摘要/Abstract

喹喔啉酮及其衍生物是一类重要的氮杂环化合物, 广泛存在于具有各种生物活性的天然产物、药物及功能材料中, 因此, 喹喔啉酮的C—H功能化引起了化学工作者的广泛关注. 电化学合成无需外加氧化还原试剂, 直接利用电子这一“清洁试剂”参与氧化还原反应, 具有反应条件温和及原子经济性好等特点, 十分符合绿色化学符合绿色化学和可持续发展的要求. 随着对电化学合成反应机理的深入研究以及反应设备的标准化, 该方法已经成为喹喔啉酮类化合物功能化的强有力工具. 综述了有机电化学在喹喔啉-2(1H)-酮C(3)—H功能化领域所取得的研究进展, 对反应的条件和机理进行了系统的总结, 并对该领域所面临的挑战及发展方向进行了展望与探讨.
关键词: 电化学, 喹喔啉-2(1H)-酮, C(3)—H功能化
Quinoxalinone and its derivatives are a class of important nitrogen heterocyclic compounds, which widely exist in natural products, drugs and functional materials. Therefore, the C—H functionalization of quinoxalinone has attracted extensive attention of chemical workers. In recent years, electrochemical synthesis directly uses electron as a “clean reagent” to participate in redox reaction without additional redox reagent, which has the characteristics of mild reaction conditions and good atom economy. This method meets the requirements of green chemistry and sustainable development. With the in-depth study on the mechanism of electrochemical synthesis and the standardization of reaction equipment, this method has become a powerful tool for functionalization of quinoxalineones. The recent advances in the electrochemical C(3)—H functionalization of quinoxaline-2(1H)-one are summarized. The reaction transformation conditions and mechanisms are systematically discussed, and the challenges and future directions of this field are included.
Key words: electrochemical synthesis, quinoxalin-2(1H)-one, C(3)—H functionalization


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