导师姓名： 李世亭 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属新华医院 三级学科/
专业领域： 神外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市杨浦区控江路1665号新华医院外科大楼（8号楼）16楼
邮编： 200092 邮箱地址： lsting66@163.com
研究方向 (点击浏览详细信息)
颅神经疾病外科，颅底神经外科
社会任职
上海交通大学医学院附属新华医院神经外科主任，上海交通大学颅神经疾病诊治中心主任，世界颅神经疾病外科医师联盟主席(WNFCND)，意大利罗马凯瑟琳大学客座教授，上海市神经外科专业委员会副主任委员,上海市功能神经外科专业学组组长，中华医学会神经外科分会全国委员，中华医学会神经外科分会功能神经外科学组副组长，中国医院管理学会神经微侵袭治疗专业委员会副主任委员,欧美同学会脑血管病分会副主任委员，中日神经外科医师联盟常委，中国医药教育协会神经外科专业委员会常委，中国抗衰老促进会神经系统疾病专业委员会常委，中国医疗保健国际交流促进会神经外科分会常委，中国医疗保健国际交流促进会神经损伤学分会常委，世界华人医师协会功能神经外科专业委员会常委,中国医师协会颅底神经外科专家委员会委员，中国医师协会功能神经外科专家委员会委员，并担任《The Journal of Chinese Neurosurgery》、《The Clinical Journal of Neurosurgery》《中华神经外科杂志》、《中华神经外科疾病研究杂志》、《中国微侵袭神经外科杂志》、《中国神经肿瘤杂志》等杂志的编委。牵头起草了三叉神经痛、面肌痉挛及显微血管减压术围手术期电生理监测三个中国专家共识。曾荣获上海市科技进步二等奖（两项）、卫生部科技进步三等奖、上海市临床医疗成果二等奖、上海市医学科技三等奖（两项）、上海市生命科学奖、上海市医学银蛇奖等。并被授予上海市医务工匠、上海市领军人才、上海市医学领军人才、上海市劳动模范、第八届中国医师奖、教育部新世纪优秀人才、上海市曙光****、上海市优秀学科带头人、上海市新****、上海市科技启明星、上海市医苑新星等。
科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 转录因子Foxc1调节CXCL12-CXCR4介导的自噬过程在促进雪旺氏细胞迁移及髓鞘修复中的作用与分子机制研究 国家自然基金委 2020-01~2023-12 55万元 课题负责人
XH2813 上海市领军人才 上海市 2020-01~2024-12 160万元 课题负责人
2019LJ20 上海市医学领军人才培养计划 上海市科委 2019-07~2022-06 45万元 课题负责人
18DZ** 石杉碱甲片对慢性缺血性脑血管疾病患者疔效的临床研究 上海市科委重点项目 2019-01~2021-12 200万元 课题负责人
18XD** 人脂肪干细胞在大鼠面神经损伤后修复中的作用与机制研究 上海市科委优秀学术带头人 2018-05~2021-04 40万元 课题负责人
** 缓释CXCL12对受损面神经雪旺氏细胞迁移及神经修复的影响与机制研究 国家自然基金委 2017-01~2020-12 57万元 课题负责人
YG2016ZD11 缓释CXCL12的纳米水凝胶在防止组织粘连和促进面神经功能修复中的作用与机制研究 上海交大医工交叉重点项目 2017-01~2019-12 75万元 课题负责人
16DZ** 颅神经疾病预防与诊治的科学理念普及与推广 上海市科委 2016-05~2017-04 30万元 课题负责人
14DZ** 右美沙芬治疗面部肌张力障碍的研究 上海市科委 2014-10~2016-12 100万元 课题负责人
2013SY019 微血管减压治疗三叉神经痛和面肌痉挛的技术进展与推广 上海市卫计委 2014-01~2016-12 50万元 课题负责人
XBR** 组织工程支架在三叉神经脱髓鞘后神经修复中的研究 上海市卫计委 2012-01~2014-12 100万元 课题负责人
** 组织工程化聚四氟乙烯在修复大鼠面神经损伤中的作用与机制研究 国家自然基金委,面上项目 2012-01~2015-12 55万元 课题负责人
11JC** 尼莫地平促进颅神经损伤修复的作用机制 上海市科委 2011-10~2014-12 45万元 课题负责人
同源神经干细胞的发育示踪及其在动眼神经损伤后功能修复中的作用与机制研究 上海市科委 2010-04~2012-12 45万元 课题负责人
SHDC** 慢性缺血性脑血管病规范化诊治技术的研究与推广 上海市卫生局 2008-01~2010-12 30万元 主要责任人
07SG21 提高MVD治疗三叉神经痛手术疗效的应用技术研究 上海市教委,曙光计划 2008-01~2010-12 15万元 课题负责人
微血管减压术治疗三叉神经痛的规范化诊治方案建立的研究 上海市科委,一般科技攻关 2007-10~2010-09 15万元 课题负责人
** 动眼神经损伤后神经再生及功能修复的研究 国家自然基金委,面上项目 2006-01~2008-12 26万元 课题负责人
05QMX1409 电生理学技术在动眼神经损伤和功能修复中的应用研究 上海市科委,启明星 2005-10~2008-12 15万元 课题负责人
