导师姓名： 蒋雷生 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属新华医院 三级学科/
专业领域： 骨外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： **
邮编： 200092 邮箱地址： jiangleisheng@126.com

研究方向 (点击浏览详细信息)
脊柱外科，骨关节炎和骨质疏松

社会任职
上海康复医学会脊柱脊髓损伤专业委员会委员
中国医师协会骨科医师分会颈椎专业委员会委员
上海市中西医结合学会脊柱专业委员会胸腰椎组副组长
上海医学会骨科分会委员
上海市中西医结合学会骨伤学会副主任委员，中华创伤骨科杂志通讯编委，上海骨科学会脊柱学组副组长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 3.Lgr4对骨髓间充质干细胞成骨和成脂分化平衡的调控及其在骨质疏松发病机制中的作用 国家自然科学基金 2018-01~2021-12 55万元 课题负责人
** 自噬在机械应力诱导成骨细胞分化中的作用及机制研究 国家自然科学基金 2016-01~2019-12 68.4万元 课题负责人
11JC** 成骨细胞自噬在绝经后骨质疏松发病过程中的作用与机理研究 市科委 2012-01~2014-12 30万元 课题负责人
** TGF-β/Smad7信号通路在椎间盘退变病理过程中作用与机制研究 国家自然科学基金 2012-01~2015-12 58万元 课题负责人
U** 骨质疏松性椎体结构及功能异常的机制与脊柱退变的功能重建研究 国家自然科学基金 2011-01~2014-12 190万元 课题负责人
张力诱导椎间盘细胞凋亡的内质网应激机制 上海市“科技创新行动计划” 2009年度生物医药领域重点科技项目 2009-07~2012-06 25万元 课题负责人
08JC** 骨关节炎和骨质疏松的关系研究 上海市科委基础研究重点项目 2008-10~2010-09 35万元 课题负责人
05XJ21017 脊髓损伤对骨代谢影响的细胞分子机理研究 校基金 2005-10~2007-12 2万元 课题负责人
08JC** 骨关节炎和骨质疏松的关系研究 上海市科委，基础重点项目 ~2010-09 35万元

学术论文 作者论文标题期刊名出版年卷期页码
Xu WN, Yang RZ, Zheng HL, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS. （通讯作者） PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy. Int J Biol Macromol. 2019 136:1007-1017
Xu WN, Yang RZ, Zheng HL, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS （通讯作者） PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy Int J Biol Macromol 2019 136:1007-1017
Liu T, Li B, Zheng XF, Jiang SD, Zhou ZZ, Xu WN, Zheng HL, Wang CD, Zhang XL, Jiang LS. （通讯作者） Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway. Front Endocrinol (Lausanne） 2019 Jun 12;10:360
Ni B, Shen H, Wang W, Lu H, Jiang L （通讯作者） TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway. J Orthop Surg Res J Orthop Surg Res 2019 Jul 29;14(1):241
Zhou Z, Shi G, Zheng X, Jiang S, Jiang L （通讯作者） Autophagy activation facilitates mechanical stimulation-promoted osteoblast differentiation and ameliorates hindlimb unloading-induced bone loss Biochem Biophys Res Commun 2018 498(3):667-673.
Gui-Xun Shi, Xin-Feng Zheng Chao Zhu, Bo Li, Yu-Ren Wang, Sheng-Dan Jiang and Lei-Sheng Jiang Evidence of the Role of R-Spondin 1 and Its Receptor Lgr4 in the Transmission of Mechanical Stimuli to Biological Signals for Bone Formation Int J Mol Sci 2017 18(3). pii: E564
Zheng XF, Zhao ED, He JY, Zhang YH, Jiang SD, Jiang LS （通讯作者） Inhibition of substance P signaling aggravates the bone loss in ovariectomy-induced osteoporosis Prog Biophys Mol Biol 2016 122(2):112-121.
Zhu C, Zheng XF, Yang YH, Li B, Wang YR, Jiang SD, Jiang LS （通讯作者） LGR4 acts as a key receptor for R-spondin 2 to promote osteogenesis through Wnt signaling pathway. . Cellular Signalling 2016 28: 989–1000
Shi GX, Mao WW, Zheng XF, Jiang LS （通讯作者） The role of R-spondins and their receptors in bone metabolism Prog Biophys Mol Biol 2016 122(2):93-100.
