摘要/Abstract
金属氮宾的分子内碳氢键插入反应是合成氮杂环最有效的方法之一. 以2-叠氮基-N,N-二苄基乙酰胺为底物, 发展了无配体、无外加氧化剂条件下的铁催化分子内sp3-碳氢键胺化反应, 以中等到良好的收率合成了一系列咪唑啉酮类化合物.
关键词: 铁催化, 氮宾插入反应, 咪唑啉酮, 氮杂环合成
Transition-metal-nitrenoids intramolecular C—H insertion is one of the most effective methods to synthesize nitrogen-containing heterocycles. Using 2-azido-N,N-dibenzylacetamides as substrates, an iron-catalyzed intramolecular C(sp3)—H bond amination reaction under ligand-free and external oxidant-free conditions has been developed. A series of imidazolinones were synthesized in moderate to good yields.
Key words: iron catalysis, nitrene insertion, imidazolinone, synthesis of N-containing heterocycles
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