学术论文 作者论文标题期刊名出版年卷期页码
MX Liu, J Zhong, L Xia, NN Dou, A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm. Neurological research. 2019 2019;41(4):335-340.
D Gao, T Tang, J Zhu, Y Tang, H Sun, CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2019 2019 Volume: 124 : 460-468
H Zhao, DZ Tang, J Zhu, X Zhang, YD Tang, Diffuse Large B Cell Lymphoma Presented as Trigeminal Neuralgia: 2 Cases Reported and Literature Review. WORLD NEUROSURGERY 2019 2019 Volume: 123 : 383-389
TTang, D Gao, X Yang, X Hua,, Exogenous Netrin-1 Inhibits Autophagy of Ischemic Brain Tissues and Hypoxic Neurons via PI3K/mTOR Pathway in Ischemic Stroke. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 2019 2019;28(5):1338-1345.
M Chen, M Yang, WP Zhou, Preliminary Study on the Relationship Between Inflammation and Hemifacial Spasm. World neurosurgery. 2019 2019 Volume: 125: E214-E220
X Zhang, XH Wang, H Zhao, YD Tang, P Zhou, Y Yuan, J Zhu, Surgical Treatment of Secondary Hemifacial Spasm: Long-Term Follow-Up. World neurosurgery. 2019 2019 Volume: 125 : E10-E15
B Tao, Y Ling, Y Zhang, S Li, P Zhou, X Wang, B Li, Z Jun, W Zhang, C Xu, J Shi, L Wang,, S Li*（李世亭）. CA10 and CA11 negatively regulate neuronal activity-dependent growth of gliomas. Mol Oncol 2019 2019;13(5): 1018-1032
X Zhang, X Kang, Q Jiang, H Zhao, Y Tang, J Zhu, P Zhou, Y Yuan, Efficacy of Biomedical Glue Sling Technique Versus Traditional Technique for Microvascular Decompression for Hemifacial Spasm with Refractory Hypertension. World neurosurgery. 2018 2018;110:e473-e478.
M Chen, SH Zheng, M Yang, ZH Chen, The diagnostic value of preoperative inflammatory markers in craniopharyngioma: a multicenter cohort study. Journal of neuro-oncology. 2018 2018;138(1):113-122.
BH Feng, XH Wang, Posterior Fossa Re-Exploration for Recurrent Trigeminal Neuralgia: Operative Findings and Surgical Techniques. The Journal of craniofacial surgery. 2018 2018;29(5):1284-1286.
, W Zhang, C Wu, H Gao, J Yu, X Wang, B Li, Z Jun, W Zhang, P Zhou, J Shi, L Wang, Y Gao, S Li*（李世亭） HOXC10 promotes proliferation and invasion and induces immunosuppressive gene expression in glioma. The FEBS journal. 2018 2018;285(12):2278-2291.
