摘要/Abstract

在P(NMe₂)₃作用下, 含有α,β-不饱和酮结构单元的苯甲酰甲酸酯顺利发生分子内环丙烷化反应, 以中等至良好的收率生成环丙烷并[c]香豆素. 在优化的反应条件下, 该反应展示了较宽的底物适用范围和优秀的立体选择性, 从而为环丙烷并[c]香豆素的合成提供了简便高效的方法.
关键词: 苯甲酰甲酸酯, 环丙烷化反应, 环丙烷并[c]香豆素, 磷试剂
Under the treatment of P(NMe₂)₃, benzoylformates bearing an α,β-unsaturated ketone unit readily underwent an intramolecular cyclopropanation reaction, producing the corresponding cyclopropa[c]coumarins in moderate to good yields. Under the optimized conditions, the reaction exhibited a wide scope of substrates and excellent stereoselectivity, thus provides a facile and efficient method for the synthesis of cyclopropa[c]coumarins.
Key words: benzoylformates, cyclopropanation reaction, cyclopropa[c]coumarins, phosphorus reagent


PDF全文下载地址:

点我下载PDF