摘要/Abstract

多环稠合的芳香含氮杂环化合物是一类非常重要的含氮杂环化合物, 在药物和材料中得到了广泛的应用, 而吡啶并吲哚类化合物是其重要的一类. 目前, 这类化合物的合成方法并不是很多, 基于之前的工作基础, 发展了一个在三氟甲磺酸铁作为催化剂条件下, 利用邻氨基苯乙腈衍生物和3-二甲胺基烯胺酮类化合物作为反应原料, 在温和的反应条件下, 高效地选择性构建2-取代的吡啶并[2,3-b]吲哚结构的方法.
关键词: 吡啶并[2,3-b]吲哚, 铁盐, N, N-二甲基烯胺酮, 高选择性
Polycyclic aromatic nitrogen-containing heterocyclic compounds are an important class of nitrogen-containing heterocyclic compounds, which have been widely used in drugs and materials, and indole-fused pyridine compounds are one of them. At present, the methods for the synthesis of these compounds were less reported. Based on previous work, a new route to 2-substituted pyrido[2,3-b]indole derivatives was developed, which employed 2-(2-aminophenyl)acetonitrile derivatives and N,N-dimethyl enaminones as the reaction substrates. The reaction provided the desired product with high selectivity and efficiency.
Key words: pyrido[2,3-b]indole, iron salts, N, N-dimethyl enaminones, high selectivity


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