摘要/Abstract

单氟烯烃结构单元广泛存在于药物及天然产物等复杂功能分子中, 同时也是重要的有机合成子, 在医药、生物和材料等领域具有广泛的应用. 因此, 开发绿色、经济且高效的合成单氟烯烃化合物的方法具有重要的科学意义和现实价值. 偕二氟烯烃C—F键官能化是制备单氟烯烃化合物的有效手段, 总结了在可见光氧化还原催化、可见光氧化还原/过渡金属协同催化条件下实现偕二氟烯烃C—F键官能化反应的研究进展, 主要介绍了底物适用范围、反应机理和合成应用, 并对它的发展前景进行了展望.
关键词: 可见光, 单氟烯烃, 偕二氟烯烃, C—F键官能化
Monofluoroalkene structural units widely exist in complex functional molecules such as drugs and natural products. They are also critical organic synthons with broad applications in medicine, biology, materials and other fields. Therefore, it is of great scientific significance and practical value to develop green, economical and efficient methods for synthesizing monofluoroalkenes. Functionalization of the C—F bond of gem-difluoroalkenes is an effective method to prepare monofluoroalkenes. The research progress in C—F bond functionalization of gem-difluoroalkenes under visible-light redox catalysis and visible-light redox/transition-metal synergistic catalysis, including the substrate scope, reaction mechanism, and synthesis applications, is summarized. Finally, the prospects of this reaction are also discussed.
Key words: visible-light, monofluoroalkene, gem-difluoroalkene, C—F bond functionalization


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