摘要/Abstract
在酒石酸催化作用下, 以1,3-二噁烷-4,6-二酮、芳香醛、芳香胺和丙酮为原料, 通过四组分反应有效地合成了11种双螺环四氢喹啉双(1,3-二噁烷-4,6-二酮)衍生物. 该方法具有产物收率高、适用范围较广、反应温和、操作简单及环境友好等优点, 同时对反应机理进行了推测.
关键词: 酒石酸, 四组分反应, 1,3-二噁烷-4,6-二酮, 四氢喹啉双(1,3-二噁烷-4,6-二酮)衍生物
Eleven dispirotetrahydroquinoline-bis(1,3-dioxane-4,6-dione) derivatives were synthesized by a four-component reaction of 1,3-dioxane-4,6-dione, aromatic aldehydes, arylamines and acetone in the presence of tartaric acid. This method can provide the advantages of high yields, broader substrate scope, mild conditions, simple operation and environmental friendliness. Additionally, the reaction mechanism was also speculated.
Key words: tartaric acid, four-component reaction, 1,3-dioxane-4,6-dione, dispirotetrahydroquinoline-bis(1,3-dioxane-4,6- dione) derivative
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