摘要/Abstract
发展了巴比妥衍生烯烃化合物与N-烷氧基丙烯酰胺之间的串联aza-Michael/分子内Michael加成反应. 该反应条件温和, 适用于克级制备, 为具有生物活性的螺巴比妥分子的高效合成提供了一种实用的方法.
关键词: 螺巴比妥, 哌啶酮, 串联反应, Michael加成
A highly efficient cascade aza-Michael/intramolecular-Michael reaction employing barbiturate-derived alkenes and N-alkoxy acrylamides has been developed. The reaction proceeds smoothly under mild conditions and is amenable to gram scale synthesis, providing a practical tool in the synthesis of bioactive spirobarbiturate piperidin-2-ones molecules in moderate to good yields.
Key words: spirobarbiturate, piperidin-2-one, cascade reaction, Michael addition
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