摘要/Abstract

2-氨基吡啶是一类重要的合成子, 具有独特的双亲核结构, 可与酮、醛、酸、多官能团酯类以及卤代芳烃等化合物反应, 以构建五元、六元含氮稠杂环. 近年来, 基于2-氨基吡啶的成环反应倍受关注. 鉴于此, 以底物种类为分类依据, 重点综述了近5年来基于2-氨基吡啶构建咪唑并[1,2-a]吡啶、吡啶并[1,2-a]嘧啶合成方法的研究进展, 总结了其在有机合成方法学、药物合成和荧光探针等领域的应用, 并展望了基于2-氨基吡啶的绿色化成环及其应用的未来发展趋势.
关键词: 2-氨基吡啶, 咪唑并[1,2-a]吡啶, 吡啶并[1,2-a]嘧啶, 氮稠环化合物, C—N键构建, 逆合成分析
2-Aminopyridine is a significant synthetic synthon, with unique dual nucleophilic structure. It can react with ketones, aldehydes, acids, multifunctional esters, halogenated aromatics and other compounds to synthesize five- and six-member azaheterocycles. In recent years, the cyclization reactions based on 2-aminopyridines have been under the spotlight. According to the different types of substrates, the research progress on the synthesis of imidazo[1,2-a]pyridines and pyrido[1,2-a]pyri- midines based on 2-aminopyridines in the past 5 years is reviewed, and its applications in organic synthesis methodology, drug synthesis and fluorescent probes are summarized. Furthermore, the development trend of green cyclization and its application based on 2-aminopyridines in the future are prospected.
Key words: 2-aminopyridine, imidazo[1,2-a]pyridine, pyrido[1,2-a]pyrimidine, azaheterocycle, C—N bond formation, retro- synthetic analysis


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