摘要/Abstract

有机硒杂环化合物由于其独特的生物活性, 在有机化学和药物合成中具有广泛应用. 众多关于有机硒杂环化合物的合成方法被相继报道, 但这些方法均存在一定不足. 报道了ICl催化下香豆素衍生物与二芳(烷)二硒醚在室温下的反应, 高效制备了一系列3-芳(烷)硒基香豆素衍生物. 该方法也适用于其他杂环化合物C_sp2—Se键构建. 与已有方法相比, 本方法具有反应条件温和, 底物适用范围广等优点, 为有机硒杂环化合物的制备提供了方法.
关键词: 碘鎓催化芳(烷)硒化, C_sp2—Se键构建, 杂环化合物, 二芳(烷)基二硒醚
Owing to their special biological activities, organic selenium heterocyclic compounds have widely applications in organic chemistry and drug synthesis. A series of methods for the synthesis of organoselenide heterocyclic compounds have been reported, however, shortcomings still exist. In this paper, an effective method for the synthesis of 3-aryl(alkyl)selenylcoumarin derivatives via the ICl-catalyzed selenation of coumarins with diaryl(alkyl)diselenide at room temperature is reported. In addition, this method is also suitable for the construction of C_sp2—Se bonds of other heterocyclic compounds. Compared to previous methods, this method has the advantages of mild conditions and wide functional groups tolerance, providing a general pathway to organoselenide heterocyclic compounds.
Key words: Iodine cation-catalyzed selenation, Construction of C_sp2—Se, Heterocyclic compounds, Diaryl(alkyl)diselenides


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