchymal stem cell-mediated bone regeneration via Bmp2 inhibition. J Bone Miner Res. 2019 jbmr.3871
Liu JL, Li J, Xu JJ, Xiao F, Cui PL, Qiao ZG, Chen XD, Tao WD, Zhang XL*. （通讯作者） MiR-144 Inhibits Tumor Growth and Metastasis in Osteosarcoma via Dual-suppressing RhoA/ROCK1 Signaling Pathway. Mol Pharmacol. 2019 95(4):451-461
Cui P, Zhao X, Liu J, Chen X, Gao Y, Tao K, Wang C*, Zhang X*. （通讯作者） miR-146a interacting with lncRNA EPB41L4A-AS1 and lncRNA SNHG7 inhibits proliferation of bone marrow-derived mesenchymal stem cells. J Cell Physiol. 2019 jcp.29217
Zhao X#, Cui P#, Hu G, Wang C, Jiang L, Zhao J, Xu J, Zhang X*. （通讯作者） PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation. J Mol Cell Biol. 2019 pii: mjz028
Li D#, Wang H#, Li Z, Wang C, Xiao F, Gao Y, Zhang X, Wang P, Peng J, Cai G, Zuo B, Shen Y, Qi J, Qian N, Deng L, Song W, Zhang X, Shen L*, Chen X*. The inhibition of RANKL expression in fibroblasts attenuate CoCr particles induced aseptic prosthesis loosening via the MyD88-independent TLR signaling pathway. Biochem Biophys Res Commun. 2018 503(2):1115-1122
Xiao F#, Wang C#, Wang C#, Gao Y, Zhang X* （通讯作者）, Chen X*. BMPER Enhances Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells. Cell Physiol Biochem. 2018 45(5):1927-1939
Cui Y, Zhao X, Mei L, Pei J, Wang S, Shao Y, Tao Y, Zhang X* （通讯作者）, Jiang L*. Osteon Myospalacem Baileyi attenuates osteoclast differentiation trough RANKL induced NFAT pathways. J Ethnopharmacol. 2018 213: 65-71
Xu Y#, Xu S#, Gao Z, Xiao L, Xiao F, Xu H*, Zhang X*. （通讯作者） Degree of endplate chondrocyte degeneration in different tension regions during mechanical stimulation. Mol Med Rep. 2018 17(3):4415-4421
Wang C#, Xiao F#, Gan Y, Yuan W, Zhai Z, Jin T, Chen X, Zhang X*. （通讯作者） Improving Bone Regeneration Using Chordin siRNA Delivered by pH-Responsive and Non-Toxic Polyspermine Imidazole-4,5-Imine. Cell Physiol Biochem. 2018 46(1):133-147
Chijian Zuo#, Xiaoying Zhao#, Yu Shi, Wen Wu, Ning Zhang, Jiake Xu, Chuandong Wang, Guoli Hu, and Xiaoling Zhang*. （通讯作者） TNF-α inhibits SATB2 expression and osteoblast differentiation through NK-kB and MAPK pathways. Oncotarget. 2018 9(4):4833-4850
Huang M, Zhao J, Huang Y, Dai L, Zhang X*. （通讯作者） Meta-analysis of urinary C-terminal telopeptide of type II collagen as a biomarker in osteoarthritis diagnosis. J Orthop Translat. 2018 13:50-57
Li D#, Wang C#, Li Z#, Wang H#, He J, Zhu J, Zhang Y, Shen C, Xiao F, Gao Y, Zhang X, Li Y, Wang P, Peng J, Cai G, Zuo B, Yang Y, Shen Y, Song W, Zhang X* （通讯作者）, Shen L*, Chen X*. Nano-sized Al2O3 particle-induced autophagy reduces osteolysis in aseptic loosening of total hip arthroplasty by negative feedback regulation of RANKL expression in fibroblasts. Cell Death Dis. 2018 9(8):840
Gao Y#, Xiao F#, Wang C, Wang C, Cui P, Zhang X* （通讯作者）, Chen X*. Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells. J Cell Biochem. 2018 119(8):6986-6996
Gao Y#, Xiao F#, Wang C, Wang C, Cui P, Zhang X* （通讯作者）, Chen X*. Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells. J Cell Biochem. 2018 119(8):6986-6996
Wang C#, Xiao F#, Qu X, Zhai Z, Hu G, Chen X#, Zhang X#. （通讯作者） Sitagliptin, An Anti-diabetic Drug, Suppresses Estrogen Deficiency-Induced OsteoporosisIn Vivo and Inhibits RANKL-Induced Osteoclast Formation and Bone Resorption In Vitro. Front Pharmacol. 2017 8:407