H Zhao, GF Li, X Zhang, YD Tang, P Zhou, J Zhu, Long-Term Efficacy of Initial Microvascular Decompression Versus Subsequent Microvascular Decompression for Idiopathic Hemifacial Spasm. World neurosurgery. 2018 2018;109:e778-e782.
14.H Zhao, J Zhu, X Zhang, YD Tang, P Zhou, XH Wang, Involved Small Arteries in Patients Who Underwent Microvascular Decompression for Hemifacial Spasm. World neurosurgery. 2018 2018;118:e646-e650.
Zhang X, Zhao H, Zhu J, Tang YD, Ying TT, Yuan Y, The effects of combined intraoperative monitoring of abnormal muscle response and Z-L response for hemifacial spasm. World Neurosurg 2017 Sep 4. pii: S1878-8750(17)31470-5
Zhao H, Zhang X, Zhu J, Tang YD, Bell's Palsy: Clinical Analysis of 372 Cases and Review of Related Literature. European Neurology 2017 2017 , 77 (3-4) :168-172
Zhao H, Zhang X,Tang YD, The Study of Calcium,Phosphonium, Magnesium, and Ferrum Concentration in Serum of Patients With Primary Trigeminal Neuralgia Journal of craniofacial surgery 2017 e235-e238
Zhao H,Li GF,Zhang X,Tang YD,Zhou P, Management of Primary Bilateral Trigeminal Neuralgia with Microvascular Decompression: 13-Case Series. World Neurosurg 2017 pii: S1878-8750
Zhao H, Zhang X, Zhu J, Tang YD, Operative complications of microvascular decompression for hemifacial spasm: lessons from experience of 1548 cases. World Neurosurg 2017 pii: S1878-8750(17)31325-6
Zhang X,Xu L, Zhao H,Tang YD,Zhu J, The Effect of Microvascular Decompression on Hemifacial Spasm With Atherosclerosis of Vertebral Artery" The Journal of Craniofacial Surgery 2017 28（6）：579-582
Zhang X, Zhao H, Zhu J, Tang YD, Ying TT, Yuan Y, The efficacy of biomedical glue sling technique in microvascular decompression for hemifacial spasm with refractory hypertension . World Neurosurg 2017 S1878-8750(17)31941-1
Zhao H,Li GF,Zhang X,Tang YD,Zhou P, Long-Term Efficacy of Initial Microvascular Decompression Versus Subsequent Microvascular Decompression for Idiopathic Hemifacial Spasm. World Neurosurg 2017 pii: S1878-8750.
H Zhao,J Zhu,YD Tang,X Zhang, Microvascular decompression for glossopharyngeal neuralgia: long-term follow up[J]. World neurosurgery 2017 102:151-156
Xin Zhang,Hua Zhao,Ting-Ting Ying,Yin-Da Tang,Jin Zhu, The effects of dual abnormal muscle response monitoring on microvascular decompression in patients with hemifacial spasm[J]. World Neurosurgery, Volume 101 2017 Pages 93-98
Tang,Y,Zheng,X,,T,Zhong,J,Li,S A successful treatment of hemifacial spasm coexisted with brainstem cavernoma[J]. Journal of Neurosurgical Sciences 2017 61(1),112-114
Zhao H, Zhang X, Tang YD, Nerve Combing for Trigeminal Neuralgia Without Vascular Compression Journal of craniofacial surgery 2017 28(1):e15-e16
Zhang X, Zhao H, Zhu J, Tang YD, Ying TT, Yuan Y, Long-term efficacy of nerve combing for the patients with trigeminal neuralgia who failed prior microvascular decompression. World Neurosurg 2017 Sep 21. pii: S1878-8750(17)31588-7
Wang CL,, Wang XQ, Li B, Zhong J,Zhou P, Tao BB Dual inhibition of PCDH9 expression by miR-215-5p upregulation in gliomas Oncotarget 2017 Feb 7;8(6):10287-10297
Zhang X, Zhao H, Zhu J, Tang YD, Ying TT, Yuan Y, Electromyographically Guided Nerve Combing Makes Microvascular Decompression More Successful in Hemifacial Spasm with Persistent Abnormal Muscle Response. World Neurosurg 2017 Jun;102:85-90.
