摘要/Abstract
通过电氧化醛和醇合成了一系列酯类化合物. 该电合成反应在室温下即可进行, 无需惰性气体保护、外源氧化剂、氮杂卡宾(NHC)催化剂和碱[如DBU (1,5-二氮杂二环[5.4.0]十一烯-5)等的参与. 反应采用简单易得的不分隔电解槽和恒电流模式, 具有反应条件温和、底物适用范围广、原料廉价易得和操作简便等优点, 为酯类化合物的绿色合成提供了一种新策略.
关键词: 有机电合成, 脱氢偶联, 酯化反应
A series of ester compounds were synthesized by direct oxidative coupling of aldehydes with alcohols. The electrosynthesis reaction can be carried out at room temperature without inert gas protection, external oxidants, N-heterocyclic carbene (NHC) catalyst and alkali (such as DBU (1,5-dizzabicyclo[5.4.0]undecen-5-ene)), etc. The oxidative esterification reaction processes in a simple and easily available undivided electrochemical cell and constant current mode. This protocol features mild reaction conditions, broad substrate scope, cheap and easily available starting materials, and simple operation, providing a new strategy for the green synthesis of ester compounds.
Key words: organic electrosynthesis, dehydrogenative coupling, esterification
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