Wang C#, Yuan W#, Xiao F#, Gan Y, Zhao X, Zhai Z, Zhao X, Zhao C, Cui P, Jin T, Chen X, Zhang X*. （通讯作者） Biscarbamate Cross-Linked Low-Molecular-Weight Polyethylenimine for Delivering Anti-chordin siRNA into Human Mesenchymal Stem Cells for Improving Bone Regeneration. Front Pharmacol. 2017 8:572
Zhao X, Mei L, Pei J, Liu Z, Shao Y, Tao Y, Zhang X* （通讯作者）, Jiang L*. Sophoridine from Sophora Flower Attenuates Ovariectomy Induced Osteoporosis through the RANKL-ERK-NFAT Pathway. J Agric Food Chem. 2017 65(44):9647-9654
Hu G, Zhao X, Wang C, Geng Y, Zhao J, Xu J, Zuo B, Zhao C, Wang C, Zhang X*. （通讯作者） MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4. Cell Death Dis. 2017 8(10):e3140
Wang CL#, Wang H#, Xiao F#, Wang CD, Hu GL, Zhu JF, Shen C, Zuo B, Cui YM, Li D, Gao Y, Zhang XL* （通讯作者）, Chen XD*. Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip. Biochem Bioph Res Co. 2017 485(2):400-408
Wang C#, Shan S#, Wang C#, Wang J, Li J, Hu G, Dai K, Li Q#, Zhang X#. （通讯作者） Mechanical stimulation promote the osteogenic differentiation of bone marrow stromal cells through epigenetic regulation of Sonic Hedgehog. Exp Cell Res. 2017 352(2):346-356
Niu C#, Xiao F#, Yuan K, Hu X, Lin W, Ma R, Zhang X* （通讯作者）, Huang Z*. Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide- Induced Alveolar Bone Resorption. Front Pharmacol. 2017 8:626
Niu C, Yuan K, Ma R, Gao L, Jiang W, Hu X, Lin W, Zhang X* （通讯作者）, Huang Z*. Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway. Mol Med Rep. 2017 16(4):4879-4886
Zhang X#, Wang C#, Zhao J, Xu J, Geng Y, Dai L, Huang Y, Fu S, Dai K*, Zhang X*. （通讯作者） miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2. Cell Death Dis. 2017 8(4):e2734
Wang Y, Xu J, Zhang X, Wang C, Huang Y, Dai K*, Zhang X*. （通讯作者） TNF-α-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis. Cell Death Dis. 2017 8(3):e2715
Tao He#, Yan Huang#, Chen Zhang, Denghui Liu, Chao Cheng, Weidong Xu* and Xiaoling Zhang*. Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis. Oncotarget. 2017 8(57):96993-97008
Huang Y#, Wu C#, Zhang X, Chang J*, Dai K*. Regulation of immune response by bioactive ions released from silicate bioceramics for bone regeneration. Acta Biomater. 2017 pii: S1742-7061(17)30558-5
Jiang L#, Zhao X#, Pei J, Mei L, Cui Y, Wang S, Shao Y, Zhang X* （通讯作者）, Tao Y*. Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways. J Funct Foods. 2017 37:594-602
Xu HG*, Gao Z, Ma MM, Xu JJ, Xiao L, Wang H, Zhang T, Liu X, Xu YM, Zhang XL*. （通讯作者） P120-catenin mediates intermittent cyclic mechanical tension-induced inflammation in chondrocytes. J Cell Biochem. 2017 118(12):4508-4516
Huang Y#, Wang J#, Yang F, Shao Y, Zhang X* （通讯作者）, Dai K*. Modification and evaluation of micro-nano structured porous bacterial cellulose scaffold for bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2017 75:1034-1041
Wang CL#, Xiao F#, Wang CD, Zhu JF, Shen C, Zuo B, Wang H, Li D, Wang XY, Feng WJ, Li ZK, Hu GL, Zhang X* （通讯作者）, Chen XD*. Gremlin2 Suppression Increases the BMP-2-Induced Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells Via the BMP-2/Smad/Runx2 Signaling Pathway. J Cell Biochem. 2017 118(2):286-297
Wang CD#, Wang J#, Li J, Hu GL, Shan SZ, Li QF* Zhang XL*. KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis. Cell Death Dis. 2016 7(8):e2335