Zhao H, Zhang X, Zhang Y, Tang YD, Zhu J, Wang XH, Ying TT, Results of Atypical Hemifacial Spasm with Microvascular Decompression: 14 Case Reports and Literature Review. World Neurosurg 2017 Sep;105:605-611.
Zhang X, Zhao H, Zhu J, Tang YD, Ying TT, Yuan Y, Outcome of Biomedical Glue Sling Technique in Microvascular Decompression for Hemifacial Spasm Involving the Vertebral Artery World Neurosurg 2017 104:186-191
Zhu J,Zhang X, Zhao H, Tang YD, Ying TT, Surgical Treatment of Hemifacial Spasm Caused by the Compression of Internal Auditory Canal of Facial Nerve The Journal of Craniofacial Surgery 2017 28(6):e564-e566
Wang XQ, Bai HM,, Sun H, Min LZ, Tao BB, Zhong J, Li B. Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cells. Oncotarget 2017 Jul 18;8(29):48027-48040.
Wei XY, Zheng XS, Treatment of Posterior Inferior Cerebellar Artery Adhesion on Petrous Bone During Microvascular Decompression Procedure for Hemifacial Spasm: Technique Note The Journal of Craniofacial Surgery 2017 28(6):e551-e554
Zhao H,Zhang X,Tang YD,Zhu J,Ying TT,Yan Y, Factors Promoting a Good Outcome in a Second Microvascular Decompression Operation When Hemifacial Spasm is Not Relieved After the Initial Operation[J]. World neurosurgery 2017 98: 872
Zhu J,Zhang X, Zhao H, Tang YD, Ying TT, Utility of Brainstem Trigeminal Evoked Potentials in Patients With Primary Trigeminal Neuralgia Treated by Microvascular Decompression The Journal of Craniofacial Surgery 2017 28(6):e571-e577
Zhang,X,Zhao,H,Tang,,Zhu,J, Wang,X, Li,S Comparison of the efficacy of reoperation, percutaneous radiofrequency thermocoagulation when microvascular decompression of trigeminal neuralgia is invalid[J]. Journal of Craniofacial Surgery. The Journal of craniofacial surgery 2016 27: e688-e690
Zhao,H,Zhang,X,Tang,,Zhu,J,Wang,X,Li,S Bell's palsy: clinical analysis of 372 cases and review of related literature[J]. European Neurology 2016 168,77(3-4)168-172
Bin Li,# Ming-Zhu Huang,# Xiao-Qiang Wang, Bang-Bao Tao, Jun Zhong, Xu-Hui Wang, Wen-Chuan Zhang, Papillary meningioma: an aggressive variant meningioma with clinical features and treatment: a retrospective study of 10 cases Int J Neurosci. 2015 Epub ahead of print
6.Feng B, Zheng X, Zhang W, Yang M, Tang Y, Zhong J, Hua X, Ying T, Management of vessels passing through the facial nerve in the treatment of hemifacial spasm Acta Neurochir (Wien) 2015 157(11): 1935-1940
Zhong J, Zhu J, Sun H, Dou NN, Wang YN, Xia TT, Liu MX, Delayed relief of hemifacial spasm after microvascular decompression: can it be avoided? Acta Neurochir (Wien) 2015 157(1): 93-98
Li Y, Zheng X, Hua X, Ying T, Zhong J, Zhang W, Neuroprotective effects of intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats on ischemic stroke Behav Brain Res 2015 Epub ahead of print
7.Feng B, Zheng X, Zhang W, Yang M, Tang Y, Zhong J, Hua X, Ying T, Microvascular Decompression for Trigeminal Neuralgia: Zone Exploration and Decompression Techniques J Craniofac Surg 2015 26(8):2381-4
Yin-da Tang, Xue-sheng Zheng, Ting-ting Ying, Yan Yuan, Nimodipine-mediated re-myelination after facial nerve crush injury in rats Journal of Clinical Neuroscience 2015 22 (2015) 1661–1668