Chen JW, Ni BB, Zheng XF, Li B, Jiang SD, Jiang LS. （通讯作者） Hypoxia facilitates the survival of nucleus pulposus cells in serum deprivation by down-regulating excessive autophagy through restricting ROS generation Int J Biochem Cell Biol 2015 59(2):1-10
Li B, Su YJ, Zheng XF, Yang YH, Jiang SD, Jiang LS （通讯作者） Evidence for an Important Role of Smad-7 in Intervertebral Disc Degeneration. J Interferon Cytokine Res 2015 35(7):569-579
Wang M, Zheng XF, Jiang LS （通讯作者） Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis PLoS One 2015 18;10(9)
Yang Y, Zheng X, Li B, Jiang S, Jiang L. （通讯作者） Increased activity of osteocyte autophagy in ovariectomized rats and its correlation with oxidative stress status and bone loss. Biochem Biophys Res Commun 2014 451(1):86-92
Yang YH, Li B, Zheng XF, Cheng JW, Chen K, Jiang SD, Jiang LS. （通讯作者） Oxidative damage to osteoblasts can be alleviated by early autophagy through the endoplasmic reticulum stress pathway-implications for the treatment of osteoporosis Free Radic Biol Med 2014 16(77):10-20
Cao P, Chen Z, Zheng Y, Wang Y, Jiang L （通讯作者）, Yang Y, Zhuang C, Liang Y, Zheng T, Gong Y, Zhang X, Wu W, Qiu S. Comparison of simple discectomy and instrumented posterior lumbar interbody fusion for treatment of lumbar disc herniation combined with Modic endplate changes Chin Med J (Engl) 2014 127(15):2789-2794
Zhang YH, LI HD, LI B, Jiang SD, Jiang LS. （通讯作者） Ginsenoside Rg3 induces DNA damage in human osteosarcoma cells and reduces MNNG-induced DNA damage and apoptosis in normal human cells Oncol Rep 2014 31: 919-925
Chen JW, Ni BB, Li B, Yang YH, Jiang SD, Jiang LS. （通讯作者） The Responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells: implications for disc gegeneration Cell Physiol Biochem 2014 34():1175-1189
Chen K, Yang YH, Jiang SD, Jiang LS. （通讯作者） Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population. Histochemistry and Cell Biology Histochem Cell Biol 2014 142(3):285-295
Chen JW, Li B, Yang YH, Jiang SD, Jiang LS. （通讯作者） Significance of hypoxia in the physiological function of intervertebral disc cells. Critical ReviewsTM in Eukaryotic Gene Expression 2014 24(3):193-204
Jiang SD, Chen JW, Yang YH, Chen XD, Jiang LS. （通讯作者） Intraobserver and interobserver reliability of measures of cervical sagittal rotation BMC Musculoskeletal Disorders 2014 15():332-
Ni BB, Li B, Yang YH, Chen JW, Chen K, Jiang SD, Jiang LS. （通讯作者） The effect of transforming growth factor β1 on the crosstalk between autophagy and apoptosis in the annulus fibrosus cells under serum deprivation Cytokine 2014 70(2):87-96
Li XF, Wang SJ, Jiang LS （通讯作者）, Dai LY. Stage specific effect of leptin on the expressions of estrogen receptor and extracellular matrix in a model of chondrocyte differentiation. Cytokine 2013 61: 876–884.
Zheng XF, Li B, Zhang YH, Yang YH, Meng XY, Jiang SD, Jiang LS. （通讯作者） Blockade of substance P receptor attenuates osteoporotic pain, but not bone loss, in ovariectomized mice. Menopause 2013 20:1074-1083.
Wu WJ, Zhang XK, Zheng XF, Yang YH, Jiang SD, Jiang LS. （通讯作者） SHH-dependent knockout of HIF-1 alpha accelerates the degenerative process in mouse intervertebral disc. Int J Immunopathol Pharmacol. 2013 26:601-9.