Xu HG*, Ma MM, Zheng Q, Shen X, Wang H, Zhang SF, Xu JJ, Wang CD, Zhang XL*. （通讯作者） P120-catenin protects endplate chondrocytes from intermittent cyclic mechanical tension induced degeneration by inhibiting the expression of RhoA/ROCK-1 signaling pathway. Spine. 2016 41(16):1261-71
Wang J#, Wang CD#, Zhang N, Tong WX, Zhang YF, Shan SZ, Zhang XL* （通讯作者）, Li QF*. Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1. Cell Death Dis. 2016 7:e2221
Xu HG*, Zheng Q, Song JX, Li J, Wang H, Liu P, Wang J, Wang CD, Zhang XL*. （通讯作者） Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical Wnt signaling pathway and E-cadherin/β-catenin complex cross-talk. Osteoarthritis Cartilage. 2016 24(1):158-68
Chen D#, Liu Y#, Yang H, Chen D, Zhang X* （通讯作者）, Fermandes JC, Chen Y*. Connexin 43 promotes ossification of the posterior longitudinal ligament through activation of the ERK1/2 and p38 MAPK pathways. Cell Tissue Res. 2016 363(3):765-73
Xu J, Wang Y, Li J, Zhang X, Geng Y, Huang Y, Dai K*, Zhang X*. （通讯作者） IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4+ T cells. Cell Death Differ. 2016 23(12):1941-1951
Tong W, Geng Y, Huang Y, Shi Y, Xiang S, Zhang N, Qin L, Shi Q, Chen Q, Dai K,Zhang X*. （通讯作者） In Vivo Identification and Induction of Articular Cartilage Stem cells by Inhibiting NF-κB Signaling in osteoarthritis. Stem cells. 2015 33(10):3125-37
Zhang Y#, Wang J#, Cheng X, Yi B, Zhang X* （通讯作者）, Li Q*. Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway. Eur J Histochem. 2015 59(2):2467
Zuo B#, Zhu JF#, Li J, Wang CD, Zhao XY, Cai GQ, Li Z, Peng J, Wang P, Shen C, Huang Y, Xu J, Zhang XL* （通讯作者）, Chen XD*. microRNA-103a functions as a mechno-sensitive microRNA to inhibit bone formation through targeting Runx2. J Bone Miner Res. 2014 30(2):330-45
Du Z, Xiang S, Zang Y, Zhou Y, Wang C, Tang H, Jin T, Zhang X*. （通讯作者） Polyspermine imine, a pH Responsive Polycationic siRNA Carrier Degradable to Endogenous Metabolites. Mol Pharm. 2014 11(10):3300-3306
X HG*, Yu YF, Zheng Q, Zhang W, Wang CD, Zhao XY, Tong WX, Wang H, Liu P, Zhang XL*. （通讯作者） Autophagy protects end plate chondrocytes from intermittent cyclic mechanical tension induced calcification. Bone. 2014 66():232-239
Tong HJ, Liu HQ, Wang YY, Yang F, Shi Q, Fernandes JC, Dai KR, Zhang XL*. （通讯作者） A novel in vitro system for intracellular delivery of nonviral DNA. Journal of Orhtopaedic Translation. 2014 2():157-164
Wang J, Zhou J, Zhang N, Zhang X* （通讯作者）, Li Q*. A heterocyclic molecule kartogenin induces collagen synthesis of human dermal fibroblasts by activating the smad4/smad5 pathway. Biochem Biophys Res Commun. 2014 450(1):568-574
Huang X, Xu J, Huang M, Li J, Dai L, Dai K*, Zhang X*. （通讯作者） Histone deacetylase 1 promotes TGF-β1-mediated early chondrogenesis through down-regulating canonical Wnt signaling. Biochem Biophys Res Commun. 2014 453(4):810-816
Zhao X, Qu Z, Tickner J, Xu J*, Dai K, Zhang X*. （通讯作者） The Role of SATB2 in Skeletogenesis and Human Disease. Cytokine Growth Factor Rev. 2014 25(1):35-44
Zhang L, Yang C*, Li J, Zhu Y, Zhang X*. （通讯作者） High extracellular magnesium inhibits mineralized matrix deposition and modulates intracellular cacium signaling in human bone marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun. 2014 450(4):1390-1395