Bin Li,# Ming-Zhu Huang,# Xiao-Qiang Wang, Bang-Bao Tao, Jun Zhong, Xu-Hui Wang, Wen-Chuan Zhang, PMC**TMEM140 is associated with the prognosis of glioma by promoting cell viability and invasion J Hematol Oncol 2015 8: 89. Published online 2015 Jul 22
Ying TT,, Zhong J, Li XY, Wang XH, Zhu J Clinical Usefulness of Somatosensory Evoked Potentials for Detection of Peripheral Nerve and Brachial Plexus Injury Secondary to Malpositioning in Microvascular Decompression J Clin Neurophysiol 2015 32(6):512-5
Huang X1, Qi Q2, Hua X3, Li X3, Zhang W3, Sun H3,, Wang X3, Li B3 Beclin 1, an autophagy-related gene, augments apoptosis in U87 glioblastoma cells Oncol Rep 2014 31(4):1761-7
Jin Zhu, Jun Zhong, Wei Jiao, Qiu-Meng Zhou, Hong-Xin Guan, Ning-Ning Dou, Yong-Nan Wang, Lei Xia, Via-Cerebellar-Fissures Approach for Microvascular Decompression of Trigeminal Nerve J Craniofac Surg 2014 25: 1438–1440
9.Zhong J, Zhu J, Sun H, Dou NN, Wang YN, Xia TT, Liu MX, Tao BB, Microvascular decompression surgery: surgical principles and technical nuances based on 4000 cases Neurol Res 2014 36(10):882-93
Wang XQ1, Huang MZ, Zhang H, Sun FB, Tao BB, Feng BH, Liao CL, Kochanski R, Hua XM, Clear cell meningioma: clinical features, CT, and MR imaging findings in 23 patients. J Comput Assist Tomogr 2014 38(2):200-8
Sun H1,, Zhong J, Zhang WC, Hua XM, Wan L, Zheng XS The strategy of microvascular decompression for hemifacial spasm: how to decide the endpoint of an MVD surgery Acta Neurochir (Wien) 2014 156(6):1155-9
Yang M1, Zheng X, Ying T, Zhu J, Zhang W, Yang X, Combined intraoperative monitoring of abnormal muscle response and Z-L response for hemifacial spasm with tandem compression type Acta Neurochir (Wien) 2014 156(6):1161-6
, Pan J, Hua XM, Liu H, Shen S, Liu JF, Li B, Tao BB, Ge XL, Wang XH, Shi JH, Wang XQ Endothelial nitric oxide synthase protects neurons against ischemic injury through regulation of brain-derived neurotrophic factor expression CNS Neurosci Ther 2014 20(2):154-64
Yi Li, Xuming Hua, Fang Hua, Wenwei Mao, Liang Wan, Are bone marrow regenerative cells ideal seed cells for the treatment of cerebral ischemia? Neural Regen Res 2013 8(13): 1201–1209
Wang XQ, Chen H, Zhao L,, Hu J, Mei GH, Jiang CC Intracranial papillary meningioma: a clinicopathologic study of 30 cases at a single institution. Neurosurgery 2013 73(5):777-90
Li X, Zheng X, Wang X, Li B, Ying T, Li Y, Microvascular decompression treatment for post-Bell's palsy hemifacial spasm Neurol Res 2013 35(2):187-192
Hong-Lin Ke ? Rong-Hu Ke ? Shi-Ting Li ?Bin Li ? Hai-Tao Lu ? Xiao-Qiang Wang Expression of RACGAP1 in high grade meningiomas:a potential role in cancer progression J Neurooncol 2013 113:327–332
, Tao BB, Gao Z, Li B, Wu Y, Feng BH, Wang XH, Wang XQ Clinical features and treatment of cavernous angiomas in the fourth ventricle :a series of six patients and review of the literature. J Neurological Sciences 2013 30(2):356-368
Li Y, Zheng X, Hua X, Ying T, Zhong J, Zhang W, Surgical treatment of hemifacial spasm with zone-4 offending vessel Acta Neurochir (Wien) 2013 155(5):849-853
Liang Q, Shi X, Wang Y, Song Y, Wang R, Microvascular decompression for hemifacial spasm: technical notes on pontomedullary sulcus decompression Acta Neurochir (Wien) 2012 154:1621-1626
