摘要/Abstract
报道了一种钯催化分子内Heck环化串联反应. 该反应使用3-取代保护的吲哚酰胺衍生物作为原料, 碘化钯作为催化剂, 4-(二甲氨基)三苯基膦作为配体, 在乙腈和甲苯混合溶剂中发生串联反应, 以优良的收率合成了氮杂桥环化合物. 该反应具有良好的官能团兼容性和较高的合成效率, 为“一锅法”构建稠环化合物提供了一种简便的方法.
关键词: 钯催化剂, 分子内Heck串联环化反应, 氮杂桥环化合物, 一锅法
Palladium-catalyzed intramolecular Heck tandem cyclization reactions were developed. With palladium iodide as a catalyst and 4-(dimethylamino)triphenylphosphine as a ligand, 3-substituted indoleamide derivatives were converted to bridged N-heterocyclic products in good yields under simple reaction conditions. The tandem reactions are featured by efficient construction of fused ring compounds in one pot and good functional group compatibility.
Key words: palladium catalyst, intramolecular Heck cyclization, bridged N-heterocyclic compound
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