He JY, Zheng XF, Jiang SD, Chen XD, Jiang LS. （通讯作者） Sympathetic neuron can promote osteoblast differentiation through BMP signaling pathway. Cell Signal 2013 25: 1372–1378
Yang YH, Chen K, Li B, Chen JW, Zheng XF, Wang YR, Jiang SD, Jiang LS. （通讯作者） Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER-ERK-mTOR pathway. Apoptosis 2013 18:1363–1375
童天朗, 高悠水, 蒋雷生。 （通讯作者） 人骨髓间质干细胞成骨向脂肪转分化的研究。 同济大学学报( 医学版) 2013 34:34-39
Jiang SD, Yang YH, Chen JW, Jiang LS. （通讯作者） Isolated osteoblasts from spinal cord-injured rats respond less to mechanical loading as compared with those from hindlimbimmobilized rats. J Spinal Cord Med 2013 36: 220-224.
Li B, Jiang SD, Zheng XF, Ni BB, Yang YH, Chen JW, Chen K, Jiang LS. （通讯作者） Expression of the inflammatory molecule HMGB1 in human osteosarcoma and its clinical relevance. Euro J Inflamm 2013 11: 61-73
Zhang YH, Shen L, Shen Y, Chen XD, Jiang LS. （通讯作者） Study on Key Genes and Regulatory Networks Associated with Osteoporosis by Microarray Technology. Genet Test Mol Biomarkers. 2013 17:625-630.
Li B, Zheng XF, Ni BB, Yang YH, Jiang SD, Lu H, Jiang LS. （通讯作者） Reduced expression of insulin-like growth factor 1 receptor leads to accelerated intervertebral disc degeneration in mice. Int J Immunopathol Pharmacol 2013 26:337-347.
Wang SJ, Li XF, Jiang LS （通讯作者）, Dai LY. Estrogen stimulates leptin receptor expression in ATDC5 cells via the estrogen receptor and extracellular signal-regulated kinase pathways. J Endocrinol 2012 213(2):163-72.
Li B, Yang Y, Jiang S, Ni B, Chen K, Jiang L. （通讯作者） Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway Int J Oncol 2012 41(5):1809-19
Yan J, Li B, Chen JW, Jiang SD, Jiang LS. （通讯作者） Spinal cord injury causes bone loss through peroxisome proliferator-activated receptor-γ and Wnt signalling J Cell Mol Med 2012 16(12):2968-77
Jiang SD, Chen JW, Jiang LS. （通讯作者） Which procedure is better for lumbar interbody fusion: anterior lumbar interbody fusion or transforaminal lumbar interbody fusion? Arch Orthop Trauma Surg 2012 132(9):1259-66
Yang Y, Li H, Li B （通讯作者）, Wang Y, Jiang S, Jiang L. Efficacy and safety of iron supplementation for the elderly patients undergoing hip or knee surgery: a meta-analysis of randomized controlled trials. J Surg Res. 2011 171(2):e201-7
李海东,王宇仁,杨越华,王伟,蒋雷生 （通讯作者） 防治老年股骨转子间骨折隐性失血对术后功能恢复影响的随机对照研究；back pain with endplate Modic changes 中华创伤骨科杂志 2011 13（2）：125-129
Cao P, Jiang L （通讯作者）, Zhuang C, Yang Y, Zhang Z, Chen W, Zheng T Intradiscal injection therapy for degenerative chronic discogenic low back pain with endplate Modic changes Spine J 2011 11(2):100-106
Jiang LS, Shen L, Wang W, Wu H, Dai LY. Posterior atlantoaxial dislocation without fracture and neurologic deficit: a case report and the review of literature. Eur Spine J 2009 Aug 28. [Epub ahead of print]
沈雷,陆骅,蒋雷生 （通讯作者） 青少年胫骨远端三平面骨折的诊治。 中华创伤骨科杂志 2009 11：1035-1038
Jiang LS, Zhang ZM, Jiang SD, Chen WH, and Dai LY. Differential Bone Metabolism Between Postmenopausal Women With osteoarthritis and Osteoporosis. J Bone Miner Res 2008 23:475–483
Jiang LS, Shen L, Dai LY. Intramedullary fixation of subtrochanteric fractures with long proximal femoral nail or long gamma nail: technical notes and preliminary results. Ann Acad Med Singap 2007 36:821-826
Jiang LS, Cui YM, Zhou ZD, Dai LY. Stabilizing effect of the transferred conjoined tendon on shoulder stability. Knee Surg Sports Traumatol Arthrosc 2007 15:800–805