Zhu J,, Zhong J, Guan HX, Ying TT, Yang M, Yang X, Zhou Q, Jiao W Role of arterioles in management of microvascular decompression in patients with hemifacial spasm J Clin Neurosci 2012 19(3):375-9
Zhong J,, Zhu J, Guan HX, Zhou QM, Jiao W, Ying TT, Yang XS, Zhang WC, Hua XM A Clinical Analysis on Microvascular Decompression Surgery in a Series of 3000 Cases Clin Neurol Neurosurg 2012 114(7):846-51
Zheng, X., B. Feng, W. Hong, W. Zhang, M. Yang, Y. Tang, J. Zhong,, S. Li Management of intraneural vessels during microvascular decompression surgery for trigeminal neuralgia World Neurosurg 2012 77(5-6):771-774
Zheng X, Hong W, Tang Y, Wu Z, Shang M, Zhang W, Zhong J, Sympathetic nerves bridge the cross-transmission in hemifacial spasm Neurosci Lett 2012 517(1):52-5
Zhu J,, Zhong J, Ying TT, Guan HX, Yang XS, Zhou QM, Jiao W Microvascular decompression for hemifacial spasm The Journal of craniofacial surgery 2012 23(5):1385-1387
Yang,, S. T. Li, J. Zhong, J. Zhu, Q. Du, Q. M. Zhou, W. Jiao, H. X. Guan Microvascular decompression on patients with trigeminal neuralgia caused by ectatic vertebrobasilar artery complex: technique notes Acta Neurochir (Wien) 2012 154(5):793-797
Zhou QM, Zhong J, Jiao W, Zhu J, Yang XS, Ying TT, Zheng XS, Dou NN, Wang YN, The role of autonomic nervous system in the pathophysiology of hemifacial spasm Neurol Res 2012 34(7):643-8
Zheng X, Hong W, Tang Y, Ying T, Wu Z, Shang M, Feng B, Zhang W, Hua X, Zhong J, Discovery of a new waveform for intraoperative monitoring of hemifacial spasms Acta Neurochir (Wien) 2012 154(5):799-805
微血管减压术治疗面肌痉挛的手术技术 中华神经外科疾病研究杂志 2011 10(2):185-186
Ying TT,, Zhong J, Li XY,Wang XH, Zhu J The value of abnormal muscle response monitoring during microvascular decompression surgery for hemifacial spasm Int J Surg 2011 9(4):347-351
Feng BH, Zheng XS, Zhang WC, Yang M, Tang YD, Zhong J, Hua XM, Ying TT, Surgical treatment of pediatric hemifacial spasm patients Acta Neurochir (Wien) 2011 153(5):1031-1035
Hong, W., X. Zheng, Z. Wu, X. Li, X. Wang, Y. Li, W. Zhang, J. Zhong, X. Hua, Clinical features and surgical treatment of trigeminal neuralgia caused solely by venous compression Acta Neurochir (Wien) 2011 153(5):1037-1042
Zhong J, Zhu J,, Guan HX Microvascular decompressions in patients with coexistent hemifacial spasm and trigeminal neuralgia Neurosurgery 2011 68(4):916-920
Zheng XS, Feng BH, Zhang WC, Hemifacial spasm caused by cross type vascular compression Neurol Res 2011 33(9):965-969
Zhong J,, Zhu J, Guan HX Is entire nerve root decompression necessary for hemifacial spasm? Int J Surg 2011 9(3):254-257
Zhong J, Zhu J,, Li XY, Wang XH, Yang M, Wan L, Guan HX An analysis of failed microvascular decompression in patients with hemifacial spasm: focused on the early reoperative findings Acta Neurochir (Wien) 2010 152(12):2119-2123
, Hong W, Tang Y, Ying T, Zhang W, Li X, Zhu J, Zhong J, Hua X, Xu S, Wan L, Wang X, Yang M, Li Y, Zheng X Re-operation for persistent hemifacial spasm after microvascular decompression with the aid of intraoperative monitoring of abnormal muscle response Acta Neurochir (Wien) 2010 152(12):2113-2118
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