导师姓名： 刘辰莹 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属新华医院 三级学科/
专业领域： 普外
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： liuchenying@xinhuamed.com.cn

研究方向 (点击浏览详细信息)
结直肠癌相关的分子机制和新型靶向药物治疗
Hippo细胞信号通路的新分子调控机制及其在肿瘤里的生物学作用

社会任职
中国生物化学与分子生物学学会生物技术专业委员会青委会委员
国际肝胆胰协会中国分会转移性肝癌专业委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
无 上海市教委人才项目 上海市教委 2019-01~2021-12 60万元 课题负责人
** 转录因子TEAD4促进结直肠癌淋巴转移的生物学功能与机制研究 国自然面上项目 2019-01~2022-12 57万元 课题负责人
18PJ** 转录因子TEAD4在结直肠癌发生中的作用与机制研究 上海市浦江人才计划（A类） 2018-07~2020-06 20万元 课题负责人
** 转录因子TEAD4在结直肠癌发生中的作用与机制研究 上海交通大学医学院"高峰高原"项目 2017-07~2020-06 100万元 课题负责人
** 前列腺癌中转录共激活子TAZ的基因转录调控机制及其功能研究 国自然面上项目 2017-01~2020-12 57万元 课题负责人
YG2014MS71 利用果蝇模型筛选先天性巨结肠相关基因及功能研究 上海交通大学医工交叉面上项目 2015-01~2017-12 15万元 课题负责人
ZZjdyx13074 结直肠癌发病中Hippo抑癌信号通路的失活机制及靶向治疗研究 上海高校优秀青年教师培养资助计划 2014-01~2015-12 5万元 课题负责人
** TEAD4高表达：一种结直肠癌Hippo抑癌信号通路失活的新分子机制研究 国自然青年项目 2014-01~2016-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chao Wang,Xingyou Wan,Tong Yu,Zhenyu Huang,Chao Shen,Qian Qi,Sheng Xiang,Xinyuan Chen,Eyal Arbely,Zhi-Qiang Ling,Chen-Ying Liu （通讯作者）,Wei Yu Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis Cell Reports 2020 32(6):108021
Song J, Chen W, Cui X, Huang Z, Wen D, Yang Y, Yu W, Cui L, Liu CY. （通讯作者） CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer Theranostics 2020 10(5):2327-2341.
Zhehui Zhu, Jinglue Song, Yuegui Guo, Zhenyu Huang, Xiaojian Chen, Xuening Dang, Yuji Huang, Yuhan Wang, Weijun Ou, Yili Yang, Wei Yu, Chen-Ying Liu （通讯作者）, Long Cui LAMB3 promotes tumour progression through the AKT–FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer Oncogene 2020 online
Jialin Shang, Zhehui Zhu, Yingyi Chen, Jinglue Song, Yuji Huang, Kun Song, Jie Zhong, Xinyuan Xu, Jiacheng Wei, Chengxiang Wang, Long Cui, Chen-Ying Liu （通讯作者）, and Jian Zhang Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D3 in colorectal cancer Theranostics 2020 10(13):5845-5864.
Song J, Shen X, Huang Z, Liu Y, Cui L, Cui X, Liu CY. （通讯作者） Clostridium difficile toxin A and toxin B inhibit YAP in the colonic epithelial cells J Biochem Mol Toxicol. 2020 Nov 30:e22652.
Dongpeng Wen, Yuhan Wang, Zhehui Zhu, Zhenyu Huang, Long Cui, Tingyu Wu, Chen-Ying Liu （通讯作者） Bromodomain and Extraterminal (BET) protein inhibition suppresses tumor progression and inhibits HGF-MET signaling through targeting cancer-associated fibroblasts in colorectal cancer Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2020 In Press
Wei Z, Song J, Wang G, Cui X, Zheng J, Tang Y, Chen X, Li J, Cui L, Liu CY （通讯作者）, Yu W. Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis. Nat Commun. 2018 9(1):4468.
Zhu Z, Mei Z, Guo Y, Wang G, Wu T, Cui X, Huang Z, Zhu Y, Wen D, Song J, He H, Xu W, Cui L, Liu C. （通讯作者） Reduced Risk of Inflammatory Bowel Disease-associated Colorectal Neoplasia with Use of Thiopurines: a Systematic Review and Meta-analysis. J Crohns Colitis. 2018 12(5):546-558.
Wu T, Wang G, Chen W, Zhu Z, Liu Y, Huang Z, Huang Y, Du P, Yang Y, Liu CY （通讯作者）, Cui L. Co-inhibition of BET proteins and NF-κB as a potential therapy for colorectal cancer through synergistic inhibiting MYC and FOXM1 expressions. Cell Death Dis. 2018 9(3):315
Liu CY （通讯作者）, Pobbati AV, Huang Z, Cui L, Hong W Transglutaminase 2 Is a Direct Target Gene of YAP/TAZ-Letter. Cancer Research ( IF: 9.122 ) 2017 77(17):4734-4735.
Liu CY （通讯作者）, Yu T, Huang Y, Cui L, Hong W. ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer. J Biol Chem. ( IF: 4.125 ) 2017 292(22):9420-9430.
Liu CY, Chan SW, Guo F, Toloczko A, Cui L, Hong W. MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells. Oncotarget ( IF: 5.166 ) 2016 7(12):13706-16.
Huang Y, Wang G, Liang Z, Yang Y, Cui L, Liu CY. （通讯作者） Loss of nuclear localization of TET2 in colorectal cancer. Clinical Epigenetics ( IF: 4.987 ) 2016 8:9.
Liu Y, Wang G, Yang Y, Mei Z, Liang Z, Cui A, Wu T, Liu CY （通讯作者）, Cui L. Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner. Oncogene ( IF: 7.519 ) 2016 35(21):2789-800.
Lv XB, Liu CY, Wang Z, Sun YP, Xiong Y, Lei QY, Guan KL. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Reports ( IF: 8.568 ) 2015 16(8):975-85.
Wu T, Wang Z, Liu Y, Mei Z, Wang G, Liang Z, Cui A, Hu X, Cui L, Yang Y, Liu CY. （通讯作者） Interleukin 22 protects colorectal cancer cells from chemotherapy by activating the STAT3 pathway and inducing autocrine expression of interleukin 8. Clinical Immunology ( IF: 4.034 ) 2014 154(2):116-26.
Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q, Guan KL. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes & Development ( IF: 9.413 ) 2011 25(1):51-63.
Liu CY, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY, Guan KL. PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem. ( IF: 4.125 ) 2011 286(7):5558-66.
Liu CY, Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, Li T, Chan SW, Lim CJ, Hong W, Zhao S, Xiong Y, Lei QY, Guan KL. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem. ( IF: 4.125 ) 2010 285(48):37159-69.
Zhang H, Liu CY （共同第一作者）, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. ( IF: 4.125 ) 2009 284(20):13355-62.