摘要/Abstract

机械力化学近年来获得广泛关注. 利用机械力促进的C—H键官能化反应的报道也日趋增多, 正在成为一个新兴的研究热点. 与传统的溶剂中进行的有机反应相比, 机械力促进的有机反应通常反应时间较短且无需溶剂, 更符合绿色合成的要求. 值得注意的是, 基于机械化学出色的性能和潜力, 一些传统合成方法中长期存在的问题也能通过机械化学方法得以解决. 因此, 及时对该领域进行总结将有助于化学工作者全面了解其发展现状, 并促进发展更高效的机械化学合成方法. 综述了近几年来机械力促进的碳氢键官能化反应研究进展及合成应用, 并对该领域存在的局限性和发展前景进行分析和展望.
关键词: 机械化学, C—H键官能化, 球磨技术, 无溶剂, 绿色化学
Mechanochemistry has received increasing attention in the past decade. Among which, the mechanochemical C—H bond functionalization has emerged as a hot research topic. In comparison with the traditional solution-based organic reactions, the mechanochemical transformation features solvent-less conditions and short reaction time, constituting a green and efficient synthetic method in the modern chemical society. Notably, given the outstanding features, some long-standing challenges in the previous solution-based reactions could be well-solved by mechanochemical methods. Therefore, a timely comprehensive overview to recognize the present status of the mechanochemical C—H bond functionalization is of great importance to stimulate the development of more efficient synthetic methods. In this review, the state of the art for mechanochemical C—H bond transformation is presented. The limitation in this research field is also analyzed and the outlook of this area is prospected.
Key words: mechanochemistry, C—H bond functionalization, ball milling, solvent-free, green chemistry


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