摘要/Abstract

芳基、烷基磷酸混酯是一类重要的有机磷化物, 广泛应用于生物、医药、农药、高分子以及材料科学等众多领域, 具有广阔的发展前景. 含磷基团所特有的物理、化学以及生物性质, 为其结构修饰、衍生化以及应用领域的拓展提供了更多可能, 因此, 该类化合物合成方法的研究具有重要的理论和现实意义. 综述了过去几十年芳基、烷基磷酸混酯化合物制备方法的研究进展, 列举了其应用实例, 分类总结了多种不同类型的含磷试剂向目标化合物转化的实验方法和发展历程, 选择性地探讨了反应的特点、机理以及在合成中的应用, 希望该综述能够为磷酸混酯类化合物新型制备方法的开发提供参考, 为相关领域的****、研究生以及其他人员提供一些有益借鉴.
关键词: 合成方法, 磷酸混酯, 有机磷化物
Aryl and alkyl mixed phosphates are very important phosphorus containing organic compounds, which are widely used in many fields, such as biology, medicine, pesticide, polymer, and material science. The unique physical, chemical, and biological properties of phosphorus-based motifs provide more possibilities for their structural modification, derivatization, and potential application. Therefore, the research on the preparation of these compounds has important theoretical and practical significance. In this paper, the research progress of the synthesis methodologies of aryl and alkyl mixed phosphate in the past few decades is reviewed. The application examples are listed. The experimental methods and development process of the conversion of various kinds of phosphorus containing reagents to target compounds are summarized. The characteristics, mechanism, and application of the reaction are discussed selectively as well. We hope that this review can provide a reference for the development of new preparation protocols of mixed phosphate, and provide some useful references for scholars, graduate students, and others in the related fields.
Key words: synthetic method, mixed phosphate, organic phosphorus compound


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