He T*, Wu W, Huang Y, Zhang X, Tang T, Dai K. Multiple biomarkers analysis for the early detection of prosthetic aseptic loosening of hip arthroplasty. Int Orthop. 2013 37(6):1025-1031
Li J, Zhang N, Huang X, Xu J, Fernandes JC, Dai K*, Zhang X*. （通讯作者） Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation. Cell Death Dis. 2013 4:e832
Tong H, Wang C, Huang Y, Shi Q, Fernandes JC, Dai K, Tang G*, Zhang X*. （通讯作者） Polyethylenimine600-β-cyclodextrin: a promising nanopolymer for nonviral gene delivery of primary mesenchymal stem cells. Int J Nanomedicine. 2013 8:1935-46
Tang Z, Xie Y*, Yang F, Huang Y, Wang C, Dai K, Zheng X, Zhang X*. （通讯作者） Porous Tantalum Coatings Prepared by Vacuum Plasma Spraying Enhance BMSCs Osteogenic differentiation and bone regeneration in vitro and in vivo. PLoS One. 2013 8(6):e66263
Fernandes JC, Qiu X, Winnik FM, Benderdour M, Zhang X, Dai K, Shi Q*. Linear polyethylenimine produced by partial acid hydrolysis of poly(2-ethyl-2-oxazoline) for DNA and siRNA delivery in vitro. Int J Nanomedicine. 2013 8():4091-4102
Lui PP, Lee YW, Wong YM, Zhang X, Dai K, Rolf CG*. Expression of Wnt pathway mediators in metaplasic tissue in animal model and clinical samples of tendinopathy. Rheumatology (Oxford) 2013 52(9):1609-1618
Xu HG*, Li ZR, Wang H, Liu P, Xiang SN, Wang CD, Zhang XL*. （通讯作者） Intermittent Cyclic Mechanical Tension-induced Down-regulation of Ectonucleotide Pyrophosphatase Phosphodiesterase 1 Gene Expression is Mainly Dependent on TGF-β1 in End-plate Chondrocytes. Orthop Surg. 2013 5(1):40-45
Xu HG*, Li ZR, Wang H, Liu P, Xiang SN, Wang CD, Zhang XL*. （通讯作者） Expression of ectonucleotide pyrophosphatase-1 in end-plate chondrocytes with transforming growth factor beta 1 siRNA interference by cyclic mechanical tension. Chin Med J (Engl) 2013 126(20): 3886-90
Cao L, Liu G, Gan Y, Fan Q, Yang F, Zhang X, Tang T, Dai K*. The use of autologous enriched bone marrow MSCs to enhance osteoporotic bone defect repair in long-term estrogen deficient goats. Biomaterials. 2012 33(20):5076-84
Zuo C, Huang Y, Bajis R, Sahih M, Li YP, Dai K, Zhang X*. （通讯作者） Osteoblastogenesis regulation signals in bone remodeling Osteoporos Int. 2012 23(6):1653-63
Xiang S#, Su J#, Tong H, Yang F, Tong W, Yuan W, Wu F, Wang C, Jin T*, Dai K, Zhang X*. （通讯作者） Biscarbamate cross-linked low molecular weight PEI for delivering IL-1 receptor antagonist gene to synoviocytes for arthritis therapy. Biomaterials. 2012 33(27):6520-32
Xu HG*, Zhang XH, Wang H, Liu P, Wang LT, Zuo CJ, Tong WX, Zhang XL*. （通讯作者） Intermittent Cyclic Mechanical Tension (ICMT) Induced Calcification and Down-regulation of ankh Gene Expression of End-plate Chondrocytes. Spine. 2012 37(14):1192-7
Shi Y#, Fu Y#, Tong W, Geng Y, Lui PP, Tang T, Zhang X* （通讯作者）, Dai K*. Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway. J Cell Biochem. 2012 113(10):3133-42
Wu Y, Zhang X, Zhang P, Fang B*, Jiang L. Intermittent Traction Stretch Promotes the Osteoblastic Differentiation of Bone Mesenchymal Stem Cells by the ERK1/2-Activated Cbfa1 Pathway. Connect Tissue Res. 2012 53(6):451-459
Xiang S, Tong H, Shi Q, Fernandes JC, Jin T, Dai K, Zhang X*. （通讯作者） Uptake mechanisms of non-viral gene delivery. J Control Release. 2012 158(3):371-8
