摘要/Abstract

芳基碘化物的阳极氧化是一种绿色高效的用于合成高价碘试剂的方法，该方法用电流代替了化学试剂，避免了使用价格昂贵、反应后处理棘手的氧化剂，如m-CPBA，H₂O₂，Oxone，Selectfluor等.利用电化学合成的高价碘试剂，既可促进氟化、氧化环化等反应，也可成功地应用于天然产物的全合成.一价碘/三价碘氧化还原体系可用来高效地形成碳碳键、碳杂原子等化学键.此外，能回收循环再利用的芳基碘介质可用于间接阳极氟化，且容易和产物分离.总结近年来高价碘试剂的电化学合成方法及其介导的各种化学反应.
关键词: 电化学合成, 高价碘试剂, 氟化, 氧化环化
Anodic oxidation of aryl iodine compouds is a green and efficient method for the synthesis of hypervalent iodine reagents. This method replaces chemical reagents with electric current, avoiding the use of expensive and handle difficult oxidants such as m-CPBA, H₂O₂, oxone, selectfluor etc. Electrochemically generated hypervalent iodine reagents can not only promote fluorination, oxidative cyclization, but also be successfully applied in the total synthesis of natural products. In addition, recyclable aryl iodine mediator can be used to indirect anodic fluorination and easily separated from products. The organic electrochemical synthesis of hypervalent iodine reagents and their applications in various chemical transformations are reviewed.
Key words: electrochemical synthesis, hypervalent iodine reagent, fluorination, oxidative cyclization


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