Huang Y, Zhang X, Du K, Yang F, Shi Y, Huang J, Tang T, Chen D, Dai K*. Inhibition of β-catenin signaling in chondrocytes induces delayed fracture healing in mice. J Orthop Res. 2012 30(2):304-10
Li J, Huang J, Dai L, Yu D, Chen Q, Zhang X* （通讯作者）, Dai K*. MiR-146a, an interleukin-1beta responsive microRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4. Arthritis Res Ther. 2012 14(2):R75
Fernandes JC, Qiu X, Winnik FM, Benderdour M, Zhang X, Dai K, Shi Q*. Low molecular weight chitosan conjugated with folate for siRNA delivery in vitro: optimization studies. Int J Nanomedicine. 2012 7():5833-5845
Li X, Zhang X, Shen G, Tang G*. Effects of tensile forces on serum deprivation-induced osteoblast apoptosis: expression analysis of caspases, Bcl-2, and Bax. Chin Med J (Engl). 2012 125(14):2568-2573
Jreyssaty C, Shi Q*, Wang H, Qiu X, Winnik FM, Zhang X, Dai K, Benderdour M, Fernandes JC. Efficient Nonviral Gene Therapy Using Folate-Targeted Chitosan-DNA Nanoparticles In Vitro. ISRN Pharm. 2012 2012:369270
Shi Y, Li H, Zhang X, Fu Y, Huang Y, Lui PP, Tang T, Dai K*. Continuous cyclic mechanical tension inhibited Runx2 expression in mesenchymal stem cells through RhoA-ERK1/2 pathway. J Cell Physiol. 2011 226(8):2159-69
Lin Z#, Solomon KL#, Zhang X# （共同第一作者）, Pavlos NJ, Abel T, Willers C, Dai K, Xu J, Zheng Q*, Zheng M*. In vitro evaluation of natural marine sponge collagen as a scaffold for bone tissue engineering. Int J Biol Sci. 2011 7(7):968-77
Shi Q*, Wang H, Tran C, Qiu X, Winnik FM, Zhang X, Dai K, Benderdour M, Fernandes JC. Hydrodynamic delivery of chitosan-folate-DNA nanoparticles in rats with adjuvant-induced arthritis. J Biomed Biotechnol. 2011 2011:148763
Shi Q, Zhang XL, Dai KR, Benderdour M, Fernandes JC*. siRNA therapy for cancer and non-lethal diseases such as arthritis and osteoporosis. Expert Opin Biol Ther. 2011 11(1):5-16
Yang F, Xie Y, Li H, Tang T, Zhang X, Gan Y, Zheng X*, Dai K*. Human bone marrow-derived stromal cells cultured with a plasma sprayed CaO-ZrO2-SiO2 coating. J Biomed Mater Res B Appl Biomater. 2010 95(1):192-201
Yang C, Yuan G, Zhang J, Tang Z, Zhang X, Dai K*. Effects of magnesium alloys extracts on adult human bone marrow-derived stromal cell viability and osteogenic differentiation. Biomed Mater. 2010 5(4):045005
Zhang X, Tang T, Shi Q, Fernandes JC, Dai K*. The immunologic properties of undifferentiated and osteogenic differentiated mouse mesenchymal stem cells and its potential application in bone regeneration. Immunobiology. 2009 214(3):179-86
Huang Y#, Jin X#, Zhang X, Sun H, Tu J, Tang T, Chang J*, Dai K*. In vitro and in vivo evaluation of akermanite bioceramics for bone regeneration Biomaterials. 2009 30(28):5041-8
Zhu J, Zhang X, Wang C, Peng X, Zhang X*. Periprosthetic strain magnitude-dependent upregulation of type I collagen synthesis in human osteoblasts through an ERK1/2 pathway. Int Orthop. 2009 33(5):1455-60
Fan Q, Tang T, Zhang X, Dai K*. The role of CCAAT/enhancer binding protein (C/EBP) alpha in osteogenesis of C3H10T1/2 cells induced by BMP-2. J Cell Mol Med . 2009 13(8B):2489-505
Tong H, Qin S, Fernandes JC, Li L, Dai K, Zhang X*. （通讯作者） Progress and prospects of chitosan and its derivatives as non-viral gene vectors in gene therapy. Curr Gene Ther. 2009 9(6):495-502
Hou H, Zhang X, Tang T, Dai K*, Ge R. Enhancement of bone formation by genetically-engineered bone marrow stromal cells expressing BMP-2, VEGF and angiopoietin-1. Biotechnol Lett. 2009 31(8):1183-9
Sun H, Dai K*, Tang T, Zhang X. Regulation of osteoblast differentiation by slit2 in osteoblastic cells. Cells Tissues Organs. 2009 190(2):69-80
Tu J#, Wang H#, Li H, Dai K, Wang J*, Zhang X*. （通讯作者） The in vivo bone formation by mesenchymal stem cells in zein scaffolds. Biomaterials 2009 30(26):4369-76
Zhang P, Han D, Tang T, Zhang X, Dai K*. The destruction evaluation in different foot joints: new ideas in collagen-induced arthritis rat model. Rheumatol Int. 2009 29(6):607-13
Han D, Sun X, Zhang X, Tang T, Dai K*. Ectopic osteogenesis by ex vivo gene therapy using beta tricalcium phosphate as a carrier. Connect Tissue Res. 2008 49(5):343-50
Zhang P, Han D, Tang T, Zhang X, Dai K*. Inhibition of the Development of Collagen-Induced Arthritis in Wistar Rats through Vagus Nerve Suspension: A 3-month Observation. Inflamm Res. 2008 57(7):322-8
Zhang C, Tang T, Ren W, Zhang X, Dai K*. Influence of mouse genetic background on wear particle-induced in vivo inflammatory osteolysis. Inflamm Res. 2008 57(5):211-5
Dai KR, Zhang XL, Shi Q, Fernandes JC*. Gene therapy of arthritis and orthopaedic disorders: current experimental approaches in China and in Canada. Expert Opin Biol Ther. 2008 8(9):1337-46
Fernandes JC, Wang H, Jreyssaty C, Benderdour M, Lavigne P, Qiu X, Winnik FM, Zhang X, Dai K, Shi Q*. Bone-protective effects of nonviral gene therapy with folate-chitosan DNA nanoparticle containing interleukin-1 receptor antagonist gene in rats with adjuvant-induced arthritis. Mol Ther. 2008 2008 Jul;16(7):1243-51
Qu ZH, Zhang XL, Tang TT, Dai KR*. Promotion of osteogenesis through beta-catenin signaling by desferrioxamine. Biochem Biophys Res Commun. 2008 370(2):332-7
Qu ZH, Wang HJ, Tang TT, Zhang XL, Wang JY, Dai KR*. Evaluation of the zein/inorganics composite on biocompatibility and osteoblastic differentiation. Acta Biomater. 2008 4(5):1360-8
Zhang X, Zhang C, Tang T, Qu Z, Lou J, Dai K*. Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and J Orthop Res. 2008 26(3):314-21
Sun X, Gan Y, Tang T, Zhang X, Dai K*. In vitro proliferation and differentiation of human mesenchymal stem cells cultured in autologous plasma derived from bone marrow. Tissue Eng Part A. 2008 14(3):391-400
Li H, Dai K*, Tang T, Zhang X, Yan M, Lou J. Bone regeneration by implantation of adipose-derived stromal cells expressing BMP-2. Biochem Biophys Res Commun. 2007 356(4):836-42
Zhang C, Tang TT, Ren WP, Zhang XL, Dai KR*. Inhibiting wear particles-induced osteolysis with doxycycline. Acta Pharmacol Sin. 2007 28(10):1603-10
Zhang X* （通讯作者）, Yu C, Xushi, Zhang C, Tang T, Dai K. Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo. Biochem Biophys Res Commun. 2006 341(1):202-8
Dai KR*, Xu XL, Tang TT, Zhu ZA, Yu CF, Lou JR, Zhang XL. Repairing of goat tibial bone defects with BMP-2 gene-modified tissue-engineered bone. Calcif Tissue Int. 2005 77(1):55-61
Yue, B, Lu, B, Dai, KR, Zhang, XL, Yu, CF, Lou, JR, Tang, TT*. BMP2 gene therapy on the repair of bone defects of aged rats. Calcif Tissue Int. 2005 77(6): 395-403
Zhang X, Mao Z, Yu C*. Suppression of early experimental osteoarthritis by gene transfer of interleukin 1 receptor antagonist and interleukin 10. Journal of Orthopaedic Research. 2004 22